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Félix Ramos-León

@felixrl.bsky.social
1.4K followers 920 following 98 posts

Postdoctoral fellow at NIH studying cell biology of coccoid bacteria. Views my own. He/him/Él 🏳️‍🌈

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Reposted by Félix Ramos-León
Tanmay Bharat @tbharat-lab.bsky.social · 17h
Diverse S-layer anchoring mechanisms create an epiplasmic space in prokaryotic cell envelopes. Our review with @bupbuse.bsky.social and @vikramalva.bsky.social discussing a cellular compartment created by the S-layer out in Current Opinion in Microbiology. www.sciencedirect.com/science/arti...
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Reposted by Félix Ramos-León
Wiep Klaas Smits (ExpBac/CMAT) @smitslab.bsky.social · 29/09/2026
Flagellar toxicity: Flagellar synthesis is lytic for Bacillus subtilis in the absence of PBP1 | PNAS www.pnas.org/doi/10.1073/...
pnas.org
Flagellar toxicity: Flagellar synthesis is lytic for Bacillus subtilis in the absence of PBP1 | PNAS
Flagella are large transenvelope nanomachines but how they transit the peptidoglycan in gram-positive bacteria is poorly understood. A recent model...
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Reposted by Félix Ramos-León
Jörg Stülke @joergstuelke.bsky.social · 26/09/2026
Identification of a novel RNA-modifying enzyme! RlmS! #SubtiWiki www.pnas.org/doi/10.1073/...
pnas.org
Activity-based profiling of bacterial RNA-modifying enzymes reveals species-specific 5-methyluridine modification in Bacillus subtilis 23S rRNA | PNAS
RNA modifications play an important role in biological processes. Mapping the diversity of RNA chemistry and studying the biological function of in...
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Reposted by Félix Ramos-León
Jan-Ulrik Dahl (Dahl lab, ISU) @janulrikdahl.bsky.social · 25/09/2026
Join us and become my colleague! The School of Biological Sciences is opening the search for an Assistant Professor in the field of Host-Microbe Interactions with the targeted start date of Fall 2027. Please reach out to me with any questions you have: jobsearch.illinoisstate.edu/jobs/assista...
jobsearch.illinoisstate.edu
ASSISTANT PROFESSOR IN HOST-MICROBE INTERACTIONS (IMMUNOLOGY, MICROBIOLOGY) - Normal, Illinois, Illinois, United States
Title: ASSISTANT PROFESSOR IN HOST-MICROBE INTERACTIONS (IMMUNOLOGY, MICROBIOLOGY)Employee Classification: Asst ProfessorDivision Name: Academic AffairsCollege/Unit: College of Arts and SciencesDepart...
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Reposted by Félix Ramos-León
Erin Hotchkiss @fluvialbenthos.bsky.social · 24/09/2026
We (Biological Sciences at Virginia Tech) are #hiring TWO tenure-track Molecular Microbiology professors! Review of applications starts 1 Nov. I'm happy to answer questions about the department, VT, life in Blacksburg, etc.! More info / to apply: jobs.apply.vt.edu/jobs/assista... 🧪👩‍🔬🦠 #academicjobs
jobs.apply.vt.edu
Assistant/Associate Professor - Blacksburg, Virginia, United States
Job Description The Department of Biological Sciences in the College of Science at Virginia Tech seeks applicants for two (2) tenure-track research and teaching positions at the Assistant/Associate ...
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Reposted by Félix Ramos-León
bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 24/09/2026
A microbiome-derived metabolite from Staphylococcus epidermidis inhibits Staphylococcus aureus biofilm formation and virulence www.biorxiv.org/content/10.64898/20…
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Reposted by Félix Ramos-León
John Helmann @johnhelmann.bsky.social · 23/09/2026
Bacillus subtilis biofilm formation is strongly stimulated by manganese. New results from Sachla et al. show that a Mn export protein (MeeY) and YybP are important for biofilm regulation, maturation, and proper matrix metalation 🎉🧪🦠 #Microsky www.nature.com/articles/s41...
nature.com
MeeY and YybP, two proteins regulated by manganese-sensing riboswitches, are required for Bacillus subtilis biofilm formation - npj Biofilms and Microbiomes
npj Biofilms and Microbiomes - MeeY and YybP, two proteins regulated by manganese-sensing riboswitches, are required for Bacillus subtilis biofilm formation
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Reposted by Félix Ramos-León
Simonetta Gribaldo @sgribaldo.bsky.social · 23/09/2026
Interested in #archaea, #methane, #cell-envelopes? New paper out @nature.com ! We discovered an enzyme that specifically cleaves the cell wall of methanogens, revealing a new chemical structure of archaeal peptidoglycan, 50 yrs after its first description www.nature.com/articles/s41... #MicroSky 🧵👇
nature.com
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Reposted by Félix Ramos-León
Paul Hoskisson 🧫 🦠🐸 @paulhoskisson.bsky.social · 22/09/2026
This is very cool @kelleygallagher.bsky.social et al Regulatory divergence and functional diversification of a c-di-GMP-controlled sigma factor in Actinomycetota doi.org/10.1128/msys...
doi.org
Regulatory divergence and functional diversification of a c-di-GMP-controlled sigma factor in Actinomycetota | mSystems
Mounting global responses to dynamic environmental conditions is a crucial function that bacterial cells must perform. Global regulatory networks are most often studied in individual species, however,...
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Reposted by Félix Ramos-León
bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 20/09/2026
A cis-encoded RNA interaction controls sub-operonic spoVG expression in Staphylococcus aureus www.biorxiv.org/content/10.64898/20…
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Reposted by Félix Ramos-León
Anthony Vecchiarelli @cellforganized.bsky.social · 19/09/2026
Applications are now being accepted for the 2027 Bacterial Cell Biology & Development GRC, June 6–11! GRS will be on June 5-6, 2027 We’ll likely be oversubscribed, so please apply early!
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Reposted by Félix Ramos-León
bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 18/09/2026
A two-step model of FtsZ-ring disassembly in Bacillus subtilis www.biorxiv.org/content/10.64898/20…
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Reposted by Félix Ramos-León
Kumaran Ramamurthi @ramamurthilab.bsky.social · 18/09/2026
Folks have known for years that adding magnesium to media rescues the lethality of deleting many 'essential' genes, but why? @eswaralab.bsky.social and @subtisilly.bsky.social say that free iron builds up in these mutants. Mg2+ mitigates this by redirecting metabolism towards limiting ROS production
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Reposted by Félix Ramos-León
Lzvolk @lzvolk.bsky.social · 17/09/2026
This is sooo cool! #Asgards !! Including micrographs/vids. Made my day.........
nature.com
These bizarre, much-coveted microbes are revealing the origins of complex life
Researchers are racing to culture a menagerie of exotic organisms and finding lots of surprises along the way.
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Reposted by Félix Ramos-León
Evgenii Protasov @evgenii-protasov.bsky.social · 17/09/2026
Structural diversity and functional versatility in Gram-positive S-layers #microbiology #bacteria #MicroSky www.sciencedirect.com/science/arti...
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Reposted by Félix Ramos-León
Kumaran Ramamurthi @ramamurthilab.bsky.social · 15/09/2026
How do proteins localize in bacteria? Usually by binding to a prelocalized protein-but how does that protein localize? @vanipande.bsky.social found a #Bacillus subtilis protein that localizes via a lipid cue,undecaprenyl phosphate,that guides it to sites of PG synthesis www.pnas.org/doi/10.1073/...
pnas.org
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
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Reposted by Félix Ramos-León
Kevin England @kevinengland.bsky.social · 13/09/2026
Our paper (and my first first-author) is out! The alarmone pGpp inhibits translation through GTP depletion academic.oup.com/nar/article/... 🦠🚨🤠 @narjournal.bsky.social
academic.oup.com
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Reposted by Félix Ramos-León
Frances Yap @ribo1214.bsky.social · 13/09/2026
Mycobacterial rRNA methyltransferase GidB modulates discrimination of mischarged tRNA doi.org/10.7554/eLif... #MicroSky #RNASky 🧪
doi.org
Ribosomal RNA methylation by GidB modulates discrimination of mischarged tRNA
The ribosomal rRNA methyltransferase GidB is involved in the discrimination of mischarged tRNAs in mycobacteria.
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Reposted by Félix Ramos-León
Zeynep Baharoglu @zeynepbaharoglu.bsky.social · 12/09/2026
Pyridoxal-phosphate-dependent biosynthesis of aminovaleramide by AvaS in tRNA 🦠💫 Discovery of AvaS, the enzyme cqtqlyzing ava2C modificqtion on tRNA-ile www.nature.com/articles/s41...
nature.com
Pyridoxal-phosphate-dependent biosynthesis of aminovaleramide by AvaS in tRNA - Nature Chemical Biology
Sun, Wu et al. identify AvaS as a pyridoxal-phosphate-dependent RNA-modifying enzyme, producing the tRNA modification ava2C from k2C in bacteria and plants and linking RNA chemistry to translational r...
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Reposted by Félix Ramos-León
Diversify Microbiology @diversifymicro.bsky.social · 11/09/2026
UNC Greensboro Department of Biology is hiring for three positions this year including one in microbiology! spartantalent.uncg.edu/postings/35918
spartantalent.uncg.edu
Assistant Professor Microbiology
The Department of Biology at UNC Greensboro (UNCG) seeks an individual with a strong record of accomplishment in microbiology broadly defined for a tenure-track faculty position at the rank of Assista...
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Reposted by Félix Ramos-León
Florian Mayer @florianmayer.bsky.social · 11/09/2026
Excited to share our preprint on Ignicoccus cell divison: only the inner membrane divides, progeny cells accumulate in cell clusters and pop-out! www.biorxiv.org/content/10.6... Great work with the labs: @buzzbaum.bsky.social @curiousdina.bsky.social @anja1.bsky.social @tbharat-lab.bsky.social
biorxiv.org
The life cycle of an archaeon with multiple membranes
Many prokaryotes are diderms. They divide using an FtsZ division ring to simultaneously constrict physically coupled inner and outer membranes to form daughter cells with two membranes. Currently, onl...
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Reposted by Félix Ramos-León
Paul Hoskisson 🧫 🦠🐸 @paulhoskisson.bsky.social · 11/09/2026
Really important from @ellinoralseth.bsky.social & @brownlab.bsky.social - a framework for defense as an evolved adaptation, in a world where ‘defense’ & ‘immune’ are often used to mean anti-infection The bacterial immune system: identifying evolved defense adaptations www.cell.com/trends/micro...
cell.com
The bacterial immune system: identifying evolved defense adaptations
Recent years have witnessed a rapid expansion in bacterial defense mechanisms. Alongside established defenses against molecular parasites, hundreds of novel mechanisms are being described annually, co...
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Reposted by Félix Ramos-León
Staph papers @staph-papers.bsky.social · 10/09/2026
Acidic and alkaline conditions enhance Staphylococcus aureus α-toxin pore formation and cytotoxicity
t.co
Acidic and alkaline conditions enhance Staphylococcus aureus α-toxin pore formation and cytotoxicity - PubMed
Staphylococcus aureus α-toxin (AT) is a potent pore-forming toxin that causes cell damage during infection. The structure and activity of AT have been studied extensively, but the environmental factors...
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Reposted by Félix Ramos-León
bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 10/09/2026
Oral Actinobacteria sense and defend against parasitic epibionts www.biorxiv.org/content/10.64898/20…
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Reposted by Félix Ramos-León
John Helmann @johnhelmann.bsky.social · 09/09/2026
Most cells require carbonic anhydrase and/or bicarbonate import to sustain pools of soluble inorganic carbon (SIC=CO2+HCO3-). Here, we identify proteins required for SIC homeostasis in Bacillus subtilis and identify a mutation that bypasses their requirement. www.biorxiv.org/content/10.6...
biorxiv.org
Physiological Roles of Carbonic Anhydrases and an MpsAB-like Bicarbonate Transporter in Bacillus subtilis
Carbonic anhydrase (E.C. 4.2.1.1) is an enzyme that catalyzes the reversible hydration of CO2 to carbonic acid (H2CO3), which dissociates to bicarbonate (HCO3-) at intracellular pH. Copious amounts of...
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Reposted by Félix Ramos-León
Cyanotrans @cyanotrans.bsky.social · 09/09/2026
Genetic access to the obligate cyanobacterial endosymbiont Nostoc azollae within the Azolla fern host academic.oup.com/ismecommun/a...
academic.oup.com
Genetic access to the obligate cyanobacterial endosymbiont Nostoc azollae within the Azolla fern host
Abstract. Eukaryote-associated microbes are ubiquitous, but their essential roles in the development and ecology of their host is yet to be fully understoo
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Reposted by Félix Ramos-León
bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 09/09/2026
Cyclic di-AMP signalling affects cell division and penicillin susceptibility in Streptococcus pneumoniae. www.biorxiv.org/content/10.64898/20…
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Reposted by Félix Ramos-León
Molecular Microbiology @molmicrounihoh.bsky.social · 07/09/2026
Colibactin produced by a honeybee gut symbiont mediates pathogen defence: www.nature.com/articles/s41... #bee #honey @natmicrobiol.nature.com
nature.com
Colibactin produced by a honeybee gut symbiont mediates pathogen defence - Nature Microbiology
A colibactin-producing symbiont in honeybee guts defends against opportunistic pathogens and confers protection.
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Reposted by Félix Ramos-León
Evgenii Protasov @evgenii-protasov.bsky.social · 07/09/2026
Defining the order of assembly of the Clostridioides difficile divisome complex #microbiology #Clostridia #MicroSky @asm.org journals.asm.org/doi/10.1128/...
journals.asm.org
Defining the order of assembly of the Clostridioides difficile divisome complex | Journal of Bacteriology
Bacterial cell division has been extensively studied in model systems, but little is known about how this essential process occurs in the clinically important pathogen Clostridioides difficile. Studie...
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Reposted by Félix Ramos-León
Sarah Svensson @campy-bara.bsky.social · 19/11/2025
Sharing the link to our updated Vibrio preprint, where we compare and contrast Ecospecies with other genetic structures, and using the opportunity to fix typos and update some bluesky handles! with @danielfalush.bsky.social @whqqq.bsky.social @yjchao.bsky.social @chaooo.bsky.social
biorxiv.org
Evolution of hunt, kill, devour in a Vibrio ecospecies
Bacterial ecospecies are a recently recognized genetic structure that is hypothesized to arise by complex adaptation to a new niche. Coadaptation within the “Molassodon” ecospecies of Vibrio parahaemo...
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Max Jordan @maxljordan.bsky.social · 04/09/2026
Really excited to share our new manuscript on how the #NLR protein #AfsR regulates #Streptomyces antibiotic production - and how we can use its similarity to plant NLR immune receptors to enhance this production! 📄🧵 (1/17) @johninnescentre.bsky.social www.biorxiv.org/content/10.6...
biorxiv.org
A conserved NLR activation switch governs global transcriptional control of antibiotic biosynthesis in Streptomyces
Nucleotide-binding and oligomerization domain-like receptors (NLRs) are conserved molecular switches that regulate innate immunity across diverse domains of life. While best known for their roles in i...
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Reposted by Félix Ramos-León
Prahathees Eswara @eswaralab.bsky.social · 02/09/2026
Thrilled to share this insightful work of Asher King @subtisilly.bsky.social and Pilar Horigian @pilarhorigian.bsky.social! #ProudPI #MicroSky #AMR #SubtiWiki In this work, we reveal the *magic* behind the protective effects of magnesium in Bacillus subtilis. Read Asher's 🧵 below for more details.
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Reposted by Félix Ramos-León
Jan-Willem Veening @veeninglab.com · 28/08/2026
I hadn't thought about the problem of division site selection in a long time. Really cool to see these new studies shining fresh light on such a fundamental question. Especially checkout this work by @aducret.bsky.social & Christophe Grangeasse: doi.org/10.1038/s415...
doi.org
Local peptidoglycan composition defines division site selection in Streptococcus pneumoniae - Nature Microbiology
Sequential peptidoglycan carboxylase activity of DacA and DacB generates a local peptidoglycan signature that recruits MapZ and establishes the division site at the Streptococcus pneumoniae cell equat...
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Omar El-Halfawy @omarel-halfawy.bsky.social · 30/08/2026
Happy to share our recent paper at @pubs.acs.org's #ACSInfectDis studying the antibiotic responses of MRSA, one of the most common pathogens in paediatric patients with Cystic Fibrosis (CF), in CF artificial sputum compared to standard lab test conditions. pubs.acs.org/aidcbc/artic...
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Seth Dickey @dickeylab.bsky.social · 28/08/2026
I’m thrilled to share our newest study in which @thesbhowmick.bsky.social y.social developed and applied a genome-wide platform to uncover genetic interactions in Staphylococcus aureus and MRSA. www.biorxiv.org/content/10.6... 1/10
biorxiv.org
A genome-wide genetic interaction platform for MRSA reveals connections between cell division and the cell envelope
The bacterial cell cycle is an ensemble of integrated pathways that coordinates cell growth and division. Although these pathways contain a suite of promising antimicrobial targets, their functional o...
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Reposted by Félix Ramos-León
Anthony Vecchiarelli @cellforganized.bsky.social · 26/08/2026
My MCDB Dept is hiring, again! Assistant Professor Faculty Search. Please Repost! Applications Due Oct 1st We welcome applications from all areas of cellular/molecular biology in prokaryotes, plants, and animals. More information can be found HERE: jobs.sciencecareers.org/job/679540/a...
jobs.sciencecareers.org
Assistant Professor - Ann Arbor, Michigan job with University of Michigan - Molecular, Cellular and Developmental Biology | 679540
UNIVERSITY OF MICHIGAN FACULTY POSITION IN CELL & MOLECULAR BIOLOGY AND RELATED FIELDS   The Department of Molecular, Cellular, and Developmental B...
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Carballido-López's lab @carballido-lab.bsky.social · 25/08/2026
New preprint from the lab (link below), and first preprint from Matteo Gerard, who will soon be a doctor (and looking for a post-doc, just saying). Toolbox for fluorescent labelling of Pseudomonas aeruginosa across scales: from single cells to bacterial communities and host infection models.
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Susan Schlimpert @s-lab.bsky.social · 25/08/2026
It is happening, and registration is open for the EMBO Workshop: Bacterial and archaeal cell division: diverse mechanisms and models. 20–23 April 2027 | Barga, Italy. Come and join us @awehenkel.bsky.social, @seamusholden.bsky.social, @s-lab.bsky.social ! Deadline: Jan 6, 2027. #Bacdiv27
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Reposted by Félix Ramos-León
EMBO @embo.org · 24/08/2026
Sign up now for the EMBO Workshop "Bacterial and archaeal #CellDivision: Diverse mechanisms and models" in Barga (Lucca), Italy, 20–23 April 2027. Deadline: 6 January 2027 meetings.embo.org/event/27-cell-div… #EMBObacDiv27 #genetics #biochemistry #StructuralBiology #EMBOevents 🧪
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Reposted by Félix Ramos-León
Adrià Sogues @adriasogues.bsky.social · 24/08/2026
My latest publication with the @remaut-lab.bsky.social is out! We wrote a review about Structure and Function of S-layers in G+ bacteria. Enjoy the read! :) www.sciencedirect.com/science/arti...
sciencedirect.com
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Jonathon L. Baker, Ph.D. @jonbakerlab.bsky.social · 23/08/2026
New publication in collaboration with the Pfeifer Lab at OHSU. We identified commercially available drugs capable of inhibiting GtfC, a critical enzyme for biofilm initiation and cohesion by the pathogen, Streptococcus mutans. #microbiology #dentistry www.nature.com/articles/s41...
nature.com
Drug repurposing for glucosyltransferase inhibition for targeted oral biofilm disruption - npj Biofilms and Microbiomes
npj Biofilms and Microbiomes - Drug repurposing for glucosyltransferase inhibition for targeted oral biofilm disruption
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Reposted by Félix Ramos-León
Kumaran Ramamurthi @ramamurthilab.bsky.social · 20/08/2026
@felixrl.bsky.social told us previously *how* #Staph aureus does orthogonal cell division. In his latest paper he tells us *why*: to arrange cell surface proteins required to form staphylococcal abscess colonies. (Videos S1-S2 are amazing!). 🤯 www.cell.com/cell-reports...
cell.com
Orthogonal cell division mediated by PcdA organizes surface virulence factors to drive staphylococcal abscess community formation
Staphylococcus aureus divides along sequential orthogonal planes, but the function of this geometry has remained unclear. Ramos-León et al. show that orthogonal division promotes uniform deployment of...
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The EMBO Journal @embojournal.org · 19/08/2026
Multicellular cyanobacteria build long filaments in which connected neighboring cells exchange molecules trough so-called septal junctions @selimlab.bsky.social & collaborators show a key role of calcium signaling and the calcium-binding protein CSE in this process link.springer.com/article/10.1...
link.springer.com
The calcium-binding protein CSE links Ca2+ signaling with cell-cell communication in cyanobacteria - The EMBO Journal
Multicellular cyanobacteria have evolved sophisticated cell–cell communication machinery to exchange, synchronize, and coordinate the efforts of individual cells. Analogous to gap junctions that have ...
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Tominaga K. (tomiken) @pacyc184.bsky.social · 19/08/2026
Bacterial small regulatory RNAs | Nature Reviews Microbiology
nature.com
Bacterial small regulatory RNAs - Nature Reviews Microbiology
In this Review, Papenfort discusses established and emerging aspects of bacterial small RNAs (sRNAs), their molecular mechanisms and regulatory principles, and the global impact of sRNAs on cellular gene expression profiles.
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Zeynep Baharoglu @zeynepbaharoglu.bsky.social · 19/08/2026
A revised genome annotation of the model cyanobacterium Synechocystis based on start and stop codon-enriched ribosome profiling and proteogenomics www.biorxiv.org/content/10.6...
biorxiv.org
https://www.biorxiv.org/content/10.64898/2025.12.20.695498v3
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Félix Ramos-León @felixrl.bsky.social · 18/08/2026
Excited to share my latest work in the @ramamurthilab.bsky.social, now in @cp-cellreports.bsky.social! We show that division geometry organizes surface adhesins in S. aureus and enables the formation of abscess communities that protect bacteria from immune cells. www.cell.com/cell-reports...
cell.com
Orthogonal cell division mediated by PcdA organizes surface virulence factors to drive staphylococcal abscess community formation
Staphylococcus aureus divides along sequential orthogonal planes, but the function of this geometry has remained unclear. Ramos-León et al. show that orthogonal division promotes uniform deployment of...
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Reposted by Félix Ramos-León
Anthony Vecchiarelli @cellforganized.bsky.social · 18/08/2026
www.pnas.org/doi/10.1073/... A peripheral carboxysome component regulates cyanobacterial glycogen deposition! Paper from our former Postdoc Joshua MacCready and the Ducat Lab!
pnas.org
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
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Reposted by Félix Ramos-León
anna brogan @apbrogan.bsky.social · 18/08/2026
This is now published! For those interested in microbial mechanotransduction: www.cell.com/current-biol...
cell.com
Microbial GAIN domains undergo autoproteolysis and enable release of diverse cell-surface-associated proteins
Brogan and Rudner report the identification of a microbial autoproteolytic domain that is structurally homologous to the GAIN domain of eukaryotic adhesion GPCRs. Rather than participating in transmem...
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Reposted by Félix Ramos-León
Nature Reviews Disease Primers @natrevdiseaseprimers.nature.com · 18/08/2026
This Figure details the pathophysiology of MRSA infection within the bloodstream, skin and soft tissue, lungs and bone. dlvr.it/TV3sFG
This Figure shows the pathophysiology of MRSA infections.
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Nature Microbiology @natmicrobiol.nature.com · 17/08/2026
Out Now! Quinone-transporting filaments expand bioenergetic capacity in Gram-positive Bacillota #MicroSky
go.nature.com
Quinone-transporting filaments expand bioenergetic capacity in Gram-positive Bacillota
Nature Microbiology, Published online: 17 August 2026; doi:10.1038/s41564-026-02450-zBacillus subtilis Ncp and NADH dehydrogenase form tube-like filaments with phospholipid-lined chambers that associate with quinones, which can expand bioenergetic capacity and support respiratory electron transfer.
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