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Nucleic Acids Research @narjournal.bsky.social · 29/09/2026

⭐ #NARBreakthrough ⭐ What if we could bring ancient proteins back to life? 🧬 Prof. Stoddard’s lab @fredhutch.org found that ~10% of homing endonucleases remain functional, and ancestral reconstruction reveals how these enzymes evolved new targets. Read the article here: doi.org/10.1093/nar/...

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Nucleic Acids Research @narjournal.bsky.social · 22/09/2026

✨ #NARGenomicsandBioinformatics✨ 🎯 What if you could enrich #RNAtranscripts by up to 60-fold without losing relative abundance information? Researchers @lachlanjmc.bsky.social combine RNA-guided CRISPR-Cas9 with long-read sequencing for customizable, targeted transcript enrichment. 🧬

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Nucleic Acids Research @narjournal.bsky.social · 16/09/2026

✨NAR Molecular Medicine✨ ⚠️ What happens when #DNArepair can no longer keep up? A study shows that increasing exposure to #NDMA can saturate #MGMT, triggering a burst of #mutations. A striking example of how dose shapes #DNAdamage and #cancerrisk. doi.org/10.1093/narm... @mitpress.bsky.social

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Nucleic Acids Research @narjournal.bsky.social · 28/08/2026

⭐ #NARBreakthrough ⭐ How do #IStrons juggle 3 competing functions from a single sequence? #Newstudy reveals an RNA-level #tug-of-war between #self-preservation and #hostprotection, shaped by #RNAfolding 🔬Read the article here: doi.org/10.1093/nar/...

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Nucleic Acids Research @narjournal.bsky.social · 31/07/2026

📣NAR is recruiting a new Executive Editor!📣Seeking an established researcher with expertise in RNA biology and translation mechanisms to help shape the journal's scientific direction, oversee peer review, and support its growth. Apply by 30 Sept 2026: academic.oup.com/nar/pages/ex...

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Nucleic Acids Research @narjournal.bsky.social · 20/07/2026

Congratulations to the authors on their #NARCANCER publication! 🎉 Deleterious #SMC5/6 variants may predict higher #tumormutationalburden and better responses to #immunotherapy, highlighting their potential as #biomarkers for #precisioncancertherapy.

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Nucleic Acids Research @narjournal.bsky.social · 16/07/2026

New research in #NARMolecularMedicine shows that #musclestemcells retain intrinsic #inflammatory changes, with aberrant #TNFα signaling and reduced #H3.3 impairing muscle regeneration, pointing to #newtherapeutic opportunities in #dermatomyositis beyond #interferon. 🧬 doi.org/10.1093/narm...

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Nucleic Acids Research @narjournal.bsky.social · 14/07/2026

📣The 24th annual NAR Web Server Issue is now online! 📣Explore 47 new web servers spanning a range of scientific and medical applications. Congratulations and thanks to all authors, editors and reviewers for your contributions!🧬 #NARWebServer #MolecularBiology #OpenAccessIssue

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Nucleic Acids Research @narjournal.bsky.social · 08/07/2026

📣 Applications are open for the next NAR Early Career Investigator (ECI) Advisory Board cohort! Work with Executive Editors, help shape journal strategy, and gain insight into peer review during a 2-year term. Apply by 1 Nov 2026: lnkd.in/g233ZCAf #ECR #NAR #AcademicPublishing #MolecularBiology

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Nucleic Acids Research @narjournal.bsky.social · 23/06/2026

⭐ #NARBreakthrough ⭐ 🩸🔬 Unexpected role for #ZEB1 in #redbloodcell development! ZEB1 cooperates with KLF1 to regulate #erythroidmaturation and #enucleation, revealing a new regulatory axis essential for #erythropoiesis. 🧬✨ Read the article here: doi.org/10.1093/nar/... @igmm-montpel.bsky.social

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Nucleic Acids Research @narjournal.bsky.social · 22/06/2026

⭐ #NARBreakthrough ⭐ 🔬 How do #cyanobacteria avoid overreacting to stress? New research shows that antisense RNAs keep the #stress-response gene nblA off under normal conditions, preventing damage while enabling rapid adaptation when nutrients become limiting. 📖 Read here doi.org/10.1093/nar/...

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Nucleic Acids Research @narjournal.bsky.social · 19/06/2026

⭐ #NARBreakthrough ⭐ 🔬New research reveals that #Trypanosomabrucei CRK9 and human CDK11 share a role in #RNAsplicing through #SF3B1 phosphorylation. An unexpected link with implications for #antiparasitic drug development. 📖 Read the article here: doi.org/10.1093/nar/... @uconnhealth.bsky.social

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Nucleic Acids Research @narjournal.bsky.social · 20/05/2026

Big congratulations to the authors! 🎉🦠 Using RNA-seq, this study uncovers overlooked viral RNA species and supports a premature termination model for astrovirus subgenomic RNA synthesis, resolving a long-standing replication mystery. 🔬✨ #NARMolecularMedicine #Virology @universitypress.cambridge.org

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Bill Dynan - NAR Cancer Editor @nar-cancer-editor.bsky.social · 07/05/2026

Few cancer driver mutations have been identified in promoters, maybe for technical reasons. New assay targets >3,000 promoters — hits in CDK4, SMAD3, and GATA3 in breast cancer provide promising leads for functional follow-up. academic.oup.com/narcancer/ar... #CancerGenomics #NonCoding #Promoters

academic.oup.com

Sensitive detection of somatic mutations in GC-rich cancer gene promoters

Abstract. Somatic mutations in protein-coding genes and noncoding regulatory regions are the major drivers of cancer. Only a relatively small number of som

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Nucleic Acids Research @narjournal.bsky.social · 15/05/2026

📣 Applications are open for the next Editor‑in‑Chief of NAR Cancer! 📣 Lead an open‑access journal at the forefront of nucleic acids and cancer research. We welcome applications until 1st Aug 2026. More details: academic.oup.com/narcancer/pa... #NARCancer #EditorInChief #CancerResearch

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Nucleic Acids Research @narjournal.bsky.social · 15/05/2026

⭐ #NARBreakthrough! ⭐ New #cryo-EM study reveals how #transcription factor IWS1 promotes #RNApolII #elongation. Its C-terminus contains #modularmotifs that bind elongation components, stabilizing the complex. IWS1 also competes with #RECQL5 for Pol II binding. 📖 Read here: doi.org/10.1093/nar/...

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Nucleic Acids Research @narjournal.bsky.social · 13/05/2026

⭐ #NARBreakthrough! ⭐ 🔬 New study by @magistratolab.bsky.social and @pokorna.bsky.social reveals how TAT-SF1 acts as a “molecular latch,” storing strain in #U2snRNP to drive branch-helix formation. A “loaded-spring” model for #splicingfidelity. 📖 Read the article: doi.org/10.1093/nar/...

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Nucleic Acids Research @narjournal.bsky.social · 12/05/2026

How do memories last a lifetime when proteins turn over in months? A new NAR review by Peter Cook suggests long‑term memory may stem from transcriptional gene clusters and even pyrophosphate shaping calcium signals. 📖 doi.org/10.1093/nar/... #LongTermMemory #Transcription #ReviewArticle

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Nucleic Acids Research @narjournal.bsky.social · 06/05/2026

🧬 A new review article highlights 50 years of discoveries describing DNA’s many alternative forms which have trailblazed nucleic acid research. Read the full article at academic.oup.com/nar/article/... #DNAResearch #GenomeBiology #NucleicAcidsResearch #MolecularBiology #HistoryofDNA

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Nucleic Acids Research @narjournal.bsky.social · 29/04/2026

⭐ #NARBreakthrough ⭐ New study delivers the first chromosome-level phased assemblies, uncovering >50,000 #structuralvariants and rescuing millions of #unmappable reads in BJ and IMR-90 human cell lines. 📖 Read here: doi.org/10.1093/nar/... #Genomics #CellLines #CommunityResource

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Nucleic Acids Research @narjournal.bsky.social · 27/04/2026

⭐ #NARBreakthrough! ⭐ 🔬New study shows how the #RAD52 homolog Mgm101 anneals complementary ssDNA during single-strand annealing repair, forming an unwound #duplex intermediate. #Structural insights reveal a new #therapeutic potential in #BRCA-mutant cancers. 📖 Read here: doi.org/10.1093/nar/...

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Nucleic Acids Research @narjournal.bsky.social · 24/03/2026

📣 New NARMME collection: Targeting & Harnessing Nucleic Acids for Therapeutic Discovery. Submit work on nucleic acid chemistry, delivery, mechanisms, safety, targeting & therapeutic applications. Info: lnkd.in/eipeJmaw Submit: lnkd.in/ej9GNs3B #DrugDiscovery #TherapeuticInnovation

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Nucleic Acids Research @narjournal.bsky.social · 22/04/2026

🔬 Modern #bioinformatics workflows are complex and hard to reproduce. #systemPipeR helps researchers design, run, and track analysis #pipelines in one framework, integrating R + bioinformatics tools, HPC support, and automated #reports for #transparency. Read more doi.org/10.1093/narg... #NARGAB

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Bill Dynan - NAR Cancer Editor @nar-cancer-editor.bsky.social · 13/04/2026

How does c-MYC overexpression drive transcriptional rewiring in cancer? Sundaram et al report a plausible mechanism involving co-option of TRE/AP1 sites, mainly at enhancers, rising with MYC levels and linked to repression. academic.oup.com/narcancer/ar...

academic.oup.com

MYC and AP-1 oncogenes cooperatively bind enhancers to rewire transcription

Abstract. The transcription factor c-MYC (MYC) is deregulated in ~70% of human cancers. Through de novo motif discovery analysis on published MYC ChIP-seq

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Bill Dynan - NAR Cancer Editor @nar-cancer-editor.bsky.social · 15/03/2026

HSF1 drives cancer stress resilience but is hard to target—clever screen identifies spliceosome helicase DHX8 as a druggable regulator of HSF1 splicing→HSF1 program gone, cancer loses stress defenses. Editor's Choice in NAR Cancer. #PrecisionOncology #Spliceosome academic.oup.com/narcancer/ar...

academic.oup.com

Human DEAH-box helicase 8 regulates HSF1-mediated stress response and cancer-associated pre-mRNA splicing in tumour cells

Abstract. Transcription factor heat shock factor 1 (HSF1) orchestrates the cellular stress response, promoting malignant transformation, unchecked prolifer

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Nucleic Acids Research @narjournal.bsky.social · 16/04/2026

✨A new review in #NARMolecularMedicine explores how #mitochondrialDNA inheritance, copy number changes, and coordination with the nuclear genome shape development, and how #AssistedReproductiveTechnologies may disrupt this balance. Read the review here: doi.org/10.1093/narm... #EditorsChoice

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Nucleic Acids Research @narjournal.bsky.social · 01/04/2026

⭐ #NARBreakthrough ⭐ 🧬An endosomal #mRNAtransporter uses teamwork between its 3 RNA recognition motifs (RRMs) to distinguish #accessory from #essential binding sites. Select #cargomRNAs get “VIT” (very important transcript) status for premium transport. 🚚 Read more here: doi.org/10.1093/nar/...

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Nucleic Acids Research @narjournal.bsky.social · 26/03/2026

Huge congratulations to Tomáš Brůna @tomasbruna.bsky.social and John T. Lovell @jotlovell.bsky.social on their new paper in NAR Genomics and Bioinformatics!! 🎉🚀 Absolutely fantastic work—excited to see this contribution making waves in the field! 👏🔥

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Nucleic Acids Research @narjournal.bsky.social · 24/03/2026

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Nucleic Acids Research @narjournal.bsky.social · 24/03/2026

📣 NAR Cancer Call for Papers: Seeds of Cancer, Decades of Silence. Submit work on early cancer initiation, ageing, environment, clonal evolution, genome maintenance and more before July 2026. 👉 academic.oup.com/narcancer/pa... #NARCancer #CancerResearch #Genomics #Epigenetics

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Nucleic Acids Research @narjournal.bsky.social · 18/03/2026

⭐NAR Breakthrough! ⭐ Back-to-back NAR studies show #Palbociclib binds #HIV TAR RNA with low affinity & striking specificity. Induced-fit RNA refolding creates a #druggable pocket, blocking #SEC recruitment.📖 Read the articles here: doi.org/10.1093/nar/... doi.org/10.1093/nar/... #DrugDiscovery

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Nucleic Acids Research @narjournal.bsky.social · 06/03/2026

⭐ #NARBreakthrough! ⭐ 🧬 New study uncovers how #RNAstructures control stochastic exon selection in Dscam1 genes. #Balancer RNA structures and a #multi-subunit RNA architecture coordinate spatial and temporal splicing 🔬✨ Read the full article here: doi.org/10.1093/nar/... #AlternativeSplicing

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Nucleic Acids Research @narjournal.bsky.social · 04/03/2026

⭐NAR Breakthrough! ⭐ 🧬 New #cryo-EM work shows the #humanINO80 motor adapts to DNA unwrapping and can remodel altered particles like #hexasomes - highlighting its versatility across #nucleosome states. 🔬✨ @lmu.de @genecenter-lmu.bsky.social Read the full article here: doi.org/10.1093/nar/...

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Nucleic Acids Research @narjournal.bsky.social · 02/03/2026

#SpinalMuscularAtrophy (SMA) is treated with the ASO Nusinersen (Spinraza™) to restore SMN via SMN2 splicing. 🧬 New work reveals diverse off-target effects linked to its chemistry—and shows how to mitigate them. 🚀 #NARMolecularMedicine #RNATherapeutics #ASO 🔗 Read here: doi.org/10.1093/narm...

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Davide Seruggia @dseruggia.bsky.social · 26/02/2026

Happy to share our paper in collaboration with cancerbits.bsky.social. We used machine learning & ATAC-seq to refine erythroid differentiation protocols. Recipes for lineage differentiation are written on chromatin! @stanna-ccri.bsky.social @cemm.oeaw.ac.at

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luismontano.bsky.social @luismontano.bsky.social · 26/02/2026

Thank you @narjournal.bsky.social for highlighting and appreciating our most research, a method to find efficient differentiation protocols that make the great cells in the lab with less resources and more insight. Do you want to apply this to your favourite cells? Let's talk!

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Nucleic Acids Research @narjournal.bsky.social · 25/02/2026

⭐ #NARBreakthrough! ⭐ 🔬Using ATAC-seq to measure #chromatin #accessibility, researchers predicted early conditions that would yield successful #differentiation, improve erythroblast production, and identify signals that further boost #efficiency. @stanna-ccri.bsky.social 📖 doi.org/10.1093/nar/...

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Nucleic Acids Research @narjournal.bsky.social · 20/02/2026

🧬 #NARGAB New Research Spotlight Direct #RNA #nanopore sequencing reveals the most detailed #m6A map to date across Human immunodeficiency virus 1 transcripts #HIV-1. @cnrs.fr @i2bcparissaclay.bsky.social 👉 Read the full paper: doi.org/10.1093/narg...

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Nucleic Acids Research @narjournal.bsky.social · 15/02/2026

🔬 New study highlights a novel siRNA polypeptide #nanoparticle targeting TGF β1 and VEGFR2 to overcome ICI resistance in #melanoma. In mice, it cut tumor growth, improved survival, and reduced #metastasis. Read the full article here: doi.org/10.1093/narc... #NARCAncer #Immunotherapy

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Nucleic Acids Research @narjournal.bsky.social · 13/02/2026

🧬 A common ID3 gene variant, rs11574, found in up to 30% of some populations, alters the #ID3protein and disrupts its interaction with E12. ✨ New research shows this change affects gene expression and cell function, offering insight into #diseaserisk. 🔗 Read the paper here: doi.org/10.1093/narm...

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Nucleic Acids Research @narjournal.bsky.social · 12/02/2026

⭐ Explore the NARCAN 5th Anniversary Symposium Collection! 🔬 Featuring exciting work on Polθ, HR, PARP inhibitors, emerging targets, and more! Read here: lnkd.in/ezznFh2f #NARCancer #DNARepair #CancerResearch #TherapeuticTargets #GenomicInstability

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Nucleic Acids Research @narjournal.bsky.social · 12/02/2026

⭐ NARGAB Editor’s Choice: DecoDen integrates multiple epigenomic assays to correct chromatin‑related noise, giving cleaner data and clearer insights. 👉 doi.org/10.1093/narg... #NARGAB #Epigenetics #Genomics #Bioinformatics #PrecisionMedicine

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Nucleic Acids Research @narjournal.bsky.social · 04/02/2026

⭐NAR Breakthrough! ⭐ #RNAtherapeutics show strong promise for #CNSdisorders 🧠. #Preclinical studies reveal that very high doses of #oligonucleotides can cause brief, reversible neuronal activation driven by metal ion interactions 🧪. Read the full article here: doi.org/10.1093/nar/...

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Nucleic Acids Research @narjournal.bsky.social · 21/01/2026

⭐NAR Breakthrough ⭐ New study identifies a 6-nt miR-17 site in the #PKD1 3′UTR that limits PKD1 expression. Targeting this site boosts PKD1 protein and reduces cyst burden in #ADPKD models—highlighting a promising oligo-based strategy @vishal-d-patel.bsky.social 🧬Read more: doi.org/10.1093/nar/...

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Nucleic Acids Research @narjournal.bsky.social · 19/01/2026

⭐NAR Breakthrough! ⭐ 🚀 ALE RNA platform overcomes length limits in #chemicaRNAsynthesis, enabling >200-nt RNAs. Supports sgRNAs and 5′-capped mRNAs with strong translation and precise mods. Site-specific 2′-OMe poly(A) boosts protein expression. 🧬Read more: doi.org/10.1093/nar/... #NARBreakthrough

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Nucleic Acids Research @narjournal.bsky.social · 19/01/2026

🌟 2026 Nucleic Acids Research Database issue 🧬 182 papers, 84 new databases, plus Breakthrough Articles on JoGo (global long‑read haplotypes) and So3D (3D spatial genomics). Browse the issue and Editorial: academic.oup.com/nar/issue/54... academic.oup.com/nar/article/... @danielrigden.bsky.social

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Nucleic Acids Research @narjournal.bsky.social · 23/12/2025

⭐NAR Breakthrough! ⭐ 🔬 #tRNA modifications fine-tune #translation; in yeast, their loss slows #ribosomes at hard-to-read codon pairs, causing collisions ⚠️, and cells deploy quality control pathways to prevent #proteotoxicstress and ensure survival. 🧬Read more: doi.org/10.1093/nar/...

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Nucleic Acids Research @narjournal.bsky.social · 22/12/2025

⭐NAR Breakthrough! ⭐ 🧬 A synthetic RNA forms a #G-quadruplex without a G-rich sequence, using a complex 3D fold and GTP as a ligand. This suggests G-quadruplexes may be far more widespread in biologically important RNAs. Read more: doi.org/10.1093/nar/... #NARBreaktrhough #RNA #StructuralBiology

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Nucleic Acids Research @narjournal.bsky.social · 15/12/2025

🔬 #Trypanosomes process their large rRNA in a highly unusual way-by cutting it into six pieces. A new study from @schneian.bsky.social lab identified two essential proteins, TbLrRP1 and TbLrRP2, that drive this process. Read more: doi.org/10.1093/nar/... #NARBreakthrough #RibosomeBiogenesis

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