Mammalian embryos see a substantial increase in available oxygen once the placenta forms. This increase in oxygen exposure serves as a trigger for initiating the development of the hindlimb, thus cont...

An updated phylogeny of bats is presented, based on new genome assemblies and many ancient fossils and including all known bat families.

A key requirement to address fundamental questions in developmental biology is the ability to visualise and manipulate endogenous signalling proteins in vivo. Here we generate such an enabling experim...

I have written before about how two conceptual frameworks have shaped our thinking about cell fate, Waddington's epigenetic landscape and Davidson's gene...

Successful regeneration recovers lost tissues to their original form. Here, we investigate how proliferation of bone-forming osteoblasts is timely regulated to control tissue size during zebrafish sca...

Animal cells extensively remodel their cytoskeleton during differentiation and can notably switch between two major motility modes: flagellum-based swimming and actin-based crawling. We previously sho...

Understanding how cells establish spatial organization within tissues is a fundamental question in life sciences. While modern three-dimensional fluorescence microscopy captures large-volume tissue ar...

High-dimensional data are visualized through representation on tree structures.

Adult intestinal size plasticity is driven not only by epithelial stem cells but also by remodeling of the surrounding visceral musculature. Sex- and reproduction-dependent muscle remodeling controls ...

Gastrulation is the morphogenetic process by which the single-layered pluripotent epiblast is reorganised into the three germ layers and the basic bod…

Epithelial cell extrusion in a sea anemone shares key hallmarks with bilaterians and is dynamically regulated by nutritional status. During starvation-induced body shrinkage, extrusion likely contribu...

Proportional organ growth requires tissue-level control of cell behavior. Yet the cues that adapt growth rates, especially after organ injury, remain unclear. Here, we uncover that developing organs a...

This study introduces iChIP2, a low-input chromatin immunoprecipitation followed by sequencing method that profiles histone post-translational modifications (hPTMs) simultaneously across diverse eukar...

Venue: Lecture hallCentre for Organismal Studies – Heidelberg UniversityIm Neuenheimer Feld 230

The Helsen lab at the University of Geneva explores how centromeres and chromosomes evolve, diversify, and function across eukaryotes. Discover our latest publications, research team, and open positio...

ALT: Callipterus Cichlid Collecting Shell

How cells clean house across the eukaryotic tree of life. Autophagy & cellular quality control at Heidelberg University.

During gastrulation, embryonic epithelia undergo large-scale remodelling to internalise the mesoderm. Whether the cellular mechanisms underlying these tissue deformations are conserved across species ...

The spatial patterning of mammalian hair follicle precursors in embryonic skin is most commonly studied in the laboratory mouse (Mus musculus), whe...

Developing embryos have a striking ability to buffer external and internal perturbations. A key example of this phenomenon across developing systems is successful organ formation even after substantia...

Neuronal migration is essential for establishing functional tissue architecture in the developing central nervous system. While cell-intrinsic mechanisms driving neuronal movement have been identified...

During embryogenesis, cell types arise in a predictable order because developmental regulators act sequentially. But how evolutionary changes in morphogenesis reshape the signaling environments that a...

Temperature shapes reproductive strategies across animals, yet how individuals switch between sexual and asexual reproduction remains unknown. We establish the planarian Phagocata morgani as a model f...

Rigidity transitions govern tissue organization in ways reminiscent of inert materials. Yet, living tissues are composed of active units with autonomous timing mechanisms, raising the question whether...

DNA-barcoded antibodies are central to a broad range of spatial and dissociative assays and applications, including multiplexed imaging, single-cell profiling, and proximity detection. Direct modifica...

AbstractMotivation. Incomplete gene models negatively impact single-cell gene expression quantification. This is particularly true in non-model species whe

A new study finds that hundreds of lives have been saved since school-age girls were offered the HPV jab in 2008.

This June, we celebrate Pride by discussing with Felix Gunawan, assistant professor at the University of Toronto and co-affiliate group leader at the University of Münster, about his personal and acad...