Job Description The Department of Biological Sciences in the College of Science at Virginia Tech seeks applicants for two (2) tenure-track research and teaching positions at the Assistant/Associate ...

In this Perspective, Levin and Wang give a brief history of bacterial growth rate and discuss how it is connected to nutrient availability and macromolecule synthesis, with a focus on (p)ppGpp as a ce...

by Hiroshi Nikaido — LB medium, also known incorrectly as Luria-Bertani medium, is widely used to grow bacterial cultures, mainly because it is easy to prepare and provides a broad base of nutrien…

The Department of Biology at UNC Greensboro (UNCG) seeks an individual with a strong record of accomplishment in microbiology broadly defined for a tenure-track faculty position at the rank of Assista...

Staphylococcus aureus divides along sequential orthogonal planes, but the function of this geometry has remained unclear. Ramos-León et al. show that orthogonal division promotes uniform deployment of...

Bacterial ribosomal RNAs (rRNAs) are decorated with conserved nucleotide modifications, but the functionality of these modifications is often underexp…

Staphylococcus aureus divides along sequential orthogonal planes, but the function of this geometry has remained unclear. Ramos-León et al. show that orthogonal division promotes uniform deployment of...

Cell-cell signaling using a core metabolite repurposed as a developmental cue coordinates bacterial multicellular development.

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Oxidative phosphorylation is the most efficient way of generating ATP in respiring cells. As high energy electrons are the major source of reactive oxygen species their production needs to be carefull...

The cell wall peptidoglycan (PG) protects virtually all bacteria from osmotic lysis and specifies cell shape. Synthesis of this exoskeleton is carr...

Using macroevolution, species not strains, uncovered important diversity in how mycobacteria respond to and resist antibiotics, revealing novel resistance determinants.

We write with deep sadness to inform you of the passing of our much-loved colleague, Allison Hillary Mckenzie-Forget Williams, PhD, who died two weeks ago after a years-long battle with cancer. We ext...

Title: Assistant Professor of Biochemistry - Protein Homeostasis Executive Area: Academic Affairs College/School/MBU: College of Natural Sciences Department: Biochemistry/Molecular Biology Work Locati...

by Roberto — With science in stationary phase, I convey a message of hope rather than despair.

INSPIRE is recruiting! Please share broadly with senior graduate students and beginning postdocs. INSPIRE, the NIH-funded Rutgers-IRACDA, offers postdoctoral training for individuals interested in com...

The Department of Molecular Microbiology and Immunology at OHSU invites applications for a tenure-track Assistant or Associate Professor position.

The Erm rRNA methyltransferase superfamily represents the most prevalent determinant of MLS resistance in nosocomial Gram-negative and Gram-positive bacteria. Previous studies have established that erm expression is primarily governed by upstream ribosome stalling peptide and the 5′ untranslated regions. Using the widespread S. aureus ermBL-ermB (ermB+) operon as a model system, we unexpectedly identified second-site mutations in purR that synergistically enhance MLS resistance in an ermB+ background. Loss of purR function derepresses nucleotide biosynthesis and ribosome production, thereby promoting bacterial growth under antibiotic stress. While numerous purR single-nucleotide polymorphisms across multiple species have been associated with antibiotic resistance, no study has directly linked these sequence polymorphisms to their regulatory function. Our results highlight the critical role of ribosome abundance and nucleotide metabolism in shaping antibiotic efficacy.