In this Primer, Chang and colleagues review the epidemiology, pathophysiology, diagnosis and management of irritable bowel syndrome (IBS) as well as the quality of life of individuals with IBS — a prevalent disorder of gut–brain interaction characterized by recurrent abdominal pain or discomfort associated with altered bowel habits.

This Primer discusses the epidemiology, mechanisms, diagnosis and treatment of Chiari I malformation.

This PrimeView summarizes mechanisms, diagnosis and management of classical toxidromes - characteristic patterns of clinical features caused by poisonings with specific xenobiotics. It accompanies the Primer on this topic by Roberts et al.

Toxidromes are characteristic patterns of clinical features caused by specific toxic mechanisms that support clinical management of the poisoned patient. In this Primer, Roberts et al. summarize the e...

Primary infection of varicella zoster virus causes varicella (chickenpox). Virus reactivation later in life can cause herpes zoster (shingles) and other neurological and systemic complications. In this Primer, Bubak et al. describe the epidemiology, mechanisms, diagnosis and management of varicella zoster virus infection, and highlight patients’ quality of life and questions for future research.

This PrimeView highlights the diagnosis of Methicillin-resistant Staphylococcus aureus and accompanies the Primer article on this topic by Parsons et al.

Methicillin-resistant Staphylococcus aureus (MRSA) is a leading cause of antimicrobial-resistant infection. In this Primer, Parsons and colleagues describe the epidemiology of MRSA, discuss the mechan...

Influenza viruses cause seasonal epidemics and periodic pandemics, making them a considerable public health concern. In this Primer, Neumann and colleagues describe the epidemiology, mechanisms, diagn...