iiinova — where your digital self keeps evolving

Timothy Saunders @timesaunders.bsky.social · 27/03/2025

Major pet conference peeve - speakers not speaking to time. It shortens breaks, reduces chances to engage ECRs and sets a bad precedent. Typically the bigger the name, the worse the timing.

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Reposted by Timothy Saunders

Cell Press @cellpress.bsky.social · 12/03/2025

Cells “speed date” to find their perfect neighbors when forming tissues. This marks a pivotal step in creating functional organs, like in this early heart development illustrated in a fly larvae. Learn more: www.cell.com/biophysj/ful... @timesaunders.bsky.social @biophysj.bsky.social

Fly embyro with cells labeled to show heart formation. The heart (cyan) forms from two distant regions of the embryo (far left). These regions migrate to the embryo midline, where they fuse into a tube to make the first heart structure (far right). Precise alignment and pairing of these cells are crucial for proper heart development.

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Campàs Lab @campaslab.bsky.social · 13/03/2025

👀 Looking for a Master Program in Physics of Life? Preferably free? Maybe in a collaborative and interdisciplinary environment? Check this out👇🏻

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Timothy Saunders @timesaunders.bsky.social · 13/03/2025

There’s been exciting work recently linking ideas from topology to biological systems. This has ranged from bird flocking (www.pnas.org/doi/full/10....), to gene networks (www.pnas.org/doi/full/10....), and now how nuclei pack in the Drosophila blastocyst (www.nature.com/articles/s41...).

pnas.org

Geometry of gene regulatory dynamics | PNAS

Embryonic development leads to the reproducible and ordered appearance of complexity from egg to adult. The successive differentiation of different...

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Timothy Saunders @timesaunders.bsky.social · 12/03/2025

Enjoyed doing this interview. Hope it's helpful for a more general audience.

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Timothy Saunders @timesaunders.bsky.social · 12/03/2025

Latest lab paper is out :) eur01.safelinks.protection.outlook.com?url=https%3A... With Sham Tlili, we show that a surprisingly simple equilibrium physics model can explain the highly dynamic process of cell matching in the heart.

eur01.safelinks.protection.outlook.com

ScienceDirect.com | Science, health and medical journals, full text articles and books.

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Timothy Saunders @timesaunders.bsky.social · 16/12/2024

Read about my amazing PhD student Ryan. Many thanks to CoB for hosting him for 3 months

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Reposted by Timothy Saunders

Rodrigo Fernandez-Gonzalez @rodrigofg.bsky.social · 19/11/2024

Since I have so many new friends 😄, I thought I'd advertise this. Together with @pritiagarwal.bsky.social and Lance Davidson, we run a Developmental Mechanics seminar series on Zoom (originally started by Ronen Zaidel-Bar). This coming Thursday, we have our last session for 2024. Join us!!

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Timothy Saunders @timesaunders.bsky.social · 17/11/2024

Tweetorial continued -unable to post more on the previous one: (ii) Bicoid could be produced in the oocyte, leading to early distribution of Bicoid (PMID: 28296637). (iii) Bicoid may not need to be degraded;dilution by nuclei could be sufficient to generate a gradient (PMID: 18001703) (10/22)

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Timothy Saunders @timesaunders.bsky.social · 17/11/2024

Our new focuses on translation of Bicoid during early Drosophila development (www.biorxiv.org/content/10.1...). We answer precisely when and where bicoid mRNA is translated. This helps us build an improved model of gradient formation. But, before going into results, first some background… (1/22)

biorxiv.org

Regulation of bicoid mRNA throughout oogenesis and early embryogenesis impacts protein gradient formation

The transcription factor Bicoid (Bcd) establishes patterning in the early Drosophila blastocyst through its graded concentration along the anterior-posterior (AP) axis. bcd mRNA is maternally deposite...

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Timothy Saunders @timesaunders.bsky.social · 17/11/2024

One thing I really liked about SciTwitter were the “tweetorials” on the latest papers – these really helped get a grip on new work, and also opened up potential research avenues that I would have otherwise missed. In this vein, I am about to try something similar here on BlueSky.

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Timothy Saunders @timesaunders.bsky.social · 08/11/2024

Amazed by the sudden increase in activity here following a certain event. Hopefully a strong community can build

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Timothy Saunders @timesaunders.bsky.social · 02/06/2024

A quick reminder that if you're n=2 SEM is meaningless. SEM is not a "trick" to make your error bars look smaller.

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Timothy Saunders @timesaunders.bsky.social · 16/04/2024

BSDB 2024. As usual, such a fun and welcoming meeting

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Timothy Saunders @timesaunders.bsky.social · 04/03/2024

My final (☹️) paper with Ivo Telley now out - doi.org/10.7554/eLif... I felt the elife system worked well - first time publishing there since the changed model. Good to have different approaches- nothing is perfect.

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Timothy Saunders @timesaunders.bsky.social · 14/02/2024

About to see Stornoway. My first gig since before I started my lab 😱

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Timothy Saunders @timesaunders.bsky.social · 13/02/2024

Really happy to see this out: journals.biologists.com/dev/article/... We use FCS to reveal that Bicoid dynamics vary spatially across the Drosophila embryo. We demonstrate this can explain previous observations about gradient extent and time scale of formation.

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Timothy Saunders @timesaunders.bsky.social · 15/01/2024

Just back from trip to Singapore. Realise I miss the place - a lot of fond memories. It was great catching up with people at NUS, NTU and A*Star

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Timothy Saunders @timesaunders.bsky.social · 15/12/2023

Day started with OneDrive deciding to delete >10,000files. It kept all the folders, just deleted the content 😭 Thankfully able to restore, but now have duplicates of all my folders - one empty and one with the actual contents.

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Timothy Saunders @timesaunders.bsky.social · 16/11/2023

Finally decided to move off the other site. Hope the science community finds a good home soon (hopefully here as put the effort to join and I'm too lazy to change again soon)

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