Multiomic experiments using defined and native gut communities reveal that complex dietary glycans mediate the dominance of Prevotellaceae in non-industrialized gut metagenomes through signalling-medi...

Firmicutes are gram-positive bacteria with important roles in human health, disease, and industry. However, more than a quarter of genes in the mod...

Few journals in microbiology carry the history, continuity, and influence of the Journal of Bacteriology (JB). Since its founding in 1916, JB has published for more than a century and has served as a ...

The patterns and pathways of pathogen adaptation during chronic infections can reveal the gateways microbes must unlock to colonize and persist. In chronic lung infections of cystic fibrosis (CF) pati...

Plasmid construction underpins molecular biology and synthetic biology, yet validation is often limited to the inserted fragment rather than the whole plasmid, and around a third of laboratory-made pl...

Job Description The Department of Biological Sciences in the College of Science at Virginia Tech seeks applicants for two (2) tenure-track research and teaching positions at the Assistant/Associate ...

Applications are invited for an Assistant or Associate Professorship in Pathogen Genetics to be held in the Department of Genetics. We are searching for a talented individual with a track record of fu...

Diet is a key determinant of gut microbial composition and mucosal immune function, yet the microbial mechanisms linking diet-mediated metabolic changes to immune regulation remain incompletely understood. T helper 17 (Th17) cells play central roles in both protective mucosal immunity and inflammatory pathology, making them a critical target of immunometabolic regulation. In this study, we show that 1,3-butanediol (BD) treatment, which leads to elevated circulating β-hydroxybutyrate (BHB) independently of diet, is associated with suppression of intestinal Th17 responses, remodeling of the gut microbiota, and reduced levels of segmented filamentous bacteria (SFB). We further demonstrate that BHB-associated microbiota changes are linked to increased susceptibility to enteric infection. This work provides a mechanistic framework illustrating how metabolic state can influence host immunity through selective effects on commensal microbes. These findings inform future studies of microbiota-mediated immune regulation.

Each autumn the traditional alpabzug (descent of herds) sees farmers in Switzerland move their livestock from mountain pastures down to valley barns. In the Griesalp area above Kiental around 70 alpacas were herded down the valley, before being transported by truck to their winter farm at Aeschi, near Spiez, in the Bernese Oberland

Abstract. Small RNAs (sRNAs) play a crucial role in modulating target gene expression through short base-pairing interactions and serve as integral compone

When used as antibacterial agents, Peptide Nucleic Acid (PNAs) are generally designed to base-pair with complementary sequences of an essential mRNA and block translation initiation. Although bacteria...

Bacterial sRNAs are pervasive post-transcriptional regulators, yet how they arise, evolve, and decay remains poorly understood. Here, we provide a high-resolution transcriptome map and curated sRNA se...

Professor in Medical Bacteriology, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology, Uppsala University

Integron insertion sites engineered into counterselection markers allow large-scale and high-throughput capture of integron-encoded genes from genetically tractable bacteria or DNA samples.

Bacterial ribosomes can synthesize proteins encoded within their own RNA.

Bacterial sRNAs are pervasive post-transcriptional regulators, yet how they arise, evolve, and decay remains poorly understood. Here, we provide a high-resolution transcriptome map and curated sRNA se...

Bacterial ribosomal RNAs (rRNAs) are decorated with conserved nucleotide modifications, but the functionality of these modifications is often underexp…

Ichizawa et al. show that cats maintain durable chemical individuality in urine through donor-specific branched-chain fatty acid (BFA) profiles stabilized by renal cortical lipid droplets. This kidney...

The Faculty of Medicine of the Julius-Maximilians-University of Würzburgand theHelmholtz Institute for RNA-based Infection Research (HIRI, Würzburg)jointly open a call for

Wolfgang R Hess, Kai Papenfort, Cynthia M Sharma, Franz Narberhaus, Ruth A Schmitz; Small proteins in prokaryotes, a fascinating world, microLife, , uqag02