Nature Reviews Genetics, Published online: 28 September 2026; doi:10.1038/s41576-026-01022-5In this Journal Club, Kamila Naxerova reflects on two landmark studies by Knouse et al. and Davoli et al. that helped explain how disrupted epithelial tissue architecture promotes aneuploidy and why particular patterns of chromosome gain and loss recur across cancers.

Scientists uncover thousands of previously missed proteins, many of which appear to be relevant to human health — including promising new targets for cancer immunotherapies.

Author summary Spatial transcriptomics (ST) lets researchers measure gene expression while preserving the tissue location of each measurement. Where a cell sits, and which cells surround it, shape how...

Nature Reviews Cancer, Published online: 15 September 2026; doi:10.1038/s41568-026-00977-1Viral mimicry is the activation of antiviral immune responses by endogenous nucleic acids that have accumulated in the cytosol. In this Review, Chen et al. highlight how cancer-associated epigenetic and transcriptional dysregulation promotes the generation of immunogenic nucleic acids, which can limit tumour progression. They further outline the mechanisms tumours use to suppress these responses, and the evidence that escape from viral mimicry is central to tumour evolution and a potential target for therapy.

The genomic regions regulating gene expression are often themselves transcribed into a variety of noncoding RNAs (ncRNAs). However, the regulatory roles of this noncoding transcription remain largely ...

The genomic regions regulating gene expression are often themselves transcribed into a variety of noncoding RNAs (ncRNAs). However, the regulatory roles of this noncoding transcription remain largely unknown. By using live imaging, we reveal that the ...

Over the course of a lifetime, somatic mutations accrue in normal human cells, causing variation in cell phenotype and engendering somatic evolution with outcomes ranging from the adaptive immune syst...

Nature Reviews Gastroenterology & Hepatology, Published online: 01 September 2026; doi:10.1038/s41575-026-01243-3Long non-coding RNAs (lncRNAs) are emerging as key regulators in cancer progression, including colorectal cancer (CRC). This Review provides a mechanistic overview of the role of lncRNAs in the CRC microenvironment and discusses their potential in precision oncology.

Nature Reviews Gastroenterology & Hepatology, Published online: 01 September 2026; doi:10.1038/s41575-026-01243-3Long non-coding RNAs (lncRNAs) are emerging as key regulators in cancer progression, including colorectal cancer (CRC). This Review provides a mechanistic overview of the role of lncRNAs in the CRC microenvironment and discusses their potential in precision oncology.

From geometric intelligence to cardiac network models, recordings of talks from recent speakers at the UVA School of Data Science

Unmeasured confounding threatens causal inference and replicability in observational multi-omic studies across variable environments. Genetic instrumental variables (Mendelian randomization) and negat...

Suppressor transfer RNAs (sup-tRNAs) can rescue disease-causing nonsense mutations by promoting readthrough of premature termination codons (PTCs). Their clinical translation is limited by suboptimal ...

The experimental validation of fundamental thought experiments in quantum mechanics has profoundly advanced quantum science and technology while deepening our understanding of quantum mechanics. Howev...

AbstractBackground:. Red meat consumption is a risk factor for colorectal cancer and has been linked to tumor alkylating DNA damage. rs16906252-T is a cis expression quantitative trait locus variant a...

Nature Reviews Cancer, Published online: 25 August 2026; doi:10.1038/s41568-026-00969-1In this Review, Franceschini and colleagues discuss how remodelling of the 3D structure of chromatin in cancer is both a cause and a consequence of genetic and epigenetic alterations and highlight how chromatin 3D conformation might be exploited for diagnosis and therapy.

Nature Reviews Cancer, Published online: 19 August 2026; doi:10.1038/s41568-026-00972-6In this Journal Club, Sandra Romero-Cordoba discusses a study that identifies a replication-associated DNA methylation signature, termed CellDRIFT, providing evidence that epigenetic drift linked to cell division may contribute to oncogenic transformation.

Alternate RNA decoding, an understudied process, leads to peptide sequence modifications that can have substantial functional effects on protein stability, tissue-specific proteomes and dise...

Nature Biotechnology - Tech giants plunge into life sciences

Brandon, Robinson-Thiewes, Kaulage et al. report that targeted BRD4 recruitment enables transcription through H3K9me3/HP1-marked heterochromatin without erasing repressive marks, identifying condensat...

Nature Reviews Genetics, Published online: 13 July 2026; doi:10.1038/s41576-026-00988-6The protein complex cohesin shapes 3D genome organization through both cohesion and loop extrusion. The authors review the roles of these two mechanistic functions in the cellular response to DNA double-strand breaks, wherein cohesin acts to signal the presence of DNA damage, establish a repair environment, and catalyse the DNA repair process.

Human DNA replicates according to a precise schedule: certain regions are replicated early, while others replicate later in the cell cycle. The DNA sequence and the epigenome are both indicative for r...

The authors present INCOMMON, an open-source Bayesian inference tool that determines the multiplicity and copy number of driver mutations from tumor sequencing datasets.

This study introduces RF-PHATE, a supervised visualization method that preserves data structure while revealing biological patterns, enabling insights into disease progression in multiple sclerosis, C...

Nature Reviews Gastroenterology & Hepatology, Published online: 13 July 2026; doi:10.1038/s41575-026-01230-8Features of immune microenvironment associated with colorectal polyp development

Nature Reviews Genetics, Published online: 13 July 2026; doi:10.1038/s41576-026-00988-6The protein complex cohesin shapes 3D genome organization through both cohesion and loop extrusion. The authors review the roles of these two mechanistic functions in the cellular response to DNA double-strand breaks, wherein cohesin acts to signal the presence of DNA damage, establish a repair environment, and catalyse the DNA repair process.

In this Review, Grimm et al. describe the range of non-invasive diagnostic imaging approaches to monitor the various hallmarks of cancer and how their implementation is shaping clinical practice.

Recording from my workshop last week on smarter literature review with AI

Biology has clever ways to mask the effects of potentially harmful gene mutations. Scientists are investigating how this ‘buffering’ works — and how to exploit it.

Nature Reviews Genetics, Published online: 21 May 2026; doi:10.1038/s41576-026-00977-9In this Journal Club, Chatterjee and Rodger highlight two studies by Guo et al. and Shen et al. that demonstrated how genome-wide DNA methylation profiling enables sensitive detection and classification of tumour-derived cell-free DNA, advancing epigenetic approaches in liquid biopsy for cancer diagnostics.

Abstract. Aneuploidy is a hallmark of human tumors. While patient-level copy number alteration (CNA) differences have been investigated extensively in large cohorts, their intratumoral heterogeneity r...