Sign in

Simonetta Gribaldo

@sgribaldo.bsky.social
2K followers 1.1K following 49 posts

Evolutionary microbiologist. Head of lab at Institut Pasteur, Paris. Microbial diversity and evolution. Phylogenomics, Tree of Life, Envelopes, Methanogens. research.pasteur.fr/en/team/evoluti…

PostsRepliesMedia
Reposted by Simonetta Gribaldo
Brett Baker @archaeal.bsky.social · 21h
Two Assistant Professor Positions in Evolutionary Biology and Mechanistic Processes - including microbes! faculty.utexas.edu/career/191568
faculty.utexas.edu
Faculty Careers - The University of Texas at Austin
Unleash your intellectual power by joining a world-renowned faculty that is solving the world's most urgent problems. At UT Austin, we provide you the freedom to blaze trails, follow your curiosity, e...
02736
Reposted by Simonetta Gribaldo
Institut Jacques Monod @ijmonod.bsky.social · 01/10/2026
✍️ The Bonazzi Lab published a new article 📖 @natcomms.nature.com 📃Bacterial growth under confinement requires transcriptional adaptation to resist turgor pressure build-up 🔗 www.nature.com/articles/s41...
1106
Reposted by Simonetta Gribaldo
Archaea Biology Vienna @archaea-vienna.bsky.social · 01/10/2026
Our paper on the dynamics of Asgard archaea (Promethearchaeota) is now out in Nature! Huge thanks to the reviewers for helping make the manuscript stronger. www.nature.com/articles/s41... Two “Lokis” stained for Lokiactin (FastAct, magenta), reaching toward each other to celebrate 🎉 #archaea
413447
Reposted by Simonetta Gribaldo
Cameron Thrash @jcamthrash.bsky.social · 30/09/2026
Dynamic protrusions mediate crawling motility in Asgard archaea www.nature.com/articles/s41... #jcampubs
nature.com
Dynamic protrusions mediate crawling motility in Asgard archaea - Nature
Anoxic live-cell imaging shows actin-dependent crawling motility and dynamic protrusions in Asgard archaea, providing insights into cellular innovations that may have contributed to eukaryotic evoluti...
02810
Reposted by Simonetta Gribaldo
Olivera Francetic @oliverafr.bsky.social · 27/09/2026
Learn about Tom's amazing legacy and inspiring contributions to science and education. mSphere Legacy: A career built on suppressors | mSphere journals.asm.org/doi/10.1128/...
journals.asm.org
mSphere Legacy: A career built on suppressors | mSphere
I grew up in a small town, Wauseon, in the northwest corner of Ohio. Although I enjoyed science and math classes in high school, a career in research and academia never crossed my mind. I worked for s...
062
Reposted by Simonetta Gribaldo
Javier del Campo @fonamental.bsky.social · 23/09/2026
A genomic catalog of Earth’s bacterial and archaeal symbionts #symbiosis www.nature.com/articles/s41...
nature.com
A genomic catalog of Earth’s bacterial and archaeal symbionts - Nature Biotechnology
Symbiotic relationships of microorganisms are predicted and cataloged with a machine learning tool.
03516
Reposted by Simonetta Gribaldo
Anthony Vecchiarelli @cellforganized.bsky.social · 19/09/2026
Applications are now being accepted for the 2027 Bacterial Cell Biology & Development GRC, June 6–11! GRS will be on June 5-6, 2027 We’ll likely be oversubscribed, so please apply early!
26638
Reposted by Simonetta Gribaldo
Nika Pende @nikapende.bsky.social · 23/09/2026
So happy to see this paper finally out 🥳 it took only seven years after the first purification of archaeal peptidoglycan 🤣 Congrats to all the people involved 🥂🍾 And here is the story behind the paper: communities.springernature.com/posts/cracki...
communities.springernature.com
Cracking the Archaeal Cell Wall: How a hydrolase overturned a 50-year-old paradigm
Using bioinformatics, biochemistry, NMR, as well as the newly characterized enzyme ArmA from methanogenic archaea, we revised the existing knowledge on archaeal peptidoglycan structure. At the same ti...
95218
Simonetta Gribaldo @sgribaldo.bsky.social · 23/09/2026
Interested in #archaea, #methane, #cell-envelopes? New paper out @nature.com ! We discovered an enzyme that specifically cleaves the cell wall of methanogens, revealing a new chemical structure of archaeal peptidoglycan, 50 yrs after its first description www.nature.com/articles/s41... #MicroSky 🧵👇
nature.com
1512578
Reposted by Simonetta Gribaldo
Buzz Baum @buzzbaum.bsky.social · 22/09/2026
We are looking for a research assistant! Come join the team: www.jobs.ac.uk/job/DSZ826/r...
jobs.ac.uk
Research Support Officer | Cell Biology | Dr Buzz Baum | LMB 2904 at MRC Laboratory of Molecular Biology
Start your UK & international job search for academic jobs, research jobs, science jobs and managerial jobs in leading universities and top...
02846
Reposted by Simonetta Gribaldo
Christophe Zimmer @chzimmer.bsky.social · 10/09/2026
Can you tell how an antibiotic kills bacteria just by watching them under a regular microscope — without any dyes ? Yes, it turns out, at least if you are a deep neural net.
12316
Reposted by Simonetta Gribaldo
Evgenii Protasov @evgenii-protasov.bsky.social · 10/09/2026
The structure of a nitrogenase from a hyperthermophilic methanogen growing at 92 °C sheds light on how nitrogen fixation evolved 🧫🔥 #Microbiology #Methanogens #StructuralBiology #Evolution #Nitrogenase #MicroSky #ArchaeaSky @natcomms.nature.com doi.org/10.1038/s414...
doi.org
Molecular basis of N2 fixation in a hyperthermophilic archaeon - Nature Communications
Nitrogenases are enzymes that convert atmospheric N2 into ammonia, thus providing bioavailable nitrogen to living organisms. Here, Maslać et al. describe a highly thermostable, simple nitrogenase from...
0177
Reposted by Simonetta Gribaldo
Julian Parkhill @julianparkhill.bsky.social · 08/09/2026
Chair in Bacteriology in Cambridge Department of Medicine. A great opportunity. Please circulate. www.cam.ac.uk/jobs/researc...
cam.ac.uk
Research Professor in the field of Bacteriology
Strengthening Cambridge's leadership in bacteriology research Bacterial infection and antimicrobial resistance remain among the most pressing global health challenges of our time. At Cambridge, the De...
02459
Simonetta Gribaldo @sgribaldo.bsky.social · 25/08/2026
Exceptional lineup and venue, already registered 😉 👇👇👇
032
Reposted by Simonetta Gribaldo
EMBO @embo.org · 24/08/2026
Sign up now for the EMBO Workshop "Bacterial and archaeal #CellDivision: Diverse mechanisms and models" in Barga (Lucca), Italy, 20–23 April 2027. Deadline: 6 January 2027 meetings.embo.org/event/27-cell-div… #EMBObacDiv27 #genetics #biochemistry #StructuralBiology #EMBOevents 🧪
22015
Reposted by Simonetta Gribaldo
Tobias Warnecke @tobiaswarnecke.bsky.social · 22/08/2026
Who needs chromatin anyway...? NOT THIS GUY! www.biorxiv.org/content/10.6... 1/n
biorxiv.org
Chromatin is dispensable for bacterial life
Inside cells, DNA is intimately associated with proteins, forming chromatin. The protein constituents of chromatin vary across the tree of life: histones are the principal building blocks of chromatin...
3231104
Reposted by Simonetta Gribaldo
Cell Reports @cp-cellreports.bsky.social · 26/07/2026
Outer membrane remodeling via lipid-peptidoglycan crosstalk enables lipooligosaccharide-deficient colistin resistance
dlvr.it
Outer membrane remodeling via lipid-peptidoglycan crosstalk enables lipooligosaccharide-deficient colistin resistance
Olea-Ozuna et al. show that outer membrane lipid asymmetry acts as a checkpoint controlling lipooligosaccharide-independent survival in Acinetobacter baumannii. Disrupting phospholipid homeostasis creates a permissive state enabling LOS loss under colistin selection, while reduced PBP1A activity stabilizes this transition, defining a three-state model of envelope remodeling and resistance.
093
Reposted by Simonetta Gribaldo
bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 25/07/2026
Intrafilament nucleotide exchange in a prokaryotic actin homolog www.biorxiv.org/content/10.64898/20…
086
Reposted by Simonetta Gribaldo
Juan Martin Serrano @juanmartin-serrano.bsky.social · 15/07/2026
Very proud to see this paper out. This is an incredible collaboration with the labs of Wes Sundquist and Adam Frost. @uofubiochem.bsky.social @kingslsm.bsky.social www.nature.com/articles/s41...
nature.com
ESCRT-III assembles around mis-segregated DNA to protect genome stability - Nature Structural & Molecular Biology
The authors show that persistent ultrafine DNA bridges become coated by membranes and the ESCRT-III proteins CHMP1B and IST1, which protect the genome within from damage.
53819
Reposted by Simonetta Gribaldo
Structural Biology and Chemistry Dpt - Institut Pasteur @ipdbsc.bsky.social · 15/07/2026
Job Opportunity: #CNRS Chemistry - #InstitutPasteur Mid-Career Group Leader (Chemistry for Health) is open in Paris, France. This is a fantastic opportunity for a standout chemist to establish themselves in a world-class environment. research.pasteur.fr/en/call/mid-...
research.pasteur.fr
Mid-career Group Leader position in Chemistry for Health at Institut Pasteur, Paris - Research
Institut Pasteur and the CNRS are launching a joint call for a mid-career group leader position in Medicinal Chemistry and Chemistry for Health. We are looking for an experienced researcher (typically...
048
Reposted by Simonetta Gribaldo
Jutras Lab @jutraslab.bsky.social · 15/07/2026
We're hiring an enthusiastic and ambitious technician to unravel the mysteries of spirochetes (#Lyme #syphilis). Come be a part of a wonderful team and working enviro in beautiful Chicago! Looking for training micro, molec, cell, or glycobiology of pathogens?👇 myhr.northwestern.edu/psp/hrnu/EMP...
#Microsky
052
Reposted by Simonetta Gribaldo
Iñaki Ruiz-Trillo @multicellgenome.bsky.social · 15/07/2026
Most people have never heard of #apusomonads. Yet these tiny protists occupy an important position in the eukaryotic tree of life. And we know so little about them! We're looking for a Master's student to help uncover their hidden diversity. #ProtistsOnSky 🧵 @ibe-barcelona.bsky.social @prbb.org
2319
Reposted by Simonetta Gribaldo
Rafal Mostowy @rafalmostowy.bsky.social · 15/07/2026
PhD opening in my lab @jagiellonskiuni.bsky.social: using AI to predict how phage enzymes break down bacterial capsules — joint work with ML group GMUM and Zuzanna Drulis-Kawa's phage lab (Wrocław), spanning genomics, AI & evolution. mostowylab.com/job-phd-ai-d... Deadline: 15 August 2026
11016
Simonetta Gribaldo @sgribaldo.bsky.social · 15/07/2026
Looks fantastic indeed and sorry I couldn't come! But check out for @babebe.bsky.social (talk tomorrow) and @annakurowska.bsky.social (poster) who are egregiously representing the lab ;-) #envelope #evolution #monoderm-diderm-transition
020
Reposted by Simonetta Gribaldo
Osterman Ilya @ostermanilya.bsky.social · 13/07/2026
🚨 We're hiring! My new lab at EMBL Hamburg is looking for a Research Technician. I'm looking for someone excited by phages, metabolism, enzymes, structural biology and bacterial immunity—if you know the right person, please share this post!🧵⬇️ Apply here: embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
embl.wd103.myworkdayjobs.com
Research Technician (Osterman Group – Metabolism-driven immunity)
EMBL Hamburg / CSSB The European Molecular Biology Laboratory (EMBL) is Europe’s flagship life sciences organization, with more than 110 independent research groups across Heidelberg, Hamburg, Grenobl...
32940
Reposted by Simonetta Gribaldo
Katherine Fenn @katherinefenn.bsky.social · 10/07/2026
Read our new paper! We show how the protease BepA binds the BAM complex and undergoes striking conformational changes, embedding its water-soluble lid into the membrane to cleave outer membrane proteins. www.nature.com/articles/s41... #cryoEM #astburycentre
22814
Reposted by Simonetta Gribaldo
Rafal Mostowy @rafalmostowy.bsky.social · 10/07/2026
Klebsiella phages often modify the bacterial capsule instead of degrading it, stripping acetyl groups. Nobody's traced how this evolves. I'm hiring a computational postdoc to find out — Kraków, apply by 21 July. mostowylab.com/job-postdoc-...
11410
Reposted by Simonetta Gribaldo
Gregor Weiss @weiss-lab.bsky.social · 10/07/2026
Some bacteria do not live as individuals. They build multicellular filaments and connect neighboring cells through tiny cell-cell junctions. Cyanobacteria are among the most beautiful examples 😍 In our new paper, we reveal first molecuar insights on the cyanobacterial septal junction architecture 🧵
311527
Reposted by Simonetta Gribaldo
Georgia Isom @georgiaisom.bsky.social · 10/07/2026
Interested in joining our group in Oxford? We are looking for a PDRA with single particle Cryo-EM experience to help us figure out how sphingolipids are transported to the cell surface of Gram-negative bacteria. The deadline is 31st July. Informal enquires are welcome. Please share!
my.corehr.com
Job Details
12124
Reposted by Simonetta Gribaldo
Géraldine Laloux @lalouxlab.bsky.social · 09/07/2026
New preprint! We show that the bacterial predator B. bacteriovorus deploys a unipolar Tad nanomachine for irreversible attachment to prey and invasion. @coralietesseur.bsky.social used CRISPRi+microfluidics to overcome barriers associated with essential systems in an obligate predatory lifestyle 🦠
biorxiv.org
A polarity-controlled Tad nanomachine enables prey invasion in a bacterial predator
Type IV pili are dynamic surface appendages assembled by envelope-spanning nanomachines that mediate diverse bacterial interactions, yet how these systems are adapted to predatory lifestyles remains p...
24717
Reposted by Simonetta Gribaldo
Chung Hyun Cho @chc-evobio.bsky.social · 04/07/2026
Excited to share our new preprint led by Fred and me in collaboration with the archaeal community! We found that the molecular foundation of histone-based chromatin has pre-eukaryotic roots in Asgard archaea. (1/4) #ArchaeaSky www.biorxiv.org/content/10.6...
biorxiv.org
Emergence of histone-based chromatin complexity in Asgard archaea
The emergence of the eukaryotes coincided with the diversification of histone proteins and their post-translational modifications by enzymes that constitute the core of eukaryotic chromatin. Yet the e...
814676
Reposted by Simonetta Gribaldo
Paula Navarro @navarropaula.bsky.social · 03/07/2026
🚨 New in @natmicrobiol.nature.com! We reveal how the antibiotic target PBP1b fortifies the E.coli division site against osmotic rupture. Proud this was completed in our independent labs @dmf-unil.bsky.social, with @avettiger.bsky.social. Congratulations to all authors! 🦠❄️🔬 #teamtomo bit.ly/3SCbOg1 👇
doi.org
The penicillin-binding protein PBP1b fortifies the Escherichia coli division site against osmotic rupture - Nature Microbiology
A specific isoform of PBP1b functions independently of the activator protein, LpoB, to drive generation of a wedge-like peptidoglycan structure that strengthens the division site in Escherichia coli.
39333
Reposted by Simonetta Gribaldo
Nancy Moran @nancy-moran.bsky.social · 02/07/2026
A step forward in discovering Buchnera's key to the aphid's heart, published today! Thanks to Jerry Maeda and other authors--a great team -- and to the helpful reviewers #SymbioSky doi: doi.org/10.1038/s415...
doi.org
A secreted endosymbiont protein essential for colonizing host cells - Nature
SyeA was present in the Buchnera ancestor, is secreted into the host cytoplasm, is homologous to secreted effectors of bacterial pathogens and is essential for Buchnera transmission.
210541
Reposted by Simonetta Gribaldo
Harmit Singh Malik @harmitmalik.bsky.social · 01/07/2026
Jeremy Hollis’ detective story on centromeric histone chaperones (HJURP/Cal1) is now published after peer review with a few extra goodies. @jeremyahollis.bsky.social @nlehrbach.bsky.social @cbmoens.bsky.social @irinakitop.bsky.social @basicsci.fredhutch.org www.science.org/doi/10.1126/...
science.org
Remote homology and functional genetics unmask deeply preserved Scm3/HJURP orthologs in metazoans
Animals encode a rapidly evolving, essential cell cycle gene previously thought to be absent.
23012
Reposted by Simonetta Gribaldo
Andrew Roger @andrewjroger.bsky.social · 19/06/2026
1/ Deep-time phylogenetics is hard: overly simplistic substitution models can mislead tree estimation at the billion year timescale. Our new preprint introduces GTRspmix, a protein modeling framework designed to more realistically model site-to-site heterogeneity in amino acid replacement. 🧵
15221
Reposted by Simonetta Gribaldo
Svetlana Dodonova @dodonova-sveta.bsky.social · 19/06/2026
Excited to share our new preprint! 🧬❄️ by brilliant @mdreimann.bsky.social and great collaborators! Using cryo-ET&EM, we reveal archaeal chromatin in a near-native state: variable-beads-on-a-string fibers shaped by growth phase and histone composition #ArchaeaSky www.biorxiv.org/content/10.6...
815363
Reposted by Simonetta Gribaldo
Christophe Zimmer @chzimmer.bsky.social · 18/06/2026
Open postdoc position in the Imaging and Modeling Unit at Institut Pasteur, in collaboration with Mickaël Cohen of IBPC (Paris, France). High-throughput imaging and deep learning to analyze mitochondrial morphology and understand genetic bases of cellular respiration. Please spread the word.
postdoc position at Institut Pasteur and IBPC to work on mitochondrial morphology using advanced imaging and deep learning
01413
Reposted by Simonetta Gribaldo
Kranzusch Lab @kranzuschlab.bsky.social · 12/06/2026
How do human cells defend against viruses? @sgfern.bsky.social discovers that human immune proteins named ISGs target ancient features of replication shared between animal and bacterial viruses – opening analysis of human immunity to the power of bacterial genetics www.biorxiv.org/content/10.6...
311565
Reposted by Simonetta Gribaldo
Debnath Ghosal @debnathghosal.bsky.social · 12/06/2026
New paper alert!! We just discovered a new filament system that is widespread exclusively within CPR bacteria! www.biorxiv.org/content/10.6.... Short thread below. 🦠🔬🚀
biorxiv.org
A Novel Pilus System in Candidate Phyla Radiation Bacteria
The Candidate Phyla Radiation (CPR) represents a bacterial superphylum estimated to include between 15–50% of all bacterial species, yet CPR bacteria remain challenging to culture and have been primar...
25525
Reposted by Simonetta Gribaldo
Tobias Warnecke @tobiaswarnecke.bsky.social · 11/06/2026
Archaea the hornets of the microbial world. Discuss. www.biorxiv.org/content/10.6... TLDR: Archaeon kills bacterium with secreted phospholipase. Pretty nifty way to kill bacteria if you are a microbe with a very different lipid make-up, I reckon. No need to worry about accidentally killing yourself.
biorxiv.org
A Bactericidal Phospholipase from Archaea
Archaea kill bacteria, at least on occasion. The molecular underpinnings of these lethal interactions are barely understood. Here, we describe cinquedea, an α/β hydrolase secreted by the halophilic ar...
14416
Reposted by Simonetta Gribaldo
Geoff McFadden @fad1.bsky.social · 07/06/2026
Today marks 30 years since we identified the apicoplast, a relict plastid in human and animal parasites (PMID 8632819). Apicoplasts are the target of the widely used antimalarial prophylactic doxycycline, which has saved many thousands of malaria infections.
37932
Reposted by Simonetta Gribaldo
Harmit Singh Malik @harmitmalik.bsky.social · 04/06/2026
There are two types of people in the world: those who discovered Persepolis and were richer for the experience, and those that still have to. RIP Marjane Satrapi. www.lemonde.fr/en/obituarie...
lemonde.fr
Marjane Satrapi, author of 'Persepolis,' dies at 56
The French-Iranian artist and film director 'died of sadness a little over a year after the death of Mattias Ripa, her husband and the love of her life,' people close to her said.
24711
Reposted by Simonetta Gribaldo
Liz Cooney @protistwtmostest.bsky.social · 25/05/2026
We are looking for candidates to fill a PhD position in Grenoble, France. Please share with anyone interested in microbial symbioses! #dinoflagellate #symbiosis www.linkedin.com/posts/johan-...
linkedin.com
PhD position available in the team (Cell and Plant Physiology Lab) in Grenoble, in close collaboration with Prof Patrick Keeling from Univ. of British Columbia (Canada), Liz Cooney (Photosymbiosis… | ...
PhD position available in the team (Cell and Plant Physiology Lab) in Grenoble, in close collaboration with Prof Patrick Keeling from Univ. of British Columbia (Canada), Liz Cooney (Photosymbiosis tea...
0911
Reposted by Simonetta Gribaldo
Aude Bernheim @audeber.bsky.social · 22/05/2026
Great piece and cover @science.org about how our field is uncovering the evolutionary and mechanistic connections between bacterial and eukaryotic immunity ! www.science.org/content/article/ancient-wars-between-microbes-gave-us-key-immune-defenses
49330
Reposted by Simonetta Gribaldo
Daniel Tamarit @danieltamarit.bsky.social · 22/05/2026
I'm looking for an enthusiastic student to join my team as a PhD candidate on archaeal genome evolution 🦠💻 Work in beautiful Utrecht, at @binfutrecht.bsky.social, an international group full of caring, amazing scientists, and with frequent cake breaks! www.uu.nl/en/organisat... Please share! 🙏
uu.nl
06371
Reposted by Simonetta Gribaldo
Leigh Anne Riedman @fossils.bsky.social · 20/05/2026
Excited to say that my new paper with @maxlechte.bsky.social (and others not on bluesky) has come out in @nature.com! Study of sediments, geochemistry and fossils from rocks 1.75 to 1.4 billion years old indicate that the oldest known #eukaryotes were aerobic and benthic! #protists rdcu.be/fjNgL
rdcu.be
Early fossil eukaryotes were benthic aerobes
Nature - Integrated palaeontological, sedimentological and geochemical analyses of ancient rocks from Australia show that early eukaryotes were largely restricted to oxygenated benthic habitats,...
410243
Reposted by Simonetta Gribaldo
Max Lechte @maxlechte.bsky.social · 21/05/2026
The innovation of the eukaryotic cell revolutionised the biosphere & transformed the planet, but the drivers behind this process remain debated. New paper out @natureportfolio.nature.com co-led by @fossils.bsky.social w/ Susannah Porter, Galen Halverson & Maggie Whelan @mcgillscience.bsky.social 🌎
Eukaryote microfossils from the Palaeoproterozoic. Credit: Leigh Anne RiedmanRock cores of a Palaeoproterozoic sedimentary succession at the Northern Territory Geological Survey. Credit: M Lechte
1258
Reposted by Simonetta Gribaldo
Sonja-Verena Albers @archaellum.bsky.social · 20/05/2026
New preprint! Cell division has to happen at the right place but how Archaea pick that place is unknown. We now identified a three-protein system, Dip, that positions the divisome at midcell in H. volcanii and is broadly conserved across Archaea. A thread 🧵 www.biorxiv.org/content/10.6...
biorxiv.org
911252
Reposted by Simonetta Gribaldo
Philippe Bastin's Lab @bastinlab.bsky.social · 18/05/2026
Flagella can be assembled by IFT without the canonical heterotrimeric kinesin! Grab a cup of tea or coffee and follow a story that started 25 years ago
1137
Reposted by Simonetta Gribaldo
Luisa De Sordi @luisadesordi.bsky.social · 18/05/2026
I had fun writing a short commentary on the importance of integrating prophage biology into microbiome research 🦠 Now out in @cp-cellhostmicrobe.bsky.social #microbiomesky #phagesky www.cell.com/cell-host-mi...
cell.com
Making room for gut prophages in human health
Prophages are pervasive in the human gut yet largely overlooked in microbiome research, despite substantial functional potential. Emerging evidence indicates that prophages regulate bacterial fitness,...
01914