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Marcos Castro e Silva, PhD 🇧🇷

@macscastro.bsky.social
189 followers 381 following 35 posts

Postdoc fellow at the Globe Institute @ucph.bsky.social • Interested in how genomics can help us understand human history and evolution • he/him macscastro.github.io

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Reposted by Marcos Castro e Silva, PhD 🇧🇷
Laura Vilà Valls @lvilavalls.bsky.social · 14/05/2026
A new popular science article on our genomic study in Sudan is now out in The Conversation Africa — check it out!
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Reposted by Marcos Castro e Silva, PhD 🇧🇷
Institut de Biologia Evolutiva (IBE) @ibe-barcelona.bsky.social · 07/05/2026
📣Heading South 📕The study led by Tábita Hünemeier (@hunemeier.bsky.social), principal investigator at the @ibe-barcelona.bsky.social, “Indigenous American genomes reveal unique diversity and evolution”, is featured on this week’s @nature.com cover. #UnravellingEvolution 👉
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Nature - Heading south
The last continent in the world to be settled by humans was the Americas. Beringia, a land bridge that replaced the Bering Strait during the last ice age,...
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Marcos Castro e Silva, PhD 🇧🇷 @macscastro.bsky.social · 07/05/2026
Our paper on the evolutionary history and genetic diversity of Indigenous Americans is featured on the cover of @nature.com
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Reposted by Marcos Castro e Silva, PhD 🇧🇷
UPF Medicine and Life Sciences @melisupf.bsky.social · 24/04/2026
#Research 🧬 The largest genetic database of the indigenous peoples of the Americas reveals over a million previously unknown variants A really interesting project led by Tábita Hünemeier, in which David Comas collaborated to help describe the contribution of the population they have named Ypykuéra
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Reposted by Marcos Castro e Silva, PhD 🇧🇷
Eleanor Scerri @elliescerri.bsky.social · 22/04/2026
1/5 Well over three years of work and I’m thrilled to see it out today in Science Advances: the cover feature no less! Using an innovative pipeline, we show that malaria shaped the spatial organization of human groups in sub-Saharan Africa over the last 74,000 years. www.science.org/doi/10.1126/...
science.org
Malaria shaped human spatial organization for the past 74 thousand years
Malaria has shaped human habitat choice, exchange, and dispersal since the late Pleistocene in sub-Saharan Africa.
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Reposted by Marcos Castro e Silva, PhD 🇧🇷
Tábita Hünemeier @hunemeier.bsky.social · 22/04/2026
Our new paper is out in @nature.com! By exploring the rich genetic diversity of Indigenous peoples across America, we show how large-scale genomic data reveal far more complex evolutionary history, shaped by multiple dispersals, long-term regional continuity, and adaptation to diverse environments.
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Reposted by Marcos Castro e Silva, PhD 🇧🇷
Eduardo Amorim @cegamorim.bsky.social · 22/04/2026
The largest and most diverse collection of Indigenous American genomes 👉🏻 “The evolutionary history and unique genetic diversity of Indigenous Americans” @macscastro.bsky.social @hunemeier.bsky.social @chiarabarbieri.bsky.social @jrockdrigo.bsky.social 🔗 www.nature.com/articles/s41...
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Marcos Castro e Silva, PhD 🇧🇷 @macscastro.bsky.social · 22/04/2026
🚨 Check out our new paper in Nature! In our new study, we sequenced 128 high-coverage genomes from Indigenous peoples across Latin America and uncovered their unique genetic diversity and history. 👇🧵 www.nature.com/articles/s41...
nature.com
The evolutionary history and unique genetic diversity of Indigenous Americans - Nature
Analysis of 128 high-coverage Indigenous American genomes shows extensive diversity shaped by several South American dispersals, ancient Australasian admixture, archaic introgression and long-term ada...
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Reposted by Marcos Castro e Silva, PhD 🇧🇷
Laura Vilà Valls @lvilavalls.bsky.social · 06/01/2026
Our new paper is out in PNAS! We analyzed 125 high-coverage whole genomes from five Sudanese ethnolinguistic groups, to understand the evolutionary and demographic history of the region. www.pnas.org/doi/10.1073/... 🧵👇
pnas.org
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
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Reposted by Marcos Castro e Silva, PhD 🇧🇷
Laura Vilà Valls @lvilavalls.bsky.social · 03/09/2025
Excited to share our new preprint🙌 It's the first human WGS study in Sudan. We uncover one of the strongest selection signals to date, pointing to post-admixture adaptation to malaria in Copts. Huge thanks to all co-authors. @aidaandres.bsky.social @jgarcia-cal.bsky.social @ebosch1972.bsky.social
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Reposted by Marcos Castro e Silva, PhD 🇧🇷
medRxivpreprint @medrxivpreprint.bsky.social · 03/09/2025
Sudan's complex genetic admixture history drives adaptation to malaria in Sudanese Copts www.medrxiv.org/content/10.1101/202…
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Reposted by Marcos Castro e Silva, PhD 🇧🇷
Chiara Barbieri @chiarabarbieri.bsky.social · 30/08/2025
A very special paper where we did something NEW! 🔥combining a large genetic dataset 🧬, a large linguistic dataset 💬, and Bayesian multilevel logistic regressions 📈, counting the effects of areal contact (geographic constrains) 🌎. Genetic admixture explains higher levels of linguistic exchanges...
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Reposted by Marcos Castro e Silva, PhD 🇧🇷
Alba Nieto Heredia @albanietoh.bsky.social · 16/06/2025
Seeing how every effort has now materialized into lessons and teachings that truly benefit @ibe-barcelona.bsky.social scientists of all generations has been immeasurable. Thank you, @xavimartiperez.bsky.social, for co-leading this project.
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Reposted by Marcos Castro e Silva, PhD 🇧🇷
Revista Pesquisa FAPESP @pesquisafapesp.bsky.social · 22/05/2025
Caçadores humanos podem ter sido os principais algozes das preguiças-gigantes. Análises evolutivas indicam que a disseminação de Homo sapiens pela América coincidiu com picos de extinção bit.ly/43dhPTf #paleontologia #biodiversidade #evolução #zoologia
bit.ly
Caçadores humanos podem ter sido os principais algozes das preguiças-gigantes
Imagine uma paisagem no Pantanal ou no Pampa, com suas amplidões de vegetação rasteira, entrecortada por imensos animais de até 4 toneladas, as preguiças-gigantes. No litoral, seria possível encontrar...
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Marcos Castro e Silva, PhD 🇧🇷 @macscastro.bsky.social · 16/05/2025
🚨 Our new paper is out in Science! We analyzed 2,723 high-coverage whole genomes from Brazilians to explore how five centuries of colonization, forced migration, and admixture have shaped genetic diversity and impacted health. 📄 science.org/doi/10.1126/... 🧵👇
science.org
Admixture’s impact on Brazilian population evolution and health
Brazil, the largest Latin American country, is underrepresented in genomic research despite boasting the world’s largest recently admixed population. In this study, we generated 2723 high-coverage who...
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Reposted by Marcos Castro e Silva, PhD 🇧🇷
Folha de S.Paulo @folha.com · 15/05/2025
Quase todos os brasileiros são miscigenados, diz estudo
www1.folha.uol.com.br
Maior análise de DNA já feita mostra que quase todos os brasileiros são miscigenados
Pesquisa também aponta herança indígena mais substancial do que se imaginava antes
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Reposted by Marcos Castro e Silva, PhD 🇧🇷
Eduardo Amorim @cegamorim.bsky.social · 15/05/2025
Very proud of my colleagues and friends for their amazing publication out in Science today! Nunes et al. "Admixture’s impact on Brazilian population evolution and health" www.science.org/doi/10.1126/... @hunemeier.bsky.social @macscastro.bsky.social 👏
science.org
Admixture’s impact on Brazilian population evolution and health
Brazil, the largest Latin American country, is underrepresented in genomic research despite boasting the world’s largest recently admixed population. In this study, we generated 2723 high-coverage who...
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