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Reposted by Centre for Evolution and Cancer (CEC)

Trevor Graham @trevorgraham.bsky.social · 02/05/2025

Of course, the original idea of Adaptive Therapy was from the visionary Robert (Bob) Gatenby at @moffittnews.bsky.social. His seminal paper: aacrjournals.org/cancerres/ar... & lots of work since, with the epicentre being @sandyanderson.bsky.social's Centre at @moffittnews.bsky.social

aacrjournals.org

Adaptive Therapy

Abstract. A number of successful systemic therapies are available for treatment of disseminated cancers. However, tumor response is often transient, and therapy frequently fails due to emergence of re...

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Reposted by Centre for Evolution and Cancer (CEC)

Trevor Graham @trevorgraham.bsky.social · 02/05/2025

In other words - remarkably - it could be that less drug, less often leads to better outcomes for some patients with ovarian cancer. We eagerly await the clinical trial results - they will be definitive.

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Reposted by Centre for Evolution and Cancer (CEC)

Trevor Graham @trevorgraham.bsky.social · 02/05/2025

With the brilliant @mlockley.bsky.social we've been exploring chemo resistance evolution in ovarian cancer. We find resistance has a fitness cost which means resistant cells are outcompeted by sensitive cells when treatment is stopped. aacrjournals.org/cancerres/ar... @icr.ac.uk @qmbci.bsky.social

aacrjournals.org

Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control

Abstract. Drug resistance results in poor outcomes for cancer patients. Adaptive therapy is a potential strategy to address drug resistance that exploits competitive interactions between sensitive and...

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Reposted by Centre for Evolution and Cancer (CEC)

George Seed @seedgeorge.bsky.social · 05/12/2024

Delighted that a major project of my post-doctoral fellowship in the de Bono lab has been published. A really interesting story, featuring the likes of @icrlordlab.bsky.social @boragurel.bsky.social among many others at @icrlondon.bsky.social and elsewhere.

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Centre for Evolution and Cancer (CEC) @cec-icr.bsky.social · 22/11/2024

Frequent evolution of BRCA2 reversion mutations during PARPi treatment in prostate cancer

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Centre for Evolution and Cancer (CEC) @cec-icr.bsky.social · 21/11/2024

Welcome to #bsky @alejandrapcelab.bsky.social ! Alejandra Bruna leads the paediatric cancer evolution (PCE) lab here in our @cec-icr.bsky.social. Focusing on dissecting the role of phenotypic plasticity in childhood cancer evolution and therapy response.

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