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Simon Haas

@simonhaas.bsky.social
164 followers 41 following 22 posts

Professor at BIH@Charité, MDC and PHURI@QMUL

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Reposted by Simon Haas
Lars Velten @larsplus.bsky.social · 04/09/2026
It's been preprint week! Joe's great Perturb-seq story "back-to-back" with our single cell AML atlas (led by @simonhaas.bsky.social). 🤒: www.biorxiv.org/content/10.6... 🧬: www.biorxiv.org/content/10.6... These two apparently very different stories were posted back to back because of a surprise 😮🧵:
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Nature Cell Biology @natcellbio.nature.com · 24/06/2026
☕Single-cell transplantations of long-term HSCs, in-depth phenotyping and mathematical modeling identify reconstitution kinetics as a unifying metric of HSC potency and extrinsic regulation as a driver of lineage bias. @simonhaas.bsky.social @milsommick.bsky.social www.nature.com/articles/s41...
nature.com
A kinetics-based model of haematopoiesis reveals extrinsic regulation of skewed lineage output from stem cells - Nature Cell Biology
Single-cell transplantations of long-term haematopoietic stem cells (HSCs), in-depth phenotyping and mathematical modelling identify reconstitution kinetics as a unifying metric of HSC potency and ext...
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Simon Haas @simonhaas.bsky.social · 04/09/2026
1/4 🧬 New preprint from the lab! Can future clinical trajectories in AML already be read at diagnosis? We assembled single-cell multi-omics data from 184 AML patients across all known subtypes, linked to deep clinical outcome data. 🧵 www.biorxiv.org/content/10.6...
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Max Delbrück Center @mdc-berlin.bsky.social · 24/06/2026
Imagine testing cancer therapies on patient-derived organoids before treatment begins. At the #mdcBerlin Bioengineering Symposium, researchers will discuss how bioengineering is bringing medicine closer to that future. 🗓️ July 6 | Berlin-Buch More details: 👉 www.mdc-berlin.de/news/press/j... 👈
Graphic for the Max Delbrück Center Bioengineering Symposium 2026 featuring a fluorescent microscopy image in blue, green, and red. Overlaid text reads: “Bioengineering Symposium Final Call” and “July 6, 2026 | Berlin-Buch.” The Max Delbrück Center logo appears in the bottom right-hand corner. The graphic serves as a final invitation to attend the symposium.
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Mick Milsom @milsommick.bsky.social · 25/05/2026
How do lineage-biased HSC states relate to each other? check out: rdcu.be/fkASJ in @natcellbio.nature.com Collaboration with @simonhaas.bsky.social @bihatcharite.bsky.social & MDC; Thomas Höfer & Daniel Hübschmann @dkfz.bsky.social @nct-heidelberg.bsky.social
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Simon Haas @simonhaas.bsky.social · 26/05/2026
In our new study, we identify stem cell kinetics and cellular competition as key principles underlying hematopoietic stem cell diversity. Fun collab@milsommick.bsky.social Florian Grünschläger@estherrodriguezc.bsky.social, Tamar Nizharadze, T. Höfer, D. Hübschmann(1/6) www.nature.com/articles/s41...
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Max Delbrück Center @mdc-berlin.bsky.social · 26/03/2026
In aggressive #lymphomas, inflammatory messengers reprogram the ​“conductors” of the immune system, causing lymph node structure to collapse. A team led by @simonhaas.bsky.social describes this process in ​“Nature Cancer” using #singlecell and spatial analyses: www.mdc-berlin.de/news/press/c...
scientific image. Text: "Chaos in lymph nodes promotes cancer"
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Simon Haas @simonhaas.bsky.social · 10/12/2025
📢 ISCO registration is now open for registration! Everyone interested in the latest developments in single-cell approaches and their applications will enjoy our exciting lineup of speakers. 🌞 Join us in sunny Barcelona this May!
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Reposted by Simon Haas
Nature Methods @natmethods.nature.com · 07/08/2025
Interact-omics is a high-throughput cytometry-based framework for cellular interaction mapping. @simonhaas.bsky.social www.nature.com/articles/s41...
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Viktoria Flore @viktoriaflore.bsky.social · 07/08/2025
Did you ever wonder what insights hide in the multiplets that are usually discarded in flow cytometry? 🫧 Find out in the first publication of my PhD, now out in Nature Methods! www.nature.com/articles/s41... (1/4)
nature.com
Ultra-high-scale cytometry-based cellular interaction mapping - Nature Methods
Interact-omics, a high-throughput cytometry-based framework, resolves the cellular interaction landscape.
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MDC-BIMSB @mdc-bimsb.bsky.social · 07/08/2025
Great opportunity! Up to 4 Group Leader positions at the NOVA Institute for Medical Systems Biology (NIMSB) in Computational & Experimental Medical Systems Biology 📍 Lisbon ⏳ Apply by Oct 8 🔗 nimsb.unl.pt/wp-content/u... #Job #SciencePositions #JobOffer #GroupLeaders #Innovation #systemsbiology
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Simon Haas @simonhaas.bsky.social · 07/08/2025
Excited to share our latest paper @natmethods.nature.com We present a high-throughput framework to map cellular interactions at ultra-high scale – broadly applicable from whole-organism immune response mapping to personalized therapy response prediction (1/4). www.nature.com/articles/s41...
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Itai Yanai @itaiyanai.bsky.social · 27/02/2025
"Innovations in Single Cell Omics" Berlin 5.12-13. Organizers: @stefaniegrosswendt.bsky.social @simonhaas.bsky.social @leifludwig.bsky.social Ashley Sanders @larsplus.bsky.social @elimereu.bsky.social @alejofraticelli.bsky.social
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Max Delbrück Center @mdc-berlin.bsky.social · 24/02/2025
A group of Berlin researchers and international colleagues have found differences in heart inflammation caused by COVID-19, vaccination, and heart disease. The results pave the way for more personalized therapies, they report in "Nature Cardiovascular Research.” ➡️ www.mdc-berlin.de/news/press/n... ⬅️
Microscopic image of heart cells glowing green and blue, with the caption "Not all heart inflammation is the same" written in white letters across the bottom of the graphic.
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Reposted by Simon Haas
Max Delbrück Center @mdc-berlin.bsky.social · 11/02/2025
Zooming in on how multiple myeloma starts to spread in the body: Single-cell analyses and spatial omics allowed international researchers, including the @simonhaas.bsky.social lab at the #mdcBerlin, to see a co-evolution of blood cancer and immune cells. #ScienceImmunology More details 👇
mdc-berlin.de
When blood cancer starts to spread
When blood cancer cells break through the bone and multiply, tumor cells become dangerously diverse and the immune response in the region changes, researchers from Berlin and Heidelberg report in “Sci...
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Reposted by Simon Haas
Sheela Abraham @haemev.bsky.social · 08/02/2025
Super intriguing findings
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Simon Haas @simonhaas.bsky.social · 08/02/2025
Great opportunity to learn more about the most recent possiblities on single-cell lineage tracing!!! Attend a workshop led by one of the key experts in the field @leifludwig.bsky.social Join us at the ISCO2025 conference!
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Reposted by Simon Haas
Mike Spencer Chapman @mikespencerchapman.bsky.social · 15/01/2025
So pleased to have the paper out, available here: www.nature.com/articles/s41586-024-08423-8 For me this was discovery science as I had always hoped it would be. A lot of fun, and some proper detective work with plenty of twists & turns on the way. Brief thread below
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MDC-BIMSB @mdc-bimsb.bsky.social · 27/01/2025
Join us to connect with the vibrant #singlecell community. 📢Register for the #ISCO'25 Conference "Innovations in #SingleCell #OMICS" in Berlin! 🗓️ 12-13 May 2025 🎤 fantastic Keynote and Confirmed Speakers 🫵🏿 Many slots for talks: submit your abstract 🔗http://isco-conference.eu
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Simon Haas @simonhaas.bsky.social · 08/02/2025
Curious about the latest innovations in single-cell omics? 🔬✨ Join us at the next ISCO conference for groundbreaking insights, exciting speakers, and plenty of fun! Don't miss it! 🗓️ 12-13 May 2025 🔗http://isco-conference.eu
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Reposted by Simon Haas
Leif S. Ludwig @leifludwig.bsky.social · 31/01/2025
Join us to connect with the vibrant #singlecell community. 📢Register for the #ISCO'25 Conference "Innovations in #SingleCell #OMICS" in Berlin! 🗓️ 12-13 May 2025 🎤 Fantastic Keynote and Invited Speakers 🫵🏿 Many slots for talks: submit your abstract 🔗http://isco-conference.eu Please spread the word!
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Leif S. Ludwig @leifludwig.bsky.social · 31/01/2025
Interested in 'Mitochondrial single cell-multi-omics for lineage tracing and genetics'? Apply for our free workshop in Berlin following our #ISCO2025 conference! www.isco-conference.eu www.mdc-berlin.de/news/events/...
mdc-berlin.de
Mitochondrial single cell-multi-omics for lineage tracing and genetics
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Simon Haas @simonhaas.bsky.social · 08/02/2025
How does multiple myeloma progress? In our latest Science Immunology cover story, we reveal how myeloma cells breaking through bone trigger dangerous diversity. This arises from bidirectional interactions with the immune system, fueling disease evolution. scim.ag/4hMrLHs 1/2
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Simon Haas @simonhaas.bsky.social · 08/02/2025
Be sure to check out the fantastic tweetorial by @milsommick.bsky.social on our collaborative work uncovering the sources of hematopoeitic stem cell heterogeneity 🔥
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Simon Haas @simonhaas.bsky.social · 08/02/2025
Ever wondered what drives hematopoietic stem cell (HSC) heterogeneity? In this preprint, our collaborative team uncovered that differences in HSC reconstitution kinetics play a key role in shaping stem cell heterogeneity and lineage biases. doi.org/10.1101/2025... (1/2)
doi.org
A kinetics-based model of hematopoiesis reveals extrinsic regulation of skewed lineage output from stem cells
Residing at the top of the hematopoietic hierarchy, long-term hematopoietic stem cells (HSCs) are capable of self-renewal and sustained blood cell regeneration. Over the past decades, single-cell and ...
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