The actin cytoskeleton drives shape changes and transport in cells and supports mechanical signal transmission. However, how cells control and use active cytoskeletal flows at the mesoscale is not wel...

Cells migrating through three-dimensional (3D) tissues adapt their mechanical properties in response to extracellular matrix architecture through migratory plasticity. In primary human dermal fibrobla...

A new study led by researchers from Ben-Gurion University of the Negev (BGU) reveals that living matter violates previously known physical principles of symmetry when cellular flows form and break dow...

CFM enables tunable cell confinement for measuring traction forces exerted by single cells and cell aggregates in tissue-mimicking microenvironments.

Epithelial lumen formation is fundamental to organ development, yet how apical surfaces first emerge remains unclear. Ghosh, Martin, and Chen et al., show that lumen initiation is driven via bulk deli...

Zmuda et al. show that microscale defects on soft collagen-IV stall epithelial migration via filopodial sensing and intercellular communication of cytoskeletal disruption. Stiffer matrices, switching ...

Understanding how cells establish spatial organization within tissues is a fundamental question in life sciences. While modern three-dimensional fluorescence microscopy captures large-volume tissue ar...

Summary: A guide to mechanics in development: unlock how forces, material properties and geometry shape the forms of life.

In a new study, researchers at the Indian Institute of Science (IISc) have resolved a longstanding mystery by showing how epithelial tissues exhibit slow-moving, glass-like behavior despite their fast-paced biological activity.

Epithelial cell extrusion in a sea anemone shares key hallmarks with bilaterians and is dynamically regulated by nutritional status. During starvation-induced body shrinkage, extrusion likely contribu...

Proportional organ growth requires tissue-level control of cell behavior. Yet the cues that adapt growth rates, especially after organ injury, remain unclear. Here, we uncover that developing organs a...

Basement membranes are scaffolds of proteins, like collagen, that give organs shape. During development, basement membranes must adapt to the growing organ. We infer how fast the basement membrane ada...