The EMBO Journal -

The activation of the embryonic genome is a crucial step in development. In addition to thousands of genes, many transposable elements (TEs) are robustly transcribed during early mammalian development...

Greg was already a world-renowned scientist when appointed Director, and for the community, he was a visionary leader, a cherished mentor, and a singular force of nature whose influence shaped the research landscape.

STING is an evolutionarily conserved key regulator of innate immunity. In the model organism Drosophila melanogaster, STING activates the NF-κB-like transcription factor Relish, initially characterize...

The roles of the piRNA pathway in human oocytes are poorly understood. Here, the authors profile small and long RNAs in single oocytes and show that short piRNAs broadly repress transposable elements,...

Targeting chromatin modifiers to DNA hotspots reveals causal link between histone marks, transcription, and meiotic recombination.

Background The role of transposable elements (TEs) in host adaptation has gained interest in recent years. Individuals of the same species undergo independent TE insertions, providing genetic variabil...

This study highlights that Schlafens are ancient, mechanistically conserved immune effectors that mediate antiviral immunity in organisms ranging from humans to bacteria.

First competitive call open! The first competitive call in the frame of the MuSkLE programme, which aims at selecting 17 doctoral fellows, opens on 6th March 2026 and closes on 6th May 2026. The open ...

Researchers summarize key insights from the world’s first comprehensive investigation into how a pandemic started.

Transposable elements (TEs) make up about half of the human and mouse genomes and play important regulatory roles in immune responses. However, the cis -regulatory contribution of TEs to immune cell d...

La recherche de Leandro Quadrana combine des approches de génétique moléculaire, de génomique des populations et de biologie computationnelle pour comprendre comment les éléments transposables façonnent les génomes et l’adaptation des organismes. Après une thèse (2008-2013) réalisée à l’Université de Buenos Aires, il rejoint l’équipe de Vincent Colot à l’Institut de biologie de l’École normale supérieure à Paris comme chercheur post-doctoral, où il étudie le contrôle épigénétique des éléments transposables. Recruté au CNRS en tant que chargé de recherche en 2017, il crée et dirige depuis 2021 l’équipe « Génomique et épigénomique des plantes » au sein de l’Institut de sciences des plantes de Paris-Saclay - IPS2 (CNRS/Université Paris-Saclay). Grâce au programme Momentum du CNRS et une ERC Starting Grant, son équipe a mis en place des approches expérimentales et bio-informatiques pour suivre l’activité des éléments transposables dans des populations entières de plantes et en réponse aux changements environnementaux. Ses travaux ont été récompensés par la médaille de bronze du CNRS en 2021 et ont contribué à positionner son équipe comme un acteur majeur de l’étude des « gènes sauteurs » chez les plantes.

JASPAR is the largest open-access database of curated and non-redundant transcription factor (TF) binding profiles from six different taxonomic groups.

Endogenous retroviruses (ERV) represent 8 to 10% of mammalian genome. While most ERV are defective, a few retroviral genes, such as the envelope syncytins, were exapted during evolution and likely contributed to the emergence of placental mammals. We have previously identified the oldest full-length …

Endogenous retroviruses (ERV) represent 8 to 10% of mammalian genome. While most ERV are defective, a few retroviral genes, such as the envelope syncytins, were exapted during evolution and likely contributed to the emergence of placental mammals. We have previously identified the oldest full-length …

Background. Paramecia belong to the ciliate phylum of unicellular eukaryotes characterized by nuclear dimorphism. A diploid germline micronucleus (MIC) transmits genetic information across sexual gene...

imageimageProtein and peptide tags can profoundly alter condensation in a tag- and protein-specific manner, both in cells and in vitro, highlighting the need for careful validation in condensate studi...

Transposons are parasitic nucleic acids present in most genomes. The ability of transposons to mobilize makes them a source of genetic diversity and a threat to genome integrity. Interestingly, mutati...

### Competing Interest Statement The authors have declared no competing interest. Agriculture and Agri-Food Canada, https://ror.org/051dzs374 Alberta Grain Saskatchewan Wheat Development Commissio...

Long-read sequencing in 18 unicellular eukaryotes reveals that 6mA is widespread across eukaryotes and is enriched at transcriptionally permissive regions, which are also marked by H3K4me3.

Certain genes, chromosomes, organelles, or entire sets of chromosomes can bias their transmission to the next generation, propagating themselves at the expense of the rest of the genome. Referred to …