iiinova — where your digital self keeps evolving

Reposted by Saori Sakaue

William DeWitt @wsdewitt.github.io · 05/06/2026

This started in 2019 as daydreamy PhD student musings with Tatsuya Araki. We're as excited as ever about germinal centers as a platform for experimental evolution. Many thanks to PIs @victora.bsky.social @matsen.bsky.social, co-1st authors Ashni Vora and Tatsuya, and many other key collaborators!

cell.com

Replaying germinal center evolution on a quantified affinity landscape

Antibody affinity maturation results from a somatic evolutionary process that takes place in the germinal center. A “parallel replay” experiment on germinal center B cells reveals the evolutionary for...

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Reposted by Saori Sakaue

Sudarshan Pinglay @sudpinglay.bsky.social · 04/06/2026

How much of the human genome is essential? Two pieces out today from our lab: 1) a method to map essential genomic intervals at gigabase scale, and 2) an argument that it's time to consider synthesizing a minimal human genome. biorxiv.org/content/10.6... nature.com/articles/d41...

nature.com

Why a synthetic human genome is still worth building

A decade on from the launch of an ambitious project, it’s time to revisit the reasons for constructing a human genome from scratch.

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Saori Sakaue @saorisakaue.bsky.social · 28/04/2026

New preprint! 📣We performed the largest multi-ancestry GWAS of rheumatoid arthritis (RA), the most common autoimmune disease, by analyzing the VA Million Veteran Program (MVP) with international RA cohorts.

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Saori Sakaue @saorisakaue.bsky.social · 28/04/2026

An important piece from my neighbor, colleague and friend Will DeWitt et al. @wsdewitt.github.io www.biorxiv.org/content/10.6...

biorxiv.org

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Reposted by Saori Sakaue

Maitreya Dunham @maitreya.bsky.social · 24/11/2025

Open faculty position (Assistant or Associate) in UW Medical Genetics. As you might expect, faculty often end up also interacting with Genome Sciences, so we're hoping for some great prospects! Note the clinical requirements for the position. apply.interfolio.com/176466

apply.interfolio.com

Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio

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Reposted by Saori Sakaue

loic-yengo.bsky.social @loic-yengo.bsky.social · 12/11/2025

First time on Bsky and first big announcement! I am excited to announce that our new study explaining the missing heritability of many phenotypes using WGS data from ~347,000 UK Biobank participants has just been published in @Nature. Our manuscript is here: www.nature.com/articles/s41....

nature.com

Estimation and mapping of the missing heritability of human phenotypes - Nature

WGS data were used from 347,630 individuals with European ancestry in the UK Biobank to obtain high-precision estimates of coding and non-coding rare variant heritability for 34 co...

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Saori Sakaue @saorisakaue.bsky.social · 14/10/2025

I’ll be at #ashg2025 ! Please let me know if you want to chat with me about research, my lab at UW saorisakaue.github.io etc etc! I’ll also be standing at the poster session on Friday 5075F at 2:30-4p if you can swing by to chat👋

saorisakaue.github.io

Home - Sakaue Lab @ Genome Sciences, UW

Lab website for Dr. Saori Sakaue

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Reposted by Saori Sakaue

Nobu Hamazaki @nobuhamazaki.bsky.social · 26/09/2025

New paper from my lab and @jshendure.bsky.social lab! Led by the brilliant @zukailiu.bsky.social and @cxqiu.bsky.social. We tackled how anterior and posterior progenitor cells cooperate to self-organize into an embryonic structure (termed AP-gastruloid). (1/n) www.biorxiv.org/content/10.1...

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Saori Sakaue @saorisakaue.bsky.social · 27/02/2025

📣Excited to share my last postdoc paper with @soumya-boston.bsky.social on eQTL mechanisms depending on where the RNA is in the cell! @broadinstitute.org @harvardmed.bsky.social TL;DR:Early RNA eQTL variants in the nucleus and late RNA eQTL variants in the cytosol have distinct molecular mechanism🧵

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