RNA modifications play an important role in biological processes. Mapping the diversity of RNA chemistry and studying the biological function of in...

I grew up in a small town, Wauseon, in the northwest corner of Ohio. Although I enjoyed science and math classes in high school, a career in research and academia never crossed my mind. I worked for s...

Phosphorothioates, stereospecific modifications of the RNA phosphate backbone in anaerobic archaea, expand the epitranscriptome beyond nucleobases and ribose sugars. Installed by Esti enzymes at conse...

The ribosomal rRNA methyltransferase GidB is involved in the discrimination of mischarged tRNAs in mycobacteria.

Ribosomal RNA (rRNA) transcription rates vary during development, and their dysregulation is linked to diseases such as cancer and ribosomopathies. Owing to their high abundance and genomic redundancy...

Insects have evolved diverse strategies to protect their genome-reduced symbionts during vertical transmission. Here, authors show that tortoise beetles have co-opted a Yellow protein to form spheres ...

Issue #13

From pursuing an impossible dream to uncovering one of the cell’s best-kept secrets and advancing the design of improved antibiotics

The country singer was an advocate for vaccines, public health, literacy and marginalized communities.

Bacterial ribosomal RNAs (rRNAs) are decorated with conserved nucleotide modifications, but the functionality of these modifications is often underexplored. MraW (RsmH) is a 16S rRNA methyltransferase. Here, we report that deletion of mraW corrects a late-stage sporulation defect in Bacillus subtili …

Wolfgang R Hess, Kai Papenfort, Cynthia M Sharma, Franz Narberhaus, Ruth A Schmitz; Small proteins in prokaryotes, a fascinating world, microLife, , uqag02

Abstract. Toxin–antitoxin (TA) systems use diverse strategies to control bacterial growth and represent attractive therapeutic targets to fight pathogens.

Ribosome composition can vary through differences in associated proteins, post-transcriptional and post-translational modifications. Such heterogeneity enables ribosomes to respond to environmental[1]...

Federal research funding shapes the direction, diversity, and impact of the US scientific enterprise. Large language models (LLMs) are rapidly diff...

Abstract. Ribosomal RNA (rRNA) modifications cluster around the peptidyl transferase centre (PTC), the catalytic centre of the ribosome, yet their collecti

NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Request for Information (RFI) on Proposed Changes to Reporting Outcomes from NIH Peer Review NOT-OD-26-088. NIH

Northwestern scientists have identified a novel mechanism utilized by the bacteria responsible for gonorrhea to evade immune detection and achieve widespread infection, according to a recent study pub...

Bacterial gene expression depends on the coordinated regulation of RNA synthesis, processing, and decay. The conserved RNA degradosome scaffold, Ribonuclease E (RNase E), assembles into phase-separate...

Phages often degrade the genome of their bacterial host to individual nucleotides. Here we describe Metis, a bacterial defense system that directly senses phage-mediated host genome degradation. Metis...

Here we introduce OpenEvo, a fully open-source, low-cost turbidostat platform for automated continuous culture and directed evolution experiments. Existing tools are expensive, complex, or lack open-s...

Abstract. Transfer RNAs (tRNAs) are essential for protein synthesis and are extensively modified to ensure their structure and function. Direct RNA sequenc

Current Employees: If you are currently employed at any of the Universities of Wisconsin, log in to Workday to apply through the internal application process.Job Category:Academic StaffEmployment Type...

Oxidative phosphorylation is the most efficient way of generating ATP in respiring cells. As high energy electrons are the major source of reactive oxygen species their production needs to be carefull...