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Riddhiman Garge

@riddhiman.bsky.social
271 followers 539 following 30 posts

K99/R00 Fellow w/ @jshendure.bsky.social, @leastarita.bsky.social & @dschweppe.bsky.social | @uwgenome.bsky.social, @cegs-cmap.bsky.social & @brotmanbaty.bsky.social |PhD w/ @edwardmarcotte.bsky.social |Musician, vinyl collector, RCB & Utd outside the lab.

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Reposted by Riddhiman Garge
Jay Shendure @jshendure.bsky.social · 31/07/2026
Thrilled to post thread re: new single-cell lineage of mouse embryo reconstructed w/ DNA Typewriter. One animal, zygote to late organogenesis (E13.5). Tree has 1,340,794 transcriptionally profiled, annotated tips (cells), 1,142,588 dated internal nodes, rooted at zygote 1/n
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Reposted by Riddhiman Garge
Jay Shendure @jshendure.bsky.social · 30/07/2026
New preprint from Shendure Lab on Locus-Scale aka Long-@$$ MPRAs led by the amazing Abby McGee & @carinabiar.bsky.social Most MPRAs test ~300 bp fragments next to a promoter. But real enhancers are bigger, act combinatorially and from a distance. 1/n www.biorxiv.org/content/10.6...
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Reposted by Riddhiman Garge
Sudarshan Pinglay @sudpinglay.bsky.social · 04/06/2026
How much of the human genome is essential? Two pieces out today from our lab: 1) a method to map essential genomic intervals at gigabase scale, and 2) an argument that it's time to consider synthesizing a minimal human genome. biorxiv.org/content/10.6... nature.com/articles/d41...
nature.com
Why a synthetic human genome is still worth building
A decade on from the launch of an ambitious project, it’s time to revisit the reasons for constructing a human genome from scratch.
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Reposted by Riddhiman Garge
Nature Cell Biology @natcellbio.nature.com · 11/05/2026
☕ @riddhiman.bsky.social et al. use experimentally matched mass-spec and RNA-seq to quantify proteins, phosphosites & transcripts across 4 stages of human & mouse gastruloid development. @jshendure.bsky.social @leastarita.bsky.social @nobuhamazaki.bsky.social @dschweppe.bsky.social bit.ly/4dAYyA1
bit.ly
The proteomic landscape and temporal dynamics of human and mouse gastruloid development - Nature Cell Biology
Garge et al. use experimentally matched mass spectrometry and RNA-sequencing to quantify proteins, phosphosites and transcripts across four key stages of human and mouse gastruloid development.
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Reposted by Riddhiman Garge
Devin Schweppe @dschweppe.bsky.social · 24/04/2026
Excited to see @riddhiman.bsky.social's gastruloid multiomics paper out now at Nature Cell Bio! Riddhiman used proteomics, phosphoproteomics, and RNAseq to profile stem-cell-derived embryo models to identify protein, complex, and signaling regulators of development. www.nature.com/articles/s41...
nature.com
The proteomic landscape and temporal dynamics of human and mouse gastruloid development - Nature Cell Biology
Garge et al. use experimentally matched mass spectrometry and RNA-sequencing to quantify proteins, phosphosites and transcripts across four key stages of human and mouse gastruloid development.
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Reposted by Riddhiman Garge
Alfonso Martinez Arias @amartinezarias.bsky.social · 25/04/2026
Previously a #preprint, now a peer reviewed @dschweppe.bsky.social work a fine, insightful, useful reference for the growing #gastruloid community . Proteomics, protein-RNA discordances, mouse-human comparison www.nature.com/articles/s41... Insights into human embryos for a growing #SCBEM community
nature.com
The proteomic landscape and temporal dynamics of human and mouse gastruloid development - Nature Cell Biology
Garge et al. use experimentally matched mass spectrometry and RNA-sequencing to quantify proteins, phosphosites and transcripts across four key stages of human and mouse gastruloid development.
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Riddhiman Garge @riddhiman.bsky.social · 25/04/2026
1/ Thrilled to share our latest: an exciting collaboration across the @jshendure.bsky.social, @leastarita.bsky.social, @nobuhamazaki.bsky.social and @dschweppe.bsky.social labs! 🧵 below- #SystemsBiology #SCBEM #MultiOmics #Gastruloids www.nature.com/articles/s41...
nature.com
The proteomic landscape and temporal dynamics of human and mouse gastruloid development - Nature Cell Biology
Garge et al. use experimentally matched mass spectrometry and RNA-sequencing to quantify proteins, phosphosites and transcripts across four key stages of human and mouse gastruloid development.
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Reposted by Riddhiman Garge
Saccharomyces Genome Database @yeastgenome.bsky.social · 02/03/2026
We are deeply saddened to share the news of the passing of David Botstein, a towering figure in modern #genetics and a foundational force behind SGD. www.yeastgenome.org/blog/in-memo... #yeast #modelOrganism
a headshot of David Botstein
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Gavin Sherlock @gsherloc.bsky.social · 28/02/2026
I was sad to learn that my postdoctoral mentor, David Botstein, died yesterday. I started with David as a postdoc in 1998, and he had a profound effect on both my life and scientific career. He was a giant in the field of genetics, making seminal contributions in both yeast and human genetics. 1/
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Carl Zimmer @carlzimmer.com · 18/02/2026
Scientists have seen Asgard archaea crawling for the first time. When it comes to the origin of eukaryotes, this is like seeing a feathered dinosaur in the wild. (Video courtesy of Philipp Ralder)
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Riddhiman Garge @riddhiman.bsky.social · 22/11/2025
Very happy to share our latest led by the relentless @shawnfayer.bsky.social! We developed multiplexed assays to measure variant effects across diverse genetic and cell contexts in stem cell and differentiated cells. 🧵 👇
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Reposted by Riddhiman Garge
allen institute @alleninstitute.org · 20/10/2025
Congratulations to Karel Svoboda and @jshendure.bsky.social on their election to the National Academy of Medicine (@nam.edu)! Election to the Academy is one of the highest honors in health and medicine. #NAMmtg More on their journeys to this achievement: alleninstitute.org/news/karel-s...
alleninstitute.org
Karel Svoboda and Jay Shendure elected to National Academy of Medicine
The honor recognizes leaders who have demonstrated outstanding achievement and made lasting contributions to the advancement of the medical sciences, health care, and public health
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Reposted by Riddhiman Garge
Jay Shendure @jshendure.bsky.social · 14/10/2025
Super excited about first Shendure/Baker Lab collaboration & preprint on a multiplex sequencing-based strategy for screening de novo proteome editors in mammalian cells. Kudos to the brilliant Chase Suiter (not here) & @greenahn.bsky.social on the work! Preprint here: www.biorxiv.org/content/10.1...
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Nobu Hamazaki @nobuhamazaki.bsky.social · 26/09/2025
New paper from my lab and @jshendure.bsky.social lab! Led by the brilliant @zukailiu.bsky.social and @cxqiu.bsky.social. We tackled how anterior and posterior progenitor cells cooperate to self-organize into an embryonic structure (termed AP-gastruloid). (1/n) www.biorxiv.org/content/10.1...
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Sri Kosuri @srikosuri.bsky.social · 08/02/2025
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
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Reposted by Riddhiman Garge
Sudarshan Pinglay @sudpinglay.bsky.social · 31/01/2025
Now out in @science.org w/ @jshendure.bsky.social we present 'Genome-shuffle-seq': a method to shuffle mammalian genomes and characterize the impact of structural variants (SVs) with single-cell resolution in one experiment. www.science.org/doi/10.1126/...
science.org
Multiplex generation and single-cell analysis of structural variants in mammalian genomes
Studying the functional consequences of structural variants (SVs) in mammalian genomes is challenging because (i) SVs arise much less commonly than single-nucleotide variants or small indels and (ii) ...
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Riddhiman Garge @riddhiman.bsky.social · 10/05/2024
Thanks GSA for blogging about our work!
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Reposted by Riddhiman Garge
Maitreya Dunham @maitreya.bsky.social · 07/03/2024
How appropriate that our G3 paper with @riddhiman.bsky.social and @edwardmarcotte.bsky.social et al came out in final form while I'm at #TAGC24! Systematic profiling of ale yeast protein dynamics across fermentation and repitching academic.oup.com/g3journal/ar...
academic.oup.com
Systematic profiling of ale yeast protein dynamics across fermentation and repitching
Abstract. Studying the genetic and molecular characteristics of brewing yeast strains is crucial for understanding their domestication history and adaptations a
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Riddhiman Garge @riddhiman.bsky.social · 14/12/2023
Very grateful to be amongst this amazing cohort of scientists! Many thanks to @wrfseattle for the opportunity to learn and grow in this diverse program. Finally, I can't thank my mentors @jshendure.bsky.social and @lea_starita at UW Genome Sciences enough for their support!
wrfseattle.org
Washington Research Foundation announces its largest ever cohort of WRF Postdoctoral Fellows for 202...
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Riddhiman Garge @riddhiman.bsky.social · 23/09/2023
Finally on BlueSky! Thrilled to share our work profiling Ale yeast protein dynamics across fermentation and serial repitching! biorxiv.org/content/10.1... @maitreya.bsky.social @edwardmarcotte.bsky.social @LiveOakBrewing #BeerYeast #SystemsBiology #Proteomics Sneek Peak🧵 below-
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Maitreya Dunham @maitreya.bsky.social · 22/09/2023
Super fun project with @riddhimankg (twitter), @edwardmarcotte.bsky.social, @LiveOakBrewing (twitter), and friends! Systematic Profiling of Ale Yeast Protein Dynamics across Fermentation and Repitching www.biorxiv.org/content/10.1...
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