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Yanjie Chao

@yjchao.bsky.social
74 followers 47 following 7 posts

Bacterial RNA Biologist, Group Leader and Professor at Chinese Academy of Sciences, Shanghai Institute of Materia Medica (Formerly Institut Pasteur of Shanghai). Homepage: yanjiechao.wordpress.com

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Yanjie Chao @yjchao.bsky.social · 25/02/2026
Major Chinese funder to stop paying fees for 30 pricey open-access journals | Science | AAAS www.science.org/content/arti...
science.org
Major Chinese funder to stop paying fees for 30 pricey open-access journals
Move comes amid effort to grow the country’s own journals
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Helmholtz Institute Würzburg @helmholtz-hiri.bsky.social · 28/01/2026
🚨 Group Leader Opportunity Alert! 🚀 Apply by February 15 and join us in Würzburg. ⬇️
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Aaron Whiteley @aaronwhiteley.bsky.social · 18/01/2026
I’m thrilled to share our work on phage triggers of the bacterial immune system in its final form @natmicrobiol.nature.com www.nature.com/articles/s41...
nature.com
A phage protein screen identifies triggers of the bacterial innate immune system - Nature Microbiology
A library of 400 phage protein-coding genes is used to find a trove of antiphage systems, revealing systems that target tail fibre and major capsid proteins.
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Sorek Lab @soreklab.bsky.social · 05/01/2026
NLR-like immunity in bacteria A new study from the Alex Gao lab. The scope of this work is incredible!!! www.biorxiv.org/content/10.6...
biorxiv.org
Diverse bacterial pattern recognition receptors sense the conserved phage proteome
Recognition of foreign molecules inside cells is critical for immunity in all domains of life. Proteins of the STAND NTPase superfamily, including eukaryotic nucleotide-binding oligomerization domain ...
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Nature Microbiology @natmicrobiol.nature.com · 05/01/2026
Nature Microbiology turns 10! 🎂 As a special treat, we take you back to the editorial team that started it all and then fast forward to take a peek into the future of microbiology through some brilliant microbiologists. #MicroSky 🦠 www.nature.com/nmicrobiol/v...
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Aude Bernheim @audeber.bsky.social · 15/12/2025
Bacterial genomes encode a rich repertoire of antiphage systems, but we still know surprisingly little about when these systems are actually expressed. In this preprint, Lucas Paoli et al, ask what shapes antiphage systems expression in native contexts. www.biorxiv.org/content/10.6...
biorxiv.org
Environment and physiology shape antiphage system expression
Bacteria and archaea encode on average ten antiphage systems. Quorum sensing, cellular, or transcription factors can regulate specific systems (CRISPR-Cas, CBASS). Yet, a systematic assessment of anti...
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Chuan Wang @chuanwangfdu.bsky.social · 04/12/2025
How does a bacterial small RNA evolve new functions? Our new study reveals the stepwise evolutionary journey of UhpU, a 3′UTR-derived sRNA in E. coli and relatives. It evolved from a metabolically-focused regulator to one with expanded targets and biogenesis manner. www.pnas.org/doi/10.1073/...
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Joe Bondy-Denomy @jbdsf.bsky.social · 01/12/2025
Check this out for the 2026 SISB (phage defense) meeting in NYC. Mark your calendar! (and note the Zoom option, if needed) sisb2026.rockefeller.edu
sisb2026.rockefeller.edu
SISB2026
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Sarah Svensson @campy-bara.bsky.social · 19/11/2025
Sharing the link to our updated Vibrio preprint, where we compare and contrast Ecospecies with other genetic structures, and using the opportunity to fix typos and update some bluesky handles! with @danielfalush.bsky.social @whqqq.bsky.social @yjchao.bsky.social @chaooo.bsky.social
biorxiv.org
Evolution of hunt, kill, devour in a Vibrio ecospecies
Bacterial ecospecies are a recently recognized genetic structure that is hypothesized to arise by complex adaptation to a new niche. Coadaptation within the “Molassodon” ecospecies of Vibrio parahaemo...
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Sorek Lab @soreklab.bsky.social · 06/11/2025
Preprint: Bacteria sense virus-induced genome degradation via methylated mononucleotides tinyurl.com/ch3damp We show how molecular byproducts released during virus-induced cell exploitation are used as signals to trigger host immunity Revealed by the amazing Ilya Osterman. See his thread below👇
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Yanjie Chao @yjchao.bsky.social · 23/10/2025
I'm happy to co-organize the 2nd Microbial RNA Symposium in Shanghai! Looking forward to these inspiring talks this weekend! @rnasociety.bsky.social @natmicrobiol.nature.com @cellpress.bsky.social
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Sternberg Lab @sternberglab.bsky.social · 17/10/2025
1/10 Genome maintenance by telomerase is a fundamental process in nearly all eukaryotes. But where does it come from? Today, we report the discovery of telomerase homologs in a family of antiviral RTs, revealing an unexpected evolutionary origin in bacteria. www.biorxiv.org/content/10.1...
biorxiv.org
Antiviral reverse transcriptases reveal the evolutionary origin of telomerase
Defense-associated reverse transcriptases (DRTs) employ diverse and distinctive mechanisms of cDNA synthesis to protect bacteria against viral infection. However, much of DRT family diversity remains ...
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Géraldine Laloux @lalouxlab.bsky.social · 17/09/2025
🚨New paper out! #MicroSky Studying obligate predators like Bdellovibrio bacteriovorus is tricky—essential genes for predation are also essential for survival. We expanded its genetic toolbox: 🧬promoters to fine-tune expression 🧬IPTG-inducible system 🧬CRISPRi for rapid knockdown bit.ly/46GUn2c 1/4
academic.oup.com
Expanding the genetic toolbox of the obligate predatory bacterium Bdellovibrio bacteriovorus with inducible gene expression and CRISPR interference
Inducible gene expression and CRISPR interference-mediated depletion in the predatory bacterium Bdellovibrio bacteriovorus.
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Nature Ecology & Evolution @natecoevo.nature.com · 27/08/2025
Combination of large-scale phylogenomic analysis, mouse lethality experiments and bacterial growth assays shows sheds light on how a pandemic clone of Vibrio parahaemolyticus was able to spread worldwide www.nature.com/articles/s41...
nature.com
Wave succession in the pandemic clone of Vibrio parahaemolyticus driven by gene loss - Nature Ecology & Evolution
A combination of large-scale phylogenomic analysis, mouse lethality experiments and bacterial growth assays shows that gene loss in the putrescine utilization pathway has enhanced biofilm formation an...
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Zeynep Baharoglu @zeynepbaharoglu.bsky.social · 28/07/2025
tRNA modification profiling reveals epitranscriptome regulatory networks in Pseudomonas aeruginosa 🦠👏High-throughput tRNA epitranscriptome profiling using mass spec on P. aeruginosa transposon insertion library and links with metabolic networks #microsky #rnasky doi.org/10.1093/nar/...
doi.org
tRNA modification profiling reveals epitranscriptome regulatory networks in Pseudomonas aeruginosa
Abstract. Transfer RNA (tRNA) modifications have emerged as critical post-transcriptional regulators of gene expression affecting diverse biological and di
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Kröger Lab @kroegerlab.bsky.social · 21/07/2025
New preprint! We characterise the small, regulatory RNA Arp which controls DNA uptake and twitching motilty in A. baumannii. Led by our Dr Fergal Hamrock @hamrockfergal.bsky.social and in collaboration with @westermannlab.bsky.social and Mike Gebhardt's lab!
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Dr Sariqa Wagley @sariqawagley.bsky.social · 04/07/2025
Evolution of hunt, kill, devour in a Vibrio ecospecies Great paper 'Molassodon' - genetically distinct ecospecies from typical V. parahaemolyticus, it has evolved a predatory strategy that devour other bacteria in viscous environments @campy-bara.bsky.social www.biorxiv.org/content/10.1...
biorxiv.org
Evolution of hunt, kill, devour in a Vibrio ecospecies
Bacterial ecospecies are a recently recognized genetic structure that is hypothesized to arise by complex adaptation to a new niche. Using coadaptation analysis as a foundation for laboratory experime...
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Nature Microbiology @natmicrobiol.nature.com · 04/07/2025
#NatMicroPicks Vibrio in competition! 🦠💉 An orphan T6SS effector in non-toxigenic Vibrio cholerae targets susceptible strains by disrupting ion balance, shaping Vibrio population dynamics and offering a model for precision antimicrobials. #MicroSky www.cell.com/cell-host-mi...
cell.com
A Vibrio-specific T6SS effector reshapes microbial competition by disrupting Vibrio bioenergetics
Liu et al. report that a Vibrio-specific T6SS effector, TseVs, selectively disrupts Vibrio bioenergetics while sparing non-target microbes via an immunity-independent mechanism. This work reveals how ...
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Sarah Svensson @campy-bara.bsky.social · 30/06/2025
Happy to share the preprint from here in Shanghai, together with @danielfalush.bsky.social, as well as with team Zhizhou Jia, Huqi Wen, and Zhe Xie! www.biorxiv.org/content/10.1...
biorxiv.org
Evolution of hunt, kill, devour in a Vibrio ecospecies
Bacterial ecospecies are a recently recognized genetic structure that is hypothesized to arise by complex adaptation to a new niche. Using coadaptation analysis as a foundation for laboratory experime...
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bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 07/06/2025
3'UTR-derived small RNA couples acid resistance to metabolic reprogramming of Salmonella within macrophages www.biorxiv.org/content/10.1101/202…
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Yanjie Chao @yjchao.bsky.social · 08/05/2025
Quality over quantity: Small RNA pauses translation elongation to lift protein activity: Molecular Cell www.cell.com/molecular-ce...
cell.com
Quality over quantity: Small RNA pauses translation elongation to lift protein activity
Small noncoding RNAs typically regulate the translation initiation of target mRNAs and thereby protein production. In this issue of Molecular Cell, Thongdee et al. discovered a novel regulatory mechan...
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Molecular Cell @cp-molcell.bsky.social · 06/05/2025
Quality over quantity: Small RNA pauses translation elongation to lift protein activity
dlvr.it
Quality over quantity: Small RNA pauses translation elongation to lift protein activity
Small noncoding RNAs typically regulate the translation initiation of target mRNAs and thereby protein production. In this issue of Molecular Cell, Thongdee et al. discovered a novel regulatory mechanism where a bacterial small RNA modulates translation elongation and co-translational folding to alter protein activity without affecting protein abundance.
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Jens Hör @jenshoer.bsky.social · 23/04/2025
I'm happy to share the first publication from my lab @hoerlab.bsky.social, now out in @narjournal.bsky.social! I take a look at the biology of RNA phages, focusing on how meta-omics methods are discovering new RNA phage families and bacterial defense strategies. #PhageSky doi.org/10.1093/nar/...
doi.org
Advancing RNA phage biology through meta-omics
Abstract. Bacteriophages with RNA genomes are among the simplest biological entities on Earth. Since their discovery in the 1960s, they have been used as i
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Yanjie Chao @yjchao.bsky.social · 17/04/2025
Grant opportunity! 200K USD for 3 years from CAS-ANSO program. Apply by May 20th. Details in here: www.anso.org.cn/programmes/S...
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Helmholtz Institute Würzburg @helmholtz-hiri.bsky.social · 13/03/2025
Where science meets culture 🔬🎭 At the Vogel Foundation Dr Eckernkamp’s 25th anniversary gala at the Mainfranken Theater, #HIRI director Jörg Vogel emphasized the vital role of culture for cutting-edge research. Congrats & thank you for supporting our science! ➡️ www.helmholtz-hiri.de/en/newsroom/...
© Nico Manger
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Helmholtz Institute Würzburg @helmholtz-hiri.bsky.social · 28/02/2025
📅🖍️ Mark your calendars: The #HIRI & the Shanghai #RNA Club will host @rnasociety.bsky.social’s next RNA Collaborative Seminar on March 12. HIRI group leader @jenshoer.bsky.social will discuss “Insights into the role of RNA in bacterial immunity and phage replication.” us02web.zoom.us/webinar/regi...
us02web.zoom.us
Welcome! You are invited to join a webinar: RNA Collaborative - Helmholtz Institute for RNA-based Infection Research (HIRI) & Shanghai RNA Club. After registering, you will receive a confirmation emai...
Featuring: “Insights into the role of RNA in bacterial immunity and phage replication” Jens Hör, PhD Group Leader, Helmholtz Institute for RNA based Infection Research, Junior Professor, University...
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Ben Adler @benadler.bsky.social · 26/02/2025
It is finally out! Muntathar Al-Shimary, @doudna-lab.bsky.social , @cresslab.bsky.social and I present a gene knockdown tool that works in diverse bacteriophages: CRISPRi through antisense RNA Targeting (CRISPRi-ART)! Check it out @naturemicrobiol.bsky.social www.nature.com/articles/s41...
nature.com
CRISPRi-ART enables functional genomics of diverse bacteriophages using RNA-binding dCas13d - Nature Microbiology
Leveraging RNA-targeting dCas13d enables selective interference with phage protein translation and facilitates measurement of phage gene fitness at a transcriptome-wide scale.
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ᐯIᑕTOᖇ ᑎIᘔET, ᗰᗪ @nizet.bsky.social · 25/01/2025
🅲🅾🅾🅻 🆃🅴🅲🅷🅽🅾🅻🅾🅶🆈 “Bacterial-MERFISH” provides ~1000-fold volumetric expansion of individual cells, charts gene expression in hundreds of thousands of cells, deciphering bacterial single-cell heterogeneity, intracellular transcriptome organization, and bacterial adaptation to µm-scale niches in vivo
science.org
Highly multiplexed spatial transcriptomics in bacteria
Single-cell decisions made in complex environments underlie many bacterial phenomena. Image-based transcriptomics approaches offer an avenue to study such behaviors, yet these approaches have been hin...
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Yanjie Chao @yjchao.bsky.social · 21/01/2025
My collaborators in Shanghai discovered that Within-host evolution of a transcriptional regulator contributes to the establishment of chronic Pseudomonas aeruginosa infection: Cell Reports www.cell.com/cell-reports...
cell.com
Within-host evolution of a transcriptional regulator contributes to the establishment of chronic Pseudomonas aeruginosa infection
Zhou et al. identify a 9-bp deletion in a putative transcriptional regulator in P. aeruginosa. This mutation is highly associated with chronic P. aeruginosa infection and leads to pyruvate accumulatio...
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Yanjie Chao @yjchao.bsky.social · 17/01/2025
Bacterial small RNA promotes gut colonization | EurekAlert! www.eurekalert.org/news-release...
eurekalert.org
Bacterial small RNA promotes gut colonization by regulating sialic acid metabolism
Dr. CHAO Yanjie at the Shanghai Institute of Immunity and Infection of the Chinese Academy of Sciences and Dr. WANG Chuan from Fudan University revealed how a bacterial pathogen coordinates N-acetylne...
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