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Zeitlinger Lab

@zeitlingerlab.bsky.social

239 followers 233 following 34 posts

Our long-term research goal is to understand and predict gene regulation based on DNA sequence information and genome-wide experimental data.

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Reposted by Zeitlinger Lab

Stowers Institute @stowersinstitute.bsky.social · 25/08/2026

(1/2) NEW #research published Nature Communications: Scientists in the @zeitlingerlab.bsky.social developed PISA, a new AI interpretation method that lets researchers see, at high resolution, what #AI models learn from #DNA sequences. 🧬 ⬇️

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Zeitlinger Lab @zeitlingerlab.bsky.social · 05/02/2026

The new updates for Charles McAnany’s preprint “Positional Interpretation of Cis-Regulatory Code and Nucleosome Organization with Deep Learning Models” (www.biorxiv.org/content/10.1...) are up! We introduce PISA, a tool to visualize the cis-regulatory code. See a recap below:

biorxiv.org

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Zeitlinger Lab @zeitlingerlab.bsky.social · 09/01/2026

The @zeitlingerlab.bsky.social is pleased to announce @sergio-gma91.bsky.social’s preprint “High-resolution binding data of TFIID and cofactors show promoter-specific differences in vivo” (www.biorxiv.org/content/10.6...). TLDR; TFIID behaves differently depending on promoter type. More below:

biorxiv.org

High-resolution binding data of TFIID and cofactors show promoter-specific differences in vivo

TFIID is instrumental in recognizing promoter sequences and initiating transcription, yet a cohesive understanding of how this complex interacts with and functions at different promoter types in vivo ...

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Zeitlinger Lab @zeitlingerlab.bsky.social · 19/11/2025

We are pleased to announce a new preprint by @mlweilert.bsky.social: “Widespread low-affinity motifs enhance chromatin accessibility and regulatory potential in mESCs” (www.biorxiv.org/content/10.1...). See summary and longer recap below: (TLDR; low-affinity motifs matter as pioneers!)

biorxiv.org

Widespread low-affinity motifs enhance chromatin accessibility and regulatory potential in mESCs

Low-affinity transcription factor (TF) motifs are an important element of the cis-regulatory code, yet they are notoriously difficult to map and mechanistically incompletely understood, limiting our a...

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Zeitlinger Lab @zeitlingerlab.bsky.social · 19/09/2025

Excited to join Bluesky! Looking forward to seeing the cool research everyone posts!

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