Background Cell state-specific gene expression programs emerge from the interplay between cis-regulatory elements (CREs), such as enhancers, and transcription factors (TFs). Massively parallel reporte...

Lewis et al. identify lamin B receptor (LBR) and lamina-associated polypeptide 2 (LAP2) as major factors that tether heterochromatin to the envelope. Deletion of these proteins causes changes in 3D ge...

The ability of cancer cells to change their identity makes tumors such as glioblastoma particularly aggressive and resistant to treatment. Moritz Mall, of the German Cancer Research Center (DKFZ) and ...

Die Fähigkeit von Krebszellen, ihre Identität zu wechseln, macht Tumoren wie das Glioblastom besonders aggressiv und therapieresistent. Moritz Mall, Deutsches Krebsforschungszentrum (DKFZ) und Hector ...

With its Proof of Concept (PoC) grants, the European Research Council (ERC) supports scientists in further developing the economic potential of their research results. Two scientists from the German C...

A key molecular mechanism drives the growth of liver cell cancer while simultaneously suppressing the body's immune response to the tumor. This has now been published in the journal Nature by a team l...

Since their discovery in 2004, the grid cells in the brain, which are important for our orientation, have been regarded as a kind of “GPS in the head.” However, scientists at the German Cancer Researc...

Glioblastoma (GB) is one of the most lethal human cancers, marked by profound intratumoral heterogeneity and near-universal treatment resistance. Cellular plasticity, the capacity of cancer cells to t...

YouTube video by Tierversuche verstehen

On Friday, scientists will leave their labs to protest cuts to research in Chicago and across the country.

YouTube video by Deutsches Krebsforschungszentrum (DKFZ)