Mammalian embryos see a substantial increase in available oxygen once the placenta forms. This increase in oxygen exposure serves as a trigger for initiating the development of the hindlimb, thus cont...

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We seek a highly motivated Postdoctoral Research Associate to join the laboratory of Professor Kathy Niakan. We are based in the Loke Centre for Trophoblast Research (LCTR), in the Department of Physi...

Why mammals cannot regenerate limbs like amphibians do presents a long-standing puzzle in biology. To uncover the underlying differences, we compared amputation responses of embryonic mouse (Mus musculus) and Xenopus laevis tadpole limbs. Lowering ...

We study how development measures time and how timing matters in development, evolution and ageing.

We study how development measures time and how timing matters in development, evolution and ageing.

Lystrosaurus fossil reveals how some early ancestors of mammals may have reproduced in the wake of the Great Dying

Tissue regeneration is rare in mammals, but the digit tip can regrow after amputation, whereas injuries beyond the nail do not. How the microenvironment drives divergent outcomes remains unclear. In this study, we found that the extracellular matrix (ECM)...

Flying insect respiratory systems suggest abundant oxygen can’t explain ancient gigantism

There is a crucial need for strategies that stimulate repair in the adult brain. The neonatal mouse cerebellum can regenerate via the adaptive reprogramming of nestin (Nes)-expressing progenitors (NEP...

Heterochrony, or the alteration of developmental timing, is an important mechanism of evolutionary change. Avian species display synchronized growth of the forelimbs and hindlimbs, while mammalian spe...

Join us at the EMBO Workshop "EvoDevoTempo – Developmental Timing Across Species: From Mechanisms to Evolutionary Insights". Topics will include

Launched in 2020, Development presents... is a monthly Zoom webinar series covering the fields of developmental biology, stem cells and regeneration. Each

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Growth deceleration is a universal feature of growth during development: most organs and tissues slow down their growth rate much before growth termination. Using transcriptomics analysis, we show tha...