dlvr.it
DNA bendability inside the nucleosome regulates INO80’s nucleosome positioning
Shukla et al. find that the INO80 chromatin remodeler positions nucleosomes at specific genomic positions, including the 5′ end of genes. INO80 recognizes DNA shape rather than a unique DNA sequence. Nucleosome movement is blocked when INO80 encounters inflexible DNA inside the nucleosome, mediated by the DNA-rigidity-sensitive binding of its Arp5 subunit.