Preferential insertion into the late-replicating inactive X explains L1 accumulation in this chromosome

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Viruses, bacteria, and other pathogens pose a serious threat to human health, requiring a coordinated response from the innate and adaptive immune systems. Our immune system relies on pathogen recept…

DNA methylation loss at transposable elements (TEs) can affect neighboring genes and be epigenetically inherited in plants, yet the determinants and significance of this additional system of inheritan...

Retrotransposons are mobile repetitive elements that constitute around 43% of the human genome. Normally silenced through epigenetic mechanisms, retrotransposons can become reactivated in response to ...

Group II Introns (G2Is) are large self-splicing ribozymes with promising biotechnological applications. This study utilized RNA inverse folding to design three novel G2Is. The designed intron Arq.I2,...

Transposable elements (TEs) make up the bulk of eukaryotic genomes and examples abound of TE-derived sequences repurposed for organismal function. ...

Each year on DNA Day, we celebrate the DNA double helix structure and the Human Genome Project's completion. Here we dive into a fascinating genomic component: transposable elements. Once seen as mere...

Nature Structural & Molecular Biology - Here the authors show that the disruption of OGT expression in mouse embryonic stem cells unleashes TET activity, causing genome-wide decreases in DNA...

Abstract. The 22q11.2 deletion syndrome (22qDS) is a human disorder where the majority of clinical manifestations originate during embryonic development. 2

Le vieillissement entraîne une accumulation de cellules sénescentes qui échappent au système immunitaire et contribuent à des maladies chroniques telles que l

Transposable element exonization can yield functional protein isoforms as seen for primate-specific IFNAR2.

Les éléments transposables, également connus sous le nom de « gènes sauteurs », sont des séquences d’ADN capables de se répliquer dans notre génome. Très abondants, répétés et dispersés, ils sont main...