Nature Protocols, Published online: 21 September 2026; doi:10.1038/s41596-026-01416-zThis Protocol uses retrograde axonal tracing and fluorescence-activated cell sorting to transcriptionally profile innervating neurons at single-cell resolution.

Forschende vom Deutschen Krebsforschungszentrum (DKFZ) und von Stammzell-Institut HI-STEM haben einen bislang unbekannten Mechanismus identifiziert, mit dem eine besonders aggressive Form von Darmkreb...

Researchers from the German Cancer Research Center (DKFZ) and the HI-STEM* Stem Cell Institute have identified a previously unknown mechanism by which a particularly aggressive form of colon cancer ev...

In vivo ligation of clinically used therapeutic antibodies via bioorthogonal click chemistry to antibody–drug conjugates leads to enhanced antitumour activity in heterogeneous and treatment-resistant ...

A ketogenic diet promotes tumour growth in the small intestine in susceptible mice. In people, diet advice might need to be tailored to individual cancer risks.

A combination of different manipulations in mouse models of spontaneous intestinal adenoma formation dissects the roles of systemic and epithelial ketogenesis versus dietary lipids in ketoge...

Through its “Proof of Concept” (PoC) grants, the European Research Council (ERC) supports scientists in further developing the economic potential of their research findings. In 2026, two scientists fr...

In this review, Pistilli et al. examine persistent challenges in antibody-drug conjugate (ADC) development, including patient selection, biomarker validation, and preclinical modeling. Integrating emerging insights into tumor biology, resistance, and microenvironmental effects, the authors propose reframing ADCs as tumor-ecosystem-targeting therapies and outline paths to embed ADCs within precision oncology.

The ability of cancer cells to change their identity makes tumors such as glioblastoma particularly aggressive and resistant to treatment. Moritz Mall, of the German Cancer Research Center (DKFZ) and ...

Jimenez-Castaño and Nieto review the latest research on cellular plasticity associated with epithelial–mesenchymal transition (EMT) states in cancer cells, highlighting the contributions of EMT to tum...

Chemotherapy is often a central component of treatment for advanced colorectal cancer. However, not every therapy is equally effective for every patient. Researchers from the German Cancer Research Ce...

Antibody–drug conjugates are rapidly expanding both in the clinical treatment of cancer and in preclinical development. In this Review, Zippelius et al. highlight the molecular interactions and immune system effects of these sophisticated drugs that drive their efficacy and toxicity.

Metient is a statistical framework that infers patterns of metastatic spread and reconstructs cancer migration histories.

The Center for Molecular Biology of Heidelberg University (ZMBH) and the Faculty of Biosciences invite applications for a   Tenure Track Professors...

HETEROGENEITE ET PLASTICITE TUMORALE : LES NOUVELLES TECHNOLOGIES POUR EXPLORER L’ECOSYSTEME TUMORAL 8e SESSION DE FORMATION DU RESEAU SUNRiSE 2 au 3 mars 2026, On line Objectif : Cette formation se d...

View details and apply for this Postdoctoral Training Fellow - Genomics and Evolutionary Dynimcs vacancy in Sutton. Salary: Dependent on relevant Postdoctoral experience. Durati...

Job Purpose To take a senior leadership role by conducting internationally leading research, with specific interests in cancers of epithelial origin, the role of epithelial stem cells in tissue hom...

The 6th Sunrise Meeting

The 2025 MRS Early Career Research Virtual Meeting is a two day meeting aimed at engaging trainees and early career researchers from around the world and highlighting recent advances in metastasis research through keynote presentations, invited talks, panel discussions, and selected talks from abstracts. The meeting is organized and hosted by the Early Career Leadership Council (ECLC) of the MRS. Abstracts are being accepted for consideration for oral presentations. Abstract submission is open to graduate students, postdoctoral fellows, medical students, residents, clinical fellows, and researchers within 3 years of starting their own independent research group. Registration for this meeting is free for MRS Members!

This study nominates immune escape as an early event in colorectal cancer and shows how this can be driven through both genetic and epigenetic changes.