How do long-lived multipotent stem cells cope with mechanical stress in vivo?
We found that neural crest cells are protected from mechanical stress during migration in confined tissue environment.
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In vivo DNA damage protection during cell migration across confining embryonic tissue environments - Nature Cell Biology
Häkkinen et al. show that zebrafish neural crest cells encounter increased tissue-scale confinement along the body axis. Despite nuclear deformation, migrating neural crest cells experience neither nu...