We introduce our Series on Next-generation cancer therapeutics with commissioned Reviews, Perspectives and opinion pieces on the latest advances in targeted ...

Chen and colleagues report that the neuropeptide galanin impairs antitumor immunity in glioblastoma by interacting with its receptor GALR3 on monocytic myeloid-derived suppressor cells, promoting thei...

Swanton and colleagues provide an overview on intratumor heterogeneity and cancer evolution arising from genetic factors and non-genetic regulation of cancer cells, the tumor microenvironment and the ...

Hu and colleagues report that a micropeptide encoded by the lncRNA USP30-AS1 promotes tumor growth by undergoing phase separation with TBK1 and attenuating cGAS–STING–type I IFN signaling in tumor-ass...

In the multicenter, single-arm, open-label, first-in-human phase 1 NOA16 trial, Platten and colleagues report the long-term clinical and immunological follow-up outcomes of a vaccine targeting mutant ...

Target discovery remains a considerable challenge in the development and translation of chimeric antigen receptor (CAR)-T cell therapies for solid tumors. Two reports in Nature and Nature Cancer now d...

Huang and colleagues report that elevated iron levels are associated with ferroptosis of chimeric antigen receptor (CAR)-T cells and inhibition of ferroptosis improves antitumor efficacy of CAR-T cell...

Jin et al. developed an artificial intelligence tool that leverages histology to predict methylation-based central nervous system tumor subtypes and validated it for tumor classification, demonstratin...

In a large cohort of participants with immune-checkpoint-blockade-treated glioblastoma, Ghannam et al. show that baseline mesenchymal transcriptional state predicts therapy response and transition to ...

In a large cohort of participants with immune-checkpoint-blockade-treated glioblastoma, Ghannam et al. show that baseline mesenchymal transcriptional state predicts therapy response and transition to ...

Zhao and colleagues show that CD300ld, upregulated in pathologically activated neutrophils, mediates contact-dependent suppression of cytotoxic CD8+ T cells by binding to phosphatidylserine, inhibitin...

Gabrilovich and colleagues provide an overview of myeloid cell plasticity during differentiation, within the tumor microenvironment and in response to therapy, and discuss the challenges to therapeuti...

Johanns and colleagues report the results (including safety, efficacy and immunogenicity) of a phase 1 clinical trial of a DNA-based personalized therapeutic cancer vaccine administered following surg...

Tan and colleagues discuss recent advances in spatial omics and computational models that inform the classification and clinical relevance of cellular neighborhoods in cancer.

In this paper, Steeghs and colleagues report the safety, activity, pharmacokinetic and pharmacodynamic results of a phase 1 dose-escalation trial with MP0317 (FAP x CD40 DARPin) monotherapy in patients with advanced solid tumors.

Sherman and colleagues provide an overview of the current understanding of the heterogeneity and plasticity of cancer-associated fibroblasts.

Jimenez-Castaño and Nieto review the latest research on cellular plasticity associated with epithelial–mesenchymal transition (EMT) states in cancer cells, highlighting the contributions of EMT to tum...

With this collection, Nature Communications, Nature, Nature Cancer, Nature Neuroscience, Nature Progress Oncology, Nature Progress Brain Health, and ...

Emmett and colleagues evaluate the frequency, magnitude and clinical significance of early prostate-specific membrane antigen (PSMA) upregulation in patients with metastatic castrate-resistant prostat...

Li et al. conduct a multi-omics analysis of nasopharyngeal carcinoma and identify three molecular subtypes with distinct immune profiles and responses to induction chemotherapy.

Gfeller et al. discuss the recent technological and computational advances in prediction of TCR–epitope recognition and the therapeutic applications in cancer immunotherapy.

Izar and colleagues review the insights into cancer biology gained via single-cell analyses and spatial profiling and overview the challenges and opportunities associated with the implementation of th...

Huang, Hou, Yang et al. demonstrate that leptomeningeal metastatic cells favor the formation of a premetastatic niche by remodeling the choroid plexus vasculature through the serotonin metabolite 5-hy...

Li et al. present PRET, a few-shot system for pan-cancer detection not requiring model fine-tuning, validated it in multicenter datasets and found that it outperformed existing approaches across tasks...

Czernilofsky et al. identified factors that reprogram stromal cells into an inflammatory, dysfunctional state, leading to the structural disorganization of lymph nodes in B cell lymphoma at single-cel...

Murthy and colleagues discussed recent research on the effect of a tucanitib–trastuzumab–capecitabine regimen in patients with HER2+ breast cancer and leptomeningeal metastasis.

Job Title: Associate or Senior Editor, Nature Cancer Location: Beijing, Madrid, Nanjing or Shanghai - Hybrid working model  Applications Deadline: 29th March About Springer Nature Springer Nature is o...

Zeng et al. analyzed cfDNA methylation and fragmentomic data from 1,294 patient plasma samples across 14 major cancer types to present a comprehensive landscape of pancancer and cancer-specific cell-f...

Ranek et al. developed a computational method that analyzes proteomic imaging and detects differentially enriched cellular niches, including low-prevalence niches. They applied this tool to inform the...

Smith et al. present M-PACT, a deep neural network leveraging low-input cell-free DNA methylation profiles to achieve robust classification of pediatric brain tumors and enable cellular deconvolution ...

The European Society for Medical Oncology (ESMO) Immuno-Oncology Congress 2025 took place in London from 10 to 12 December 2025. The meeting provided an overview of fundamental concepts in immuno-onco...

He and colleagues develop a METTL3-based RNA base-editing screening strategy to identify functional N6-methyladenosine (m6A) sites that are important for prostate cancer cells and validate the role of...

Tan and colleagues discuss recent advances in spatial omics and computational models that inform the classification and clinical relevance of cellular neighborhoods in cancer.

Join us at the Keystone Symposia on Spotlight on the Cancer Cell: Intrinsic Properties and Vulnerabilities for Therapeutics, January 2026, in Cary, with field leaders!

Yabut and Drucker discuss clinical and preclinical evidence about the potential roles of GLP-1 medicines on cancer incidence, development and therapy and speculate about their mechanism on cancer cell...

Chen et al. report the design and characterization of a systemically injectable oncolytic virus with tumor-targeting and low-immunogenic properties, engineered to induce tumor cell pyroptosis under lo...