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Paul Hoskisson 🧫 🦠🐸

@paulhoskisson.bsky.social
4.6K followers 3.8K following 386 posts

Professor of Molecular Microbiology, Fellow of the Royal Society of Edinburgh, Editor at Microbial Genomics & mBio, Scouse, interested in Streptomyces, Evolution, Antibiotics, AMR, microbiology, Phage, herpetology, Cricket, EvertonFC

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Paul Hoskisson 🧫 🦠🐸 @paulhoskisson.bsky.social · 24/09/2026
Not read this in detail yet…but looks interesting and thought provoking….will it help or add fuel to fires on discussions around lab releases of organisms? Language-Model-Based Detection of Genetic Editing in Bacteria www.biorxiv.org/content/10.6...
biorxiv.org
Language-Model-Based Detection of Genetic Editing in Bacteria
Recent advances in genome editing allow easy genetic manipulation of bacteria, providing them with new traits, some of which could be hazardous, e.g. enhanced virulence or extended resistance to antib...
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FishEvo Zuzana Musilova @fishevo.bsky.social · 22/09/2026
Hot off the preprint: visual adaptations in crater-lake #cichlids revealed by single-cell RNA-seq of the retina. Deep-water species have mainly green cones that however differ from both green and red cones of the shallow-water species. Quite unexpected in such young adaptive radiation!😍
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Richard Lenski @relenski.bsky.social · 22/09/2026
"Philosophy of Biology: The power of theory in the life sciences" elifesciences.org/articles/112... @zdblount.bsky.social shared this thought-provoking paper with the lab group.
elifesciences.org
Philosophy of Biology: The power of theory in the life sciences
Theory can help address cell and molecular biology’s major challenges, particularly those arising from large omics datasets.
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Rosemary Mosco @rosemarymosco.com · 22/09/2026
Happy mushroom season!
A comic titled "Types of mushrooms" with 12 mushroom species. A wrinkly-looking morel is labeled "creepy but tasty". A brownish deadly galerina is labeled "boring but deadly". A witch's butter on a branch is labeled "jiggles if you poke it". A large puffball is labeled "egg". A creepy red-dripping bleeding tooth fungus is labeled "deeply disconcerting". A fly agaric with a green treefrog sitting under it is labeled "frog umbrella". A black chanterelle is labeled "chalice for forbidden elixers". Three straight-stemmed entolomas are labeled "haha, nipples". A bright purple viscid violet cort is labeled "purple is nice". A birch polypore sticking out of a birch trunk is labeled "tree nose". A complex yellow-tpped coral fungus is labeled "cursed citadel where dwells a fairy queen". A Ravenel's stinkhorn is pixellated at the top for your safety, and labeled "NSFW".
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Paul Hoskisson 🧫 🦠🐸 @paulhoskisson.bsky.social · 22/09/2026
This is very cool @kelleygallagher.bsky.social et al Regulatory divergence and functional diversification of a c-di-GMP-controlled sigma factor in Actinomycetota doi.org/10.1128/msys...
doi.org
Regulatory divergence and functional diversification of a c-di-GMP-controlled sigma factor in Actinomycetota | mSystems
Mounting global responses to dynamic environmental conditions is a crucial function that bacterial cells must perform. Global regulatory networks are most often studied in individual species, however,...
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Reposted by Paul Hoskisson 🧫 🦠🐸
Artologica aka Michele Banks @artologica.net · 14/09/2026
Attention #sciart people! The ASM agar art contest is open. Deadline is October 21 🧪🧫
asm.org
ASM Agar Art Contest | Contest Details
Have you ever seen art created in a petri dish using living, growing microorganisms? That's agar art! ASM's annual Agar Art Contest is a chance for you to use science to show off your creative skills.
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Paul Hoskisson 🧫 🦠🐸 @paulhoskisson.bsky.social · 13/09/2026
The bird that changed Ecuador: how a chance discovery of a rare species helped to save many more www.theguardian.com/environment/...
theguardian.com
The bird that changed Ecuador: how a chance discovery of a rare species helped to save many more
Thirty years after a US ornithologist first sighted a jocotoco antpitta, the foundation he set up to restore biodiversity is a model for conservation globally
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Paul Hoskisson 🧫 🦠🐸 @paulhoskisson.bsky.social · 13/09/2026
Fascinating stuff - Acquisition and erosion of toxin-antitoxin systems in bacterial chromosomes academic.oup.com/mbe/advance-...
academic.oup.com
Acquisition and erosion of toxin-antitoxin systems in bacterial chromosomes
Abstract. Toxin-antitoxin systems (TAs) are widespread in bacterial genomes. Yet, their integration, persistence, and impact in chromosome dynamics remain
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Paul Hoskisson 🧫 🦠🐸 @paulhoskisson.bsky.social · 11/09/2026
Really important from @ellinoralseth.bsky.social & @brownlab.bsky.social - a framework for defense as an evolved adaptation, in a world where ‘defense’ & ‘immune’ are often used to mean anti-infection The bacterial immune system: identifying evolved defense adaptations www.cell.com/trends/micro...
cell.com
The bacterial immune system: identifying evolved defense adaptations
Recent years have witnessed a rapid expansion in bacterial defense mechanisms. Alongside established defenses against molecular parasites, hundreds of novel mechanisms are being described annually, co...
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Paul Hoskisson 🧫 🦠🐸 @paulhoskisson.bsky.social · 09/09/2026
Wow, this is getting fascinating with these NADases - seems pretty widespread - three BioRxivs on this exciting antiviral system in a matter of months from the Ibarra-Chavez lab www.biorxiv.org/content/10.6... and Tagliabracci lab www.biorxiv.org/content/10.6...
biorxiv.org
Antimicrobial-resistance plasmids encode Evangelion, a widespread DUF4062 anti-phage defence family
Many bacterial anti-phage defence systems are encoded by mobile genetic elements, yet much of this antiviral repertoire remains undiscovered. Antimicrobial-resistance plasmids are well known for disse...
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Paul Hoskisson 🧫 🦠🐸 @paulhoskisson.bsky.social · 07/09/2026
Great collection in Essays Biochem on the social lives of bacteria - put together by @friendlymicrobe.bsky.social & @rachelwheatley.bsky.social doi.org/10.1042/EBC2... happy to contribute with ‘Colony politics to chemical warfare: phenotypic plasticity in #Streptomyces’ doi.org/10.1042/EBC20250034
portlandpress.com
A special issue of Essays in Biochemistry on the social lives of bacteria
Abstract. The study of bacterial sociality, understanding when and how bacteria interact and the consequences of those interactions, has rapidly grown in popularity over the last 20 years. This has re...
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Paul Hoskisson 🧫 🦠🐸 @paulhoskisson.bsky.social · 25/08/2026
Super collection of essays here in ‘Essays in Biochemistry’ @biochemsoc.bsky.social focussed on Bacterial Biosynthetic Gene Clusters - lots of interesting perspectives portlandpress.com/essaysbioche... all pulled together by @evodivmet.bsky.social
portlandpress.com
Volume 70 Issue 2 | Essays in Biochemistry | Portland Press
Essays in Biochemistry publishes short, digestible reviews from experts highlighting recent key topics in biochemistry and the molecular biosciences. Written to be accessible for those not yet immerse...
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Kathryn R Elmer @profkathrynelmer.bsky.social · 25/08/2026
We have a ca 1.5 yr postdoc available in our team, asking, 'what is the shape of the fitness landscape between oviparity and viviparity?' and 'what drives viviparity to evolve'? 🧬 using 🦎 as a model. closes 16 Sept. Details on EvolDir evoldir.net/brian/evoldi... @glasgow.ac.uk @sbohvm.gla.ac.uk
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Paul Hoskisson 🧫 🦠🐸 @paulhoskisson.bsky.social · 25/08/2026
This is super cool from @ecoevoevoeco.bsky.social & @danielbolnick.bsky.social et al Eco-Evolutionary Dynamics of Infection and Immunity in Experimentally Founded Lake Populations of Threespine Stickleback www.journals.uchicago.edu/doi/10.1086/...
journals.uchicago.edu
Eco-Evolutionary Dynamics of Infection and Immunity in Experimentally Founded Lake Populations of Threespine Stickleback | The American Naturalist: Vol 208, No 3
AbstractHost-parasite interactions are likely to involve eco-evolutionary feedbacks. Parasites can impose strong selection on host immune traits. Evolution of these traits can suppress parasite abunda...
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Paul Hoskisson 🧫 🦠🐸 @paulhoskisson.bsky.social · 24/08/2026
Really cool paper from @sheppardlab.bsky.social et al Accelerating Campylobacter zoonosis in the Anthropocene www.pnas.org/doi/10.1073/... - and I was delighted to be invited to write a commentary about this lovely work too www.pnas.org/doi/10.1073/...
pnas.org
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
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Paul Hoskisson 🧫 🦠🐸 @paulhoskisson.bsky.social · 20/08/2026
A bacterial metabolite rewires fungal metabolism, triggering the hyphae-to-yeast transition www.cell.com/current-biol...
cell.com
A bacterial metabolite rewires fungal metabolism, triggering the hyphae-to-yeast transition
The hyphae-to-yeast morphological transition promotes dissemination of the pathogen Candida albicans, but the mechanisms underlying this process are poorly defined. By identifying a bacterial metaboli...
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Paul Hoskisson 🧫 🦠🐸 @paulhoskisson.bsky.social · 20/08/2026
Beautiful work from @profkathrynelmer.bsky.social et al Genome-wide barriers to gene flow reveal the genetic basis of viviparity evolution in a lizard www.cell.com/current-biol...
cell.com
Genome-wide barriers to gene flow reveal the genetic basis of viviparity evolution in a lizard
Xie et al. resolve the complex and dynamic evolutionary history of viviparity emergence in an amniote, the common lizard. They demonstrate a key involvement of gene regulatory regions, found genome wi...
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Paul Hoskisson 🧫 🦠🐸 @paulhoskisson.bsky.social · 02/08/2026
Couple of gorgeous Adders (Vipera berus) from this mornings walk - always a joy to see these
Adder
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Shu-Sin Chng @figlegend.bsky.social · 05/07/2026
Intense week of science at Bacterial Cell Surfaces GRC! Best part was catching up with old/new friends! Tagging peeps in pics @paulhoskisson.bsky.social @hendersonlab.bsky.social @namurxa.bsky.social @sujeetkumar.bsky.social @weeboont.bsky.social @yeowjiang.bsky.social @siegristpalmore.bsky.social
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Paul Hoskisson 🧫 🦠🐸 @paulhoskisson.bsky.social · 01/07/2026
really lovely piece of work from @raufs.bsky.social et al., Complex multicellularity is linked with expanded specialized metabolite production in microorganisms www.nature.com/articles/s41...
nature.com
Complex multicellularity is linked with expanded specialized metabolite production in microorganisms - Nature Microbiology
The evolutionary emergence of complex multicellularity in bacteria and fungi, such as the ability for mycelial growth, is strongly associated with increased genomic carriage of biosynthetic machinery ...
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Paul Hoskisson 🧫 🦠🐸 @paulhoskisson.bsky.social · 30/06/2026
this is very cool - Chemical ecology and convergent evolution of natural hallucinogens: From ecological defense to conserved neural targets www.pnas.org/doi/10.1073/...
pnas.org
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
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Paul Hoskisson 🧫 🦠🐸 @paulhoskisson.bsky.social · 29/06/2026
Cool new preprint of a new defence family! Antimicrobial-resistance plasmids encode Evangelion, a widespread DUF4062 anti-phage defence family www.biorxiv.org/content/10.6...
biorxiv.org
Antimicrobial-resistance plasmids encode Evangelion, a widespread DUF4062 anti-phage defence family
Many bacterial anti-phage defence systems are encoded by mobile genetic elements, yet much of this antiviral repertoire remains undiscovered. Antimicrobial-resistance plasmids are well known for disse...
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Reposted by Paul Hoskisson 🧫 🦠🐸
George O'Toole (he/him/his) @geiselbiofilm.bsky.social · 23/06/2026
Our Dept of Microbiology & Immunology @Geisel School of Medicine @Dartmouth has an opening for an Assistant Professor. Looking for programs bridging multiple areas in Micro & Immuno. A great place to be! Programs: www.M2P2.org www.dartmouthbiofilm.org Job ad: apply.interfolio.com/187637
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Paul Hoskisson 🧫 🦠🐸 @paulhoskisson.bsky.social · 23/06/2026
First ‘Charles Darwin’ Rose of the year has opened in the garden!
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Royal Society Publishing @royalsocietypublishing.org · 23/06/2026
New research from #BiologyLetters: Song but not colour divergence constrains hybridization in birds doi.org/10.1098/rsbl... | #Evolution #Birdsong #Colouration
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Royal Society Publishing @royalsocietypublishing.org · 15/06/2026
A type of natural selection known as negative frequency dependent selection is thought to be a major force promoting genetic diversity in important traits. Read research in a new issue of #PhilTransB: buff.ly/bOhpNlE
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Russ Jones @russincheshire.bsky.social · 22/06/2026
In the future, everybody will be Prime Minister for 15 minutes — Andy Narwhal
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Paul Hoskisson 🧫 🦠🐸 @paulhoskisson.bsky.social · 22/06/2026
This is an awesome review from @sheppardlab.bsky.social - Epistasis and co-adaptation in bacterial genome #evolution www.nature.com/articles/s41...
nature.com
Epistasis and co-adaptation in bacterial genome evolution - Nature Reviews Genetics
Bacterial genome evolution is shaped by epistasis, which can constrain or promote specific evolutionary paths. The authors review how integrating the effects of epistatic interactions into population-...
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Princeton Vaughn @princetonvaughn.bsky.social · 15/06/2026
I’m honored to receive this year’s Hamilton Award at Evolution! It was such a privilege to be surrounded by so many outstanding scientists doing such incredible work!
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Paul Hoskisson 🧫 🦠🐸 @paulhoskisson.bsky.social · 12/06/2026
This is excellent from @roysleator.bsky.social www.nature.com/articles/d41...
nature.com
Science must be seen as a viable profession for the many, not the few
Letter to the Editor
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Paul Hoskisson 🧫 🦠🐸 @paulhoskisson.bsky.social · 11/06/2026
Recently back from an amazing #Herping trip to #Albania and managed to see Europes smallest and rarest Viper - the Greek Meadow Viper (Vipera graeca), lots of careful searching at 1900 metres resulted in finding a beautiful, sub-adult female
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Paul Hoskisson 🧫 🦠🐸 @paulhoskisson.bsky.social · 11/06/2026
wow- The evolution of high-order genome architecture revealed from 1,000 species www.cell.com/cell/abstrac...
cell.com
The evolution of high-order genome architecture revealed from 1,000 species
Comparative Hi-C analysis across 1,025 species reveals that genome architecture has evolved along distinct trajectories, with plants favoring global folding and animals developing checkerboard compart...
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Paul Hoskisson 🧫 🦠🐸 @paulhoskisson.bsky.social · 11/06/2026
#Academia is essentially, repeatedly adding the same information in to a range of different forms on a daily basis
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Paul Hoskisson 🧫 🦠🐸 @paulhoskisson.bsky.social · 04/06/2026
Mind blown! 🤯 Spontaneous problem-solving in bumble bees www.science.org/doi/10.1126/...
science.org
Spontaneous problem-solving in bumble bees
Problem-solving using novel solutions without explicit training is often considered a hallmark of cognitive flexibility. We investigated whether bumble bees (Bombus terrestris) could solve a novel obj...
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Tue Sparholt Jørgensen @tuesparholt.bsky.social · 15/10/2025
Bacterial telomeres are common, just not so much in RefSeq 'complete' genomes. But they can be added by the new tool David Faurdal wrote. I am thrilled to see this out as a preprint here: www.biorxiv.org/content/10.1... @tilmweber.bsky.social @thombooth.bsky.social
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Paul Hoskisson 🧫 🦠🐸 @paulhoskisson.bsky.social · 02/06/2026
Island-Hopping Frogs: How Geology, Ocean Currents and Evolution Shaped Biodiversity in the Pacific www.linnean.org/news/2026/04...
linnean.org
Island-Hopping Frogs: How Geology, Ocean Currents and Evolution…
Discover the latest news from The Linnean Society of London.
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Paul Hoskisson 🧫 🦠🐸 @paulhoskisson.bsky.social · 30/05/2026
@countryman100.bsky.social rooting for you guys tonight!
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Paul Hoskisson 🧫 🦠🐸 @paulhoskisson.bsky.social · 27/05/2026
Evolution of genome-wide barriers to gene flow during complex speciation in rattlesnakes - www.pnas.org/doi/10.1073/...
pnas.org
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
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Paul Hoskisson 🧫 🦠🐸 @paulhoskisson.bsky.social · 27/05/2026
This is cool - ‘Descent from a common ancestor restricts exploration of protein sequence space’ - www.pnas.org/doi/10.1073/... & a great commentary piece too- ‘Maynard Smith’s analogy, realized: Common ancestry constrains evolutionary percolation through protein space’ www.pnas.org/doi/10.1073/...
pnas.org
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
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Matt Hutchings @handle.invalid · 18/05/2026
Good to see this @microbiologysociety.org cross journal special collection taking shape: Advances in the biology of Actinomycetes www.microbiologyresearch.org/content/adva...
microbiologyresearch.org
Advances in the biology of Actinomycetes | Microbiology Society
The Actinomycetota are amongst the most diverse bacterial phyla with representatives found globally in a wide range of ecological niches. To reflect this biological diversity, the 20th International S...
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Paul Hoskisson 🧫 🦠🐸 @paulhoskisson.bsky.social · 05/05/2026
This is a really cool study - Convergent evolution of aerobic fermentation through divergent mechanisms acting on key shared glycolytic genes link.springer.com/article/10.1...
link.springer.com
Convergent evolution of aerobic fermentation through divergent mechanisms acting on key shared glycolytic genes - The EMBO Journal
As the tree of life becomes increasingly accessible to molecular investigations, describing mechanisms underlying evolutionary convergence and constraint will be crucial to understanding diversificati...
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Lis Lowe @lislowe.bsky.social · 29/04/2026
We have a PhD studentship open! (UK only sadly) but if you are or know a student keen to work on some *really* weird mycobacterial enzymes then get in touch! #glycotime Advert below www.findaphd.com/phds/project...
findaphd.com
Uncovering a new class of toxins in pathogenic mycobacteria at Newcastle University on FindAPhD.com
PhD Project - Uncovering a new class of toxins in pathogenic mycobacteria at Newcastle University, listed on FindAPhD.com
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Michael Brockhurst @brockhurstlab.bsky.social · 28/04/2026
We have a PhD studentship available to develop genome safeguarding technologies for synthetic phage therapeutics www.findaphd.com/phds/project... It is part of an exciting new @officialuom.bsky.social PhD by Enterprise programme www.bmh.manchester.ac.uk/study/resear...
findaphd.com
(PhD by Enterprise) Genome safeguarding technologies for synthetic phage therapeutics against multidrug resistant bacterial infections at The University of Manchester on FindAPhD.com
PhD Project - (PhD by Enterprise) Genome safeguarding technologies for synthetic phage therapeutics against multidrug resistant bacterial infections at The University of Manchester, listed on FindAPhD...
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BTO | British Trust for Ornithology @btobirds.bsky.social · 24/04/2026
Another three satellite-tagged Cuckoos have made it back to the UK and Ireland! 🙌 To sponsor a Cuckoo and follow their migrations on our interactive map visit www.bto.org/cuckoos. Thank you. 💚
A map showing the migrations of Cuckoo Sayaan from the UK to Africa and back again, with his current location in the UK. A headshot of Cuckoo Sayaan features, alongside the wording: Sayann left the Pyrenees and set off across France, covering almost 620 miles before arriving on the English coast. He then headed inland to the Knepp Estate where he was tagged in 2023. He returned five days earlier this year than he did last spring!
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Paul Hoskisson 🧫 🦠🐸 @paulhoskisson.bsky.social · 23/04/2026
Come and study for a PhD with us on antibiotic-producing Streptomyces, trying to understand the roles of primary metabolic enzymes with additional cellular roles - Details below - please repost www.findaphd.com/phds/project...
findaphd.com
Primary metabolic enzymes in antibiotic-producing Streptomyces bacteria, but not as we know them! at University of Strathclyde on FindAPhD.com
PhD Project - Primary metabolic enzymes in antibiotic-producing Streptomyces bacteria, but not as we know them! at University of Strathclyde, listed on FindAPhD.com
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Paul Hoskisson 🧫 🦠🐸 @paulhoskisson.bsky.social · 10/04/2026
Cool paper from the ISBA collection (www.microbiologyresearch.org/content/adva... ) from @evodivmet.bsky.social et al Functional shifts of the dual-substrate phosphoribosyl isomerase PriA from primary to specialized metabolism in rare Actinomycetota www.microbiologyresearch.org/content/jour...
microbiologyresearch.org
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Paul Hoskisson 🧫 🦠🐸 @paulhoskisson.bsky.social · 10/04/2026
Really cool work from @mblokesch.bsky.social et al Competence-mediated DNA uptake diversifies Vibrio cholerae sedentary chromosomal integrons www.science.org/doi/10.1126/...
science.org
Competence-mediated DNA uptake diversifies Vibrio cholerae sedentary chromosomal integrons
Bacteria often survive viral attack and environmental stress by sharing genes that enhance their defenses. The cholera pathogen Vibrio cholerae carries a sedentary chromosomal integron (SCI), a genetic element containing hundreds of mostly promoterless ...
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Paul Hoskisson 🧫 🦠🐸 @paulhoskisson.bsky.social · 23/03/2026
@christianlandry.bsky.social thanks for the SMBE talk today Christian, wonderful work!
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Microbetv @microbetv.bsky.social · 19/03/2026
Paul Hoskisson discusses the Streptomyces genus; the soil microbes behind many of our most important antibiotics and a cornerstone of the antibiotic revolution. Excerpt from Matters Microbial 125: Antibiotics, Streptomyces and Evolution @markowenmartin.bsky.social @paulhoskisson.bsky.social
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