In this issue of Cancer Cell, García-Gómez et al. show that brain-seeding cancer cells exploit an MXD4-dependent proliferative pause that enables survival under stress before metastatic outgrowth. By ...

Di Blasio et al. use murine skeletal progenitors to bioengineer extramedullary bone, showing that metastatic breast cancer cells can enter dormancy, characterized by quiescence and low proliferation. ...

Recurrence and metastasis remain major causes of cancer mortality, sustained by therapy-resistant micrometastatic cells. Bone is a frequent site of breast-cancer relapse, yet the cues that reawaken di...

Nature reveals the studies that are mentioned most often in patent filings — and why.

Cell migration requires the precise coordination of signaling pathways that regulate cytoskeletal dynamics and adhesion turnover. Rho GTPase–activating proteins (RhoGAPs) play critical roles in shapin...

Nature Reviews Cancer publishes a dynamic and accessible mix of Reviews, Perspectives, Progress and Highlight articles on the most important primary research ...

Metastasis-associated oncofetal cell states emerge at the earliest stages of colorectal cancer and spatial profiling shows stereotypic patterning of fibroblast subtypes resembling normal tissue archit...

Cancer Dormancy Institute, Montefiore Einstein Comprehensive Cancer Center (MECCC). Non-institutional website for the laboratory headed by Dr. Samarth Hegde, Department of Developmental and Molecular ...

As budding yeast enter starvation-induced quiescence, respiration is required to properly modulate the biophysics of the cytoplasm and ensure cell survival

Geng et al. report that quiescent persister tumor cells persisting after neoadjuvant chemotherapy can restrain CD8+ T cell-mediated cytotoxicity via CD96, thereby contributing to colorectal cancer rec...

Multimodal machine learning reveals that tumour microenvironments can be decomposed into spatially organized multicellular ecosystems, termed spatial ecotypes, that can be accessed non-invasively via ...

DNA-sequencing data from primary tumours and paired metastases from participants in the TRACERx lung study and PEACE autopsy programme are used to analyse the metastatic diversity of advanced non-smal...

An unbiased niche-labeling method, SAMENT, maps cellular and molecular features of metastatic niches and highlights the role of ERα⁺ niche macrophages in preventing T cell infiltration, thereby promot...

This Review synthesizes emerging insights into how microenvironmental cues, epigenetic programmes and immune interactions govern disseminated cancer cell dormancy and outlines how advances in dormancy...

The heart rarely develops cancer, and, at the same time, it lacks regenerative capacity, as cardiomyocytes stop proliferating after birth. This suggests that mechanisms limiting cardiac regeneration m...

Defense-associated reverse transcriptases (DRTs) are widespread bacterial anti-phage systems that use unconventional mechanisms of polynucleotide synthesis. We show that DRT3, which comprises two dist...

This Review revisits tumour initiation and promotion in light of clonal diversity and the presence of cancer driver mutations in normal tissues, aiming to understand mechanisms that enable environment...

Bruce Alberts is honored for fundamental discoveries in DNA replication and protein biochemistry; for visionary leadership in directing national and international scientific organizations to better people’s lives; and for passionate dedication to improving education in science and mathematics.

PRRX1 is an epithelial– mesenchymal transition-linked transcription factor. Here, the authors discover that intermediate PRRX1 levels primes cancer cell for high invasion and metastatic fitness, where...

Mouse models demonstrate that vagal sensory neurons transmit signals from lung adenocarcinoma to the brain, increasing sympathetic efferent activity in the tumour microenvironment and thereb...

Many cancers are linked to two modifiable habits: tobacco smoking and alcohol consumption.

In this randomized phase 3 trial, patients with treatment-naive stage III–IV nonsmall cell lung cancer who received sintilimab or pembrolizumab in combination with chemotherapy early in the day (befor...

Five-year survival data and biomarker analysis of the PRADO extension cohort of the phase 2 OpACIN-neo trial, in which patients with high-risk stage III melanoma received neoadjuvant ipilimumab and ni...

Dormant metastases can lead to tumor relapse after many years by successfully escaping immune surveillance. A new study identifies an atypical epithelial-to-mesenchymal transition state that presents ...

Scientists have transformed enigmatic cell structures, called vaults, into storage units for messenger-RNA molecules made in the past.

Tell New York Governor Hochul and your state legislators to support including the Empire Biomedical Research Institute in the 2027 Executive Budget. This is an urgent matter relating to funding life-s...