Transposable elements mobilize within and occasionally between genomes, including from host to virus. We identified two insertions of the human BC200 noncoding RNA gene in the poxvirus molluscum conta...

In memoriam: Professor Timothy H. Bestor 1952-2026

An exciting postdoctoral position is available to research the role of epigenetic marks in gene regulation.

The genomic regions regulating gene expression are often themselves transcribed into a variety of noncoding RNAs (ncRNAs). However, the regulatory roles of this noncoding transcription remain largely ...

Activation-induced cytidine deaminase (AID) accomplishes somatic hypermutation (SHM) of V_H(D)J_H genes in germinal center B cells for antibody diversification and affinity maturation. How AID specifically targets V_H(D)J_H remains unclear. We report the disco …

Activation-induced cytidine deaminase (AID) accomplishes somatic hypermutation (SHM) of V_H(D)J_H genes in germinal center B cells for antibody diversification and affinity maturation. How AID specifically targets V_H(D)J_H remains unclear. We report the disco …

A postdoctoral scholarship within the project “Transposable elements and the aging human brain: Functional Insights and therapeutic opportunities”

A longstanding mystery in antibody diversification is how AID specifically targets immunoglobulin V genes. Ancient LINE-1 retrotransposons embedded within the immunoglobulin locus provide a recruitment platform for the HUSH complex and AID to drive somatic hypermutation.

X-chromosome inactivation (XCI) enables gene dosage compensation in XX eutherians. Long interspersed element-1 (LINE-1 or L1) retrotransposons are unusually abundant on the human X chromosome and are ...

Preferential insertion into the late-replicating inactive X explains L1 accumulation in this chromosome

X-chromosome inactivation (XCI) enables gene dosage compensation in XX eutherians. Long interspersed element-1 (LINE-1 or L1) retrotransposons are unusually abundant on the human X chromosome and are ...

In Metazoa, transposon expression is suppressed by the piRNA pathway, and disruption of this pathway leads to rampant transposon expression. However, it remains unclear whether increased transposon ex...

X-chromosome inactivation balances X-gene dosage between the sexes in eutherians and marsupials. The lncRNA Xist mediates X-inactivation in eutherians but is absent from marsupials. An evolutionarily ...

The eORFeome, a large-scale collection of open reading frames encoding viral proteins and secreted bacterial and parasite effectors, enables functional genomics across diverse pathways and pathogens. ...

Biochemical, structural and cell biological analyses reveal that UAP56 (DDX39B) assembles with a TREX-2–like module that redirects non-functional polyadenylated RNAs from export to degradati...

06-07 July 2026 | Munich, GermanyDNA Replication and Its Impact on Genome and Chromatin MaintenanceWe are RepliFate, a European Training Doctoral Network dedicated to understanding how DNA replication...

Researchers say securing funding has become increasingly tough, with many left with no choice but to spend a disproportionate amount of time applying for grants.

Some proteins mimic the repressive mark H3K27me3, but the physiological relevance of this phenomenon was unclear. Agius et al. show that the PRC2 subunits JARID2 and PALI1 mimic H3K27me3 to antagonize...

Neville, Ferguson et al. show that non-canonical Polycomb repressive complex 1.1-mediated gene silencing is antagonized by DOT1L and is required for the therapeutic efficacy of Menin and DOT1L inhibit...

Nature has retracted a paper after an investigation at a U.K. institution found the first author — then a doctoral student — manipulated data.  The paper, which looked at the sensitivity of lu…