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Irini Topalidou

@irinakitop.bsky.social
614 followers 792 following 74 posts

Researcher obsessed with little worms. Greek Senior staff scientist @HutchBasicSci @FredHutch

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Reposted by Irini Topalidou
Harmit Singh Malik @harmitmalik.bsky.social · 04/09/2026
Structure and sequence fill evolutionary gaps for essential centromeric proteins. Work by @jeremyahollis.bsky.social, @irinakitop.bsky.social, & Jason Stonick. Article by Kelsey Woodruff. www.fredhutch.org/content/www/... Paper: www.science.org/doi/10.1126/...
fredhutch.org
Structure and sequence fill evolutionary gaps for essential centromeric proteins
Researchers in the Basic Sciences Division track evolutionary origins for an essential protein
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Irini Topalidou @irinakitop.bsky.social · 17/08/2026
Friends and colleagues, I’d like to invite you to my seminar this Thursday, the 20th, as part of the GSA Seminar Series featuring the 2026 GSA Award recipients. I’d be very happy to see you there! 😊 ECT: 1:00–2:00 PM WCT: 10:00–11:00 AM
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Reposted by Irini Topalidou
Harmit Singh Malik @harmitmalik.bsky.social · 08/07/2026
The ever amazing Steve Henikoff! @fredhutch.org @basicsci.fredhutch.org
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Irini Topalidou @irinakitop.bsky.social · 01/07/2026
Many congrats to the amazing @jeremyahollis.bsky.social and the one-and-only @harmitmalik.bsky.social So much fun to be part of this collaboration!!! Worms, fish, and many other metazoan species come together to build this beautiful story!!! 🐛🐟🐀
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Robert Reich @rbreich.bsky.social · 29/06/2026
With heat waves shattering temperature records across the globe, leading to needless deaths, let me just say that history will not look fondly on those who put fossil fuel profits above saving the planet.
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Jason Shepherd @jasonsynaptic.bsky.social · 29/06/2026
Very excited for our new paper, now out in @cellcellpress.bsky.social! /🧵 The protein Tau forms intracellular toxic tangles in neurons in Alzheimer’s disease and Tauopathies. Tau pathology slowly spreads from cell-to-cell but the mechanisms are not clear /1 authors.elsevier.com/sd/article/S...
authors.elsevier.com
Arc mediates intercellular tau transmission via extracellular vesicles
Tau pathology spreads cell to cell, but the mechanisms of intercellular tau transmission remain unclear. We find that the neuronal gene Arc is critica…
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Irini Topalidou @irinakitop.bsky.social · 26/06/2026
It’s been a while since I mentioned how much I appreciate the worm community! Thank you all for replying to my message and for being so generous and eager to help! I appreciate you all!
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Reposted by Irini Topalidou
BWJones @bwjones.bsky.social · 24/06/2026
Progress in cancer research has been one of the incredible areas of biomedical advancement over the past two decades. Many cancers which were absolute death sentences just a few years ago are now chronic, managed conditions. And this was only possible through NIH/NCI/NIAID research/funding.
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Irini Topalidou @irinakitop.bsky.social · 24/06/2026
Hey C. elegans friends! What's your preferred method for cell-specific knockout or knockdown? Would love any paper recommendations too! Thank you!!!
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Irini Topalidou @irinakitop.bsky.social · 23/06/2026
Thank you, @fredhutch.org and @genetics-gsa.bsky.social for this great honor!
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Irini Topalidou @irinakitop.bsky.social · 19/06/2026
Special thanks to John Higgins for the article, Robert Hood for the photos, and the @fredhutch.org news team for bringing this piece together on the @genetics-gsa.bsky.social mentoring award. Special thanks to @singhvilabglia.bsky.social for the nomination. 💜 www.fredhutch.org/en/news/cent...
fredhutch.org
Fred Hutch senior staff scientist honored by Genetics Society of America
Dr. Irini Topalidou, a senior staff scientist at Fred Hutch Cancer Center, is the first winner of the Genetics Society of America Mentorship Award who isn’t a principal investigator or faculty member....
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Irini Topalidou @irinakitop.bsky.social · 09/06/2026
The GSA gave me the opportunity to write an article in GENETICS reflecting on my journey as an immigrant in the USA and how those experiences have shaped my life and career. Thank you to all of my mentees, friends, and family who have supported me along the way 🙏 academic.oup.com/genetics/adv...
academic.oup.com
A second life
Abstract. The Genetics Society of America Mentorship Award recognizes members of the scientific community for exceptional mentoring of geneticists at any c
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Irini Topalidou @irinakitop.bsky.social · 08/04/2026
Thank you GSA! 🙏🥹 @genetics-gsa.bsky.social
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Irini Topalidou @irinakitop.bsky.social · 10/03/2026
Truly honored to be part of this inspiring story, driven by the super talented student @jeremyahollis.bsky.social and made possible through the collaboration of four different labs at @basicsci.fredhutch.org. Science at its best!!!
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Harmit Singh Malik @harmitmalik.bsky.social · 03/03/2026
My awesome colleague, @yarimura.bsky.social, is recruiting a postdoc to start at the end of 2026 or early 2027! His lab uses cryo-EM to uncover structural basis of key chromatin events using native complexes isolated from human cells or Xenopus egg extracts! careers-fhcrc.icims.com/jobs/30706/p...
careers-fhcrc.icims.com
Fred Hutchinson Cancer Center
Fred Hutch is dedicated to the elimination of cancer and related diseases as causes of human suffering and death.
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Irini Topalidou @irinakitop.bsky.social · 25/02/2026
Big thanks to Aakanksha @singhvilabglia.bsky.social for the nomination, to J. Bai and @nlehrbach.bsky.social for supporting it, to A. Calixto, S. Karimzadegan, P. Gurung, J. Cattin-Ortola, M. Crawford, for their supportive letters and to all my mentees for making this job colorful and meaningful ♥️
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Irini Topalidou @irinakitop.bsky.social · 08/03/2025
Inspiring talks, signs, and crowd at today's #StandForScience2025 event in Seattle. Thanks to everyone who participated and gave us hope!
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Irini Topalidou @irinakitop.bsky.social · 03/03/2025
For this reason I was very pleased to see Tom Maniatis's article and petition on NIH’s decision to cap indirect cost reimbursement at 15% in @cellpress.bsky.social www.cell.com/cell/fulltex...
cell.com
Safeguarding the future of biomedical science in the United States
NIH’s abrupt decision to cap indirect cost reimbursement at 15% threatens the critical infrastructure supporting groundbreaking biomedical research in the United States. This policy jeopardizes Americ...
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Reposted by Irini Topalidou
Hate Liberals? Bite Me. @happyliberal.bsky.social · 01/03/2025
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Aaron Rupar @atrupar.com · 22/02/2025
that Trumpers think the US Postal *SERVICE* should be a profit-making enterprise exposes the fallacy in their conception of government
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Carl T. Bergstrom @carlbergstrom.com · 22/02/2025
Any talk you hear from the current administration about making the US more competitive in science and technology is utter bullshit. What they are doing is sabotaging our country for years if not decades to come.
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Ben Collins @bencollins.bsky.social · 17/02/2025
Maybe I wasn’t clear about this. I wanted more egg and no plane crash, not many plane crash and no egg.
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Senator Bernie Sanders @sanders.senate.gov · 16/02/2025
While Trump “floods the zone,” we must stay focused.  NO to oligarchy, tax breaks for the rich and cuts to working class programs. NO to authoritarianism and unlimited power for one man. YES to growing the union movement and raising wages. YES to health care as a human right.
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Katie Langin @klangin.bsky.social · 17/02/2025
Thanks to everyone who shared this request. We updated our new Trump Tracker blog today with the voices of some federal scientists who reached out. More to come. www.science.org/content/arti...
science.org
Trump Tracker: Firings, lawsuits and U.S. science in chaos
Follow President Donald Trump’s impact on U.S. research and science globally
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Reposted by Irini Topalidou
Katie Langin @klangin.bsky.social · 14/02/2025
Dear federal scientists: If you have been affected by the probationary firings and would be willing to speak with Science, please reach out to me by email (klangin@aaas.org) or on Signal. We can guarantee annonymity.
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Karen Attiah @karenattiah.bsky.social · 16/02/2025
I do think we will see a lot of people leaving America over this. Our country is going back to factory settings.
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Irini Topalidou @irinakitop.bsky.social · 17/02/2025
I foresee a massive brain drain of scientists from the U.S. in the next few years, along with immigrant scientists avoiding the country. Trump's voters destroyed the unique appeal the U.S. once had for scientists 😢😣
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STAT @statnews.com · 16/02/2025
Sweeping layoffs are set to hit federal health and science agencies, including at the NIH, and former director Monica Bertagnolli called the situation at the NIH “devastating.”
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Trump administration layoffs set to hit NIH are ‘devastating,’ former director Monica Bertagnolli says
Sweeping layoffs are set to hit federal health and science agencies, including at the NIH, and former director Monica Bertagnolli called the situation at the NIH “devastating.”
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Reposted by Irini Topalidou
Aaron Rupar @atrupar.com · 16/02/2025
It’s quite clear by now that the answer to “why is the Trump administration doing x terrible thing?” is that they are *trying* to dismantle America and destabilize the entire world.
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Daniel Gorelick @danielgorelick.bsky.social · 10/02/2025
Trainees who applied for an NIH diversity fellowship whose applications were withdrawn/not being reviewed, there's a NYTimes reporter who wants to talk, especially interested in applicants with disabilities. DM me & I'll put you in touch, will keep all contact confidential. Please amplify
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Irini Topalidou @irinakitop.bsky.social · 10/02/2025
"Keep calling, keep writing, Knowing you can always make a change for sure. That's what we're here for. Through good times and bad times, We'll stand by the side of research more. That's what we're here for." Bad but more modern version of "that's what friends are for"
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Reposted by Irini Topalidou
Chrystal Starbird @drstarbird.bsky.social · 10/02/2025
If only that breast cancer commercial ended with a notice about all the research funding cuts the current administration is pushing through and how it has immediate negative impacts on breast cancer research and screening.
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Irini Topalidou @irinakitop.bsky.social · 09/02/2025
As Christopher Hitchens said "never be a spectator of unfairness or stupidity. The grave will supply plenty of time for silence.” Now is the time for all of us to resist the absolute stupidity this government has imposed on our lives. www.washingtonpost.com/opinions/int...
washingtonpost.com
Opinion | The antidote to Trump despair is action. Here’s where to start.
Readers react to Anne Lamott’s op-ed on resistance and share strategies for fighting Trump 2.0.
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Reposted by Irini Topalidou
Buck Samuel 🪱🦠🧬🔬 @microbeminded.bsky.social · 07/02/2025
Very cool study on SKN-1/Nrf protein regulation of oxidative stress resistance by @nlehrbach.bsky.social lab in #Celegans
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Irini Topalidou @irinakitop.bsky.social · 09/02/2025
In the midst of the dark ages, we MUST retain optimism—keep going, keep publishing, keep talking science, and keep doing fun experiments! Our latest paper on the fascinating TF SKN-1/NRF presents exciting new findings using our one and only #Celegans #genetics #oxidativestress #proteasome
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Nick Burton @nickburton.bsky.social · 09/02/2025
#Celegans #Worms - I'm guessing sending whole labs to big conferences might be too expensive for many labs this year. I want to highlight this meeting will be FREE. VAI will cover all costs and lunch and if people still want night networking I will set something up if enough are interested.
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Reposted by Irini Topalidou
Michael Hoffman @michaelhoffman.bsky.social · 09/02/2025
That the White House feels the need to push back on this is good news. It means they are feeling the heat, and it's not just being seen as an inside baseball issue. Because it's not. Keep pushing! Keep calling! Keep fighting!
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Neil Shubin @neilshubin.bsky.social · 08/02/2025
Gene editing technology began by people studying salt marshes. Ozempic began by folks studying the venom of Gila Monsters. Support for basic science has empowered us to understand our world. Tethering it to applications health has transformed and saved countless lives.
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Irini Topalidou @irinakitop.bsky.social · 09/02/2025
👇😭
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Irini Topalidou @irinakitop.bsky.social · 08/02/2025
I’m reflecting on the many reasons immigrants like myself left their homes to come to this country—to join a scientific community built on innovation, creativity, freedom, and discovery. Trump, his supporters, and those who voted for him are destroying this incredible world 😢
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Irini Topalidou @irinakitop.bsky.social · 08/02/2025
A great 🧵 explaining why the new NIH directive felt like a bomb dropped on our heads 💣
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Elrond Hubbard @slimjw.bsky.social · 28/01/2025
I keep hearing "what can Dems do, they're not in power?" Here are four things they could do right now: (1/6) www.theguardian.com/commentisfree/2…
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John Collins @logicallyjc.bsky.social · 19/01/2025
I can’t wait to not watch the inauguration.
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Piali Sengupta @senguptalab.bsky.social · 26/11/2024
🧪 Lab's latest!! Work by PD (and now PI) Alison Philbrook. C. elegans sensory neurons have gorgeous #cilia. We’ve always thought that a) no cilia = no sensory responses, & b) no IFT = no cilia. Punchline is we thought wrong. Read paper for more! #neuroscience journals.plos.org/plosbiology/...
journals.plos.org
Cilia structure and intraflagellar transport differentially regulate sensory response dynamics within and between C. elegans chemosensory neurons
The relative contributions of intraflagellar transport (IFT) and cilia structure to sensory neuron responses remains unclear. This study reveals unexpected complexity in the contribution of IFT and ci...
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Reposted by Irini Topalidou
Aakanksha Singhvi @singhvilabglia.bsky.social · 26/11/2024
Hi worm world! We are looking for promoters that label hyp 4-6 (in any combination/subset). Do you have any leads? Have not gotten clean promoter bashed version from alr-1, so would love any help. Thank you in advance! #celegans #worm
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Irini Topalidou @irinakitop.bsky.social · 19/11/2024
WHY isn’t there a #Celegans day??!! Worm folks, what about we chose December 10 (the day that Brenner’s first paper “The genetics of C.elegans” was received by Genetics?)
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Irini Topalidou @irinakitop.bsky.social · 19/11/2024
👇🏻
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Irini Topalidou @irinakitop.bsky.social · 18/11/2024
I asked #ChatGPT to draw me a smiling #Celegans, and now every worm I pick feels like it's smiling at me 😋
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Irini Topalidou @irinakitop.bsky.social · 18/11/2024
This time of year is getting close, folks! Just saying.
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