Firmicutes are gram-positive bacteria with important roles in human health, disease, and industry. However, more than a quarter of genes in the mod...

RNA modifications play an important role in biological processes. Mapping the diversity of RNA chemistry and studying the biological function of in...

Bacillus subtilis Ncp and NADH dehydrogenase form tube-like filaments with phospholipid-lined chambers that associate with quinones, which can expand bioenergetic capacity and support respiratory elec...

Abstract. Bacteria employ sophisticated post-transcriptional regulatory mechanisms to adapt to environmental changes. Carbon storage regulator A (CsrA), a

Biosynthetic needs of a cell and the generation of precursors and energy in catabolic reactions must be faithfully balanced. Even in model organisms s…

Transcriptional regulation is a central mechanism underlying bacterial adaptation to stress. Here, the authors used a genetic fitness screen to show that the Y-complex in Bacillus subtilis contributes...

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Bacteria utilize a variety of mechanisms to remodel the cell wall in response to environmental and antimicrobial stress. In the model organism Bacillu…

Koo et al. apply genome-scale double-CRISPRi to map cell envelope gene interactions in Bacillus subtilis, revealing >1,000 genetic interactions and uncovering gene networks in envelope biogenesis and ...

Using bioinformatics for identifying and plugging metabolic pathway holes

Here, the authors describe a tubular module connecting oxidoreductases to the membrane. This system, found in many microorganisms, reveals a distinct mode of membrane anchoring and an electron transfe...

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Abstract. Recent evidence indicates that the bacterial Rho helicase regulates Bacillus subtilis gene expression in a growth-dependent manner. This regulati

Metal ions are required for all cells, and their homeostasis relies on ancient mechanisms that facilitate their import, distribution and storage. In this Review, Helmann discusses the key chemical con...

Accurate prediction of protein complex structures by AlphaFold3 and similar programs has been successfully used to predict the presence of protein-protein interactions (PPIs), but this technique has n...

Author summary Bacterial endospores allow bacteria to survive stress, persist in the environment and seed new and recurring infections. Cell-cell signalling is a cornerstone of how bacteria develop in...

Nature Microbiology - Brogan et al. uncover a signalling pathway in which levels of the nucleotide second messenger c-di-AMP increase in response to defects in cell wall synthesis. This regulatory...

Developmental processes are carefully regulated programs that are present in multiple kingdoms of life and that generally result in cell differentiation and specialization. This regulation can be medi...