iiinova — where your digital self keeps evolving

Genes & Diseases Journal @genesndiseases.bsky.social · 2h

A new molecular axis may explain how #ColorectalCancer spreads to the liver. This study reveals a Lyn–TRIB3–SOX9 axis in which #SuperEnhancers and phase separation activate MET transcription, promoting metastatic spread. #OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

000

Reposted by Genes & Diseases Journal

ESMO - European Society for Medical Oncology @myesmo.bsky.social · 6h

🌏 Global collaboration drives progress in GU oncology. Join the conversation at #ESMOGUAsia27 and share your latest research with experts from across Asia and the world. 📅 Abstract deadline: 13 October 👉 ow.ly/foEF50ZTNV2 #ESMOMeetings #GUOncology

022

Reposted by Genes & Diseases Journal

European Society for Radiotherapy and Oncology (ESTRO) @estroradiotherapy.bsky.social · 5h

🌟 Ahead of the 30 Oct submission deadline, guest editor Georgina Fröhlich shares why #phiRO, #ctRO & #tipsRO joined forces for the Highlights of #Brachytherapy 2026 special issue. 👉 Full interview: bit.ly/3TWAi4u 📅 Deadline: 30 Oct #radonc #openaccess #radiotherapy

021

Reposted by Genes & Diseases Journal

ESMO - European Society for Medical Oncology @myesmo.bsky.social · 5h

🤖 #ESMOAI26 : The wait is over! Abstract authors and titles are now online! What’s next for AI & Digital Oncology? Explore the science, technology, and real-world questions shaping the field at our upcoming event. ⏰ Register by 28 October and save! 🔗 ow.ly/7nQv50ZTNQX #esmomeetings

032

Genes & Diseases Journal @genesndiseases.bsky.social · 04/10/2026

Could a #RespiratorySyncytialVirus viral protein reshape infant immunity and disease severity? This study shows extracellular NS1 promotes TH2 differentiation, linking higher NS1 levels to immune changes and disease severity. #OpenAccess #GenesAndDiseases: doi.org/10.1016/j.ge...

000

Genes & Diseases Journal @genesndiseases.bsky.social · 04/10/2026

A new link between #inflammation and #LungFibrosis. Macrophage-derived ECM1 amplifies fibrosis via #TGFβ/HIF signalling, driving matrix remodelling and linking higher ECM1 to poorer survival. @unisouthampton.bsky.social #OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

000

Genes & Diseases Journal @genesndiseases.bsky.social · 03/10/2026

Why do #glioblastomas keep rebuilding themselves after treatment? This review reframes glioma stemness as a dynamic state shaped by #TumourPlasticity and brain niches, offering new paths to tackle resistance and recurrence. #OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

010

Genes & Diseases Journal @genesndiseases.bsky.social · 03/10/2026

Persistent #StaphylococcusAureus infection can evade immune clearance & drive chronic #BoneInfection. This study reveals α-hemolysin suppresses NF-κB signaling while evading degradation, enabling immune escape. #OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

131

Genes & Diseases Journal @genesndiseases.bsky.social · 03/10/2026

Could tiny RNA fragments reshape #NeurologicalDisease research? This review highlights how #tsRNAs regulate inflammation, oxidative stress and the blood–brain barrier, with potential as biomarkers & therapeutic targets. #CNS #OpenAccess #GenesAndDiseases: doi.org/10.1016/j.ge...

000

Genes & Diseases Journal @genesndiseases.bsky.social · 02/10/2026

Reliable #AlternativeSplicing detection is key for clinical biomarkers. This review highlights #RNAsequencing benchmarking, standardization and analytical optimization for reproducible results. #Bioinformatics #OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

000

Genes & Diseases Journal @genesndiseases.bsky.social · 02/10/2026

Low potassium in #hypertension may signal heightened organ risk. This review links #hypokalemia and low-normal #potassium to cardiovascular and renal injury, emphasizing systematic detection and cause-directed therapy. #OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

000

Reposted by Genes & Diseases Journal

ESMO - European Society for Medical Oncology @myesmo.bsky.social · 01/10/2026

📣 Abstract submission for #ELCC27 is now open. Share your research with a focused, multidisciplinary thoracic oncology community. Gain valuable feedback, increase the visibility of your work and start new collaborations. 🔗 Submit now - ow.ly/Jrtf50ZTpbk

143

Reposted by Genes & Diseases Journal

American Association for Cancer Research (AACR) @theaacr.bsky.social · 01/10/2026

Abstract submission is now open for the AACR Annual Meeting 2027 (April 2-7). Submit your abstract by November 10 and join us in Orlando to share the latest advances in cancer science and medicine. Learn more: buff.ly/WuSSXNE #AACR27

022

Reposted by Genes & Diseases Journal

European Society for Radiotherapy and Oncology (ESTRO) @estroradiotherapy.bsky.social · 01/10/2026

📢Coming up 6 October! Join the AGORA GEC-ESTRO Webinar “Inside Brachytherapy” for practical insights into the brachytherapy workflow, plus an interactive case vote and Q&A. 📅 6 Oct | 17:00–18:00 CEST | 💻 Online 👉 Register: bit.ly/4hmvhvb #AGORA #GECESTRO

011

Genes & Diseases Journal @genesndiseases.bsky.social · 02/10/2026

Nerve invasion changes far more than tumour spread. Pancreatic and #BiliaryCancers exploit nerve signalling to promote growth, #metastasis, and immune evasion, revealing new targets for #PrecisionTherapy. @tsinghua_uni #OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

000

Genes & Diseases Journal @genesndiseases.bsky.social · 01/10/2026

What happens to fat tissue under #hypertension? This study reveals #adipocyte dysfunction and macrophage inflammation driven by PPARγ/CBR3 activity, linking lipid accumulation to #CardiometabolicDisease. #WhiteAdiposeTissue #OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

000

Genes & Diseases Journal @genesndiseases.bsky.social · 01/10/2026

A newly uncovered brake on #HBV replication. HOXD1 limits HBV transcription by suppressing #UFMylation, revealing a host defence pathway that regulates NF-κB signalling and may offer a new therapeutic target for chronic hepatitis B. #GenesAndDiseases: doi.org/10.1016/j.ge...

000

Genes & Diseases Journal @genesndiseases.bsky.social · 01/10/2026

#HCC’s lipid addiction fuels tumor progression, but its regulatory drivers remain unclear. This study reveals the E2F1/LRRC1/FASN axis as a key regulator of lipid reprogramming, tumor growth and metastasis. #LipidAccumulation #OpenAccess #GenesAndDiseases: doi.org/10.1016/j.ge...

000

Genes & Diseases Journal @genesndiseases.bsky.social · 30/09/2026

UNC93B1 influences #autoimmunity beyond TLR trafficking. A gain-of-function variant linked to early-onset #lupus enhances dendritic-cell activation and #AntigenPresentation, promoting T-cell differentiation and immune dysregulation. #GenesAndDiseases: doi.org/10.1016/j.ge...

000

Genes & Diseases Journal @genesndiseases.bsky.social · 30/09/2026

How does epigenetic dysregulation drive kidney disease? #DNMT1 regulates renal inflammation, cell proliferation, apoptosis, #fibrosis and metabolic stress, making it a potential target for #KidneyDisease therapy. #OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

011

Reposted by Genes & Diseases Journal

International Association for the Study of Pain (IASP) @iasp.bsky.social · 29/09/2026

Sawasdee ka. I'm Ellie, the 2026 World Congress on Pain Ambassador. One month to go: complete your registration, review the pre-congress program and add any remaining events to your plans. See you in Bangkok on 26 October: bit.ly/3V9ZYLi

012

Reposted by Genes & Diseases Journal

EACR - European Association for Cancer Research @helloeacr.bsky.social · 29/09/2026

Hosted by the EACR and QIAGEN, the ‘Transcriptome and repertoire profiling of infiltrating γδ T cells to decode tumor escape at single cell resolution’ webinar is now open for registrations. Wednesday 07 October, 14:00-15:00 CEST Learn more and register here: us02web.zoom.us/webinar/regi...

011

Reposted by Genes & Diseases Journal

American Association for Cancer Research (AACR) @theaacr.bsky.social · 29/09/2026

Register by October 27 to get the lowest rates for the AACR Conference on Advances in the Pathogenesis and Immune Therapies of Liver Cancer (December 6-8; Austin, Texas), chaired by Richard S. Finn, Josep M. Llovet, and Jessica Zucman-Rossi. buff.ly/QuyRLts #AACRliver26 @zucmanrossi.bsky.social

022

Genes & Diseases Journal @genesndiseases.bsky.social · 30/09/2026

Small chemical changes can have major biological consequences. This review links #LysineSuccinylation to #cancer, #neurodegeneration, and metabolic disease, highlighting therapies that target the enzymes controlling this modification. #GenesAndDiseases: doi.org/10.1016/j.ge...

000

Genes & Diseases Journal @genesndiseases.bsky.social · 29/09/2026

Can targeted nanoparticles boost gemcitabine? Butein-loaded #PLGAnanoparticles combined with gemcitabine reduce resistance, suppress #PancreaticTumors and extend survival in PDAC models. @mayoclinicgimfl.bsky.social #OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

000

Genes & Diseases Journal @genesndiseases.bsky.social · 29/09/2026

Why do so many #cancers eventually stop responding to treatment? This review shows how protein modifications rewire tumour defences and highlights emerging strategies, from #PROTACs to #AI-guided approaches, to overcome resistance. #GenesAndDiseases: doi.org/10.1016/j.ge...

001

Genes & Diseases Journal @genesndiseases.bsky.social · 29/09/2026

What controls the balance between #cartilage and #BoneFormation? ST3GAL1-associated α-2,3 sialylation regulates chondrocyte and #osteoblast differentiation, with its loss impairing growth plate maturation & reducing bone mass. #OpenAccess #GenesAndDiseases: doi.org/10.1016/j.ge...

000

Genes & Diseases Journal @genesndiseases.bsky.social · 28/09/2026

#CRISPRCas is reshaping the future of #PrecisionMedicine. This review explores its mechanisms, delivery and medical applications, while highlighting challenges in efficiency, transcriptional control and biosafety. #OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

000

Genes & Diseases Journal @genesndiseases.bsky.social · 28/09/2026

Could #tumor metabolism drive T-cell exhaustion? CD147 enhances tryptophan uptake and kynurenine production in #NSCLC, promoting CD8+ T-cell exhaustion, while CD147-targeted CAR-T plus anti-PD-1 shows therapeutic potential. #OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

020

Genes & Diseases Journal @genesndiseases.bsky.social · 28/09/2026

Targeting RRM2 could tackle both #HCC and #HBV. This study identifies HP28 and HP39 as RRM2 inhibitors that deplete dNTPs, suppress #tumor growth and HBV replication, and retain activity against sorafenib-resistant HCC. #OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

000

Genes & Diseases Journal @genesndiseases.bsky.social · 28/09/2026

#Phosphorylation may hold a key to slowing #osteoarthritis. This review shows how MAPK, PI3K/AKT and NF-κB phosphorylation regulate chondrocyte metabolism, apoptosis and inflammation, revealing new therapeutic opportunities. #OpenAccess #GenesAndDiseases: doi.org/10.1016/j.ge...

000

Genes & Diseases Journal @genesndiseases.bsky.social · 27/09/2026

Could a frequently mutated gene reveal new vulnerabilities in #HepatocellularCarcinoma (HCC)? This study identifies PTPRG as a #TumorSuppressor whose loss activates FAK/PI3K/AKT signaling, promoting HCC progression. #OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

000

Reposted by Genes & Diseases Journal

American Association for Cancer Research (AACR) @theaacr.bsky.social · 25/09/2026

Register by December 15 to get the lowest rates for the AACR Special Conference on Redefining Lung Cancer (January 14-17; San Diego), held in association with the AACR Lung Cancer Task Force and chaired by Charles Swanton. Learn more: buff.ly/hGLGu07 #AACRlung27 @charlesswanton.bsky.social

022

Reposted by Genes & Diseases Journal

American Association for Cancer Research (AACR) @theaacr.bsky.social · 25/09/2026

The AACR Conference on New Frontiers in the Biology of and Therapeutic Development for Pancreatic Cancer opens this evening in San Diego with a keynote lecture by Andrew J. Aguirre. #AACRpan26

083

Reposted by Genes & Diseases Journal

European Society for Radiotherapy and Oncology (ESTRO) @estroradiotherapy.bsky.social · 26/09/2026

🫁 Join the upcoming Lung Webinar for expert insights into combining RT and immunotherapy, from timing and dose to advanced RT techniques. 📅 13 Oct | 16:30–18:00 CEST | Online 👉 Register: bit.ly/4hKH8D8 #ESTRO #NSCLC #LungCancer #RadiationOncology

021

Genes & Diseases Journal @genesndiseases.bsky.social · 27/09/2026

#BrainMetastases are shaped by complex #TumorMicroenvironment interactions. This study identifies the MIF–CD74 axis as a key tumor–myeloid hub and links pDC signatures to shorter survival, highlighting a potential target. #OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

000

Genes & Diseases Journal @genesndiseases.bsky.social · 26/09/2026

What drives chondrocyte hypertrophy in #osteoarthritis? This study identifies #POSTN as a regulator of #RUNX2-driven hypertrophy, with its suppression reducing cartilage damage, synovial inflammation and OA progression. #OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

000

Genes & Diseases Journal @genesndiseases.bsky.social · 26/09/2026

Targeting #IRF4 could open a new path for #MultipleMyeloma therapy. G1126 suppresses myeloma growth, reduces lenalidomide-resistant cells and enhances #chemotherapy response while sparing normal stem cells. @ECNUER #GenesAndDiseases: doi.org/10.1016/j.ge...

010

Genes & Diseases Journal @genesndiseases.bsky.social · 26/09/2026

Could #platelets provide a window into #ParkinsonsDisease? This study identifies shared chromatin pathways and highlights platelet-derived CRLF3 and LRRC37A2 as promising diagnostic #biomarkers for PD. @pku1898.bsky.social #OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

000

Genes & Diseases Journal @genesndiseases.bsky.social · 25/09/2026

A new #antiviral mechanism may help tackle #HepatitisBvirus persistence. FAM151A suppresses HBV replication by inhibiting cccDNA transcription without reducing its abundance, revealing a host defense mechanism against HBV infection. #GenesAndDiseases: doi.org/10.1016/j.ge...

111

Reposted by Genes & Diseases Journal

European Society for Radiotherapy and Oncology (ESTRO) @estroradiotherapy.bsky.social · 24/09/2026

📢 ASTRO/ESTRO Joint Session at #ASTRO2026 Explore the present and future impact of AI on clinical care delivery in radiation oncology. 🗣️ Barbara Jereczek-Fossa & Neha Vapiwala 📍 Room 160, Boston 👉 bit.ly/46C2c8N #ESTRO #AI #RadiationOncology

011

Reposted by Genes & Diseases Journal

European Society for Radiotherapy and Oncology (ESTRO) @estroradiotherapy.bsky.social · 24/09/2026

🧠 EANO-ESTRO Joint Session at #EANO2026 Join “Toward Precision and Cognitive-Sparing Radiotherapy in Gliomas” and hear from the ESTRO speakers 📅 27 Sep | 🕘 09:00–10:30 CEST 📍 Sinopoli Hall, Rome 👉 bit.ly/4hJiFy7 #ESTRO #EANO #Radonc

044

Reposted by Genes & Diseases Journal

European Organisation for Research and Treatment of Cancer @eortc.org · 25/09/2026

📢 Get ready for #ENASymp26 Late-Breaking Abstract submissions! Submit your latest data 12–19 October 2026. 📍 Barcelona 18–20 November 👉 Register: event.eortc.org/ena2026/registration American Association for Cancer Research (AACR) The National Cancer Institute #CancerResearch #Oncology

011

Genes & Diseases Journal @genesndiseases.bsky.social · 25/09/2026

A new strategy could improve #IntrahepaticCholangiocarcinoma (ICC) therapy. This study shows PD-161570 suppresses YY1-driven #AURKA transcription and synergizes with MLN8237, inhibiting ICC progression in vitro and in vivo. #OpenAccess #GenesAndDiseases: doi.org/10.1016/j.ge...

000

Genes & Diseases Journal @genesndiseases.bsky.social · 25/09/2026

What keeps #βCatenin active in cancer? This study identifies #Doublecortin as a novel regulator that stabilizes β-Catenin, enhances its transcriptional activity and promotes #HCC progression. @emorydeptofmed.bsky.social #OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

010

Genes & Diseases Journal @genesndiseases.bsky.social · 24/09/2026

Mitochondrial redox balance could reveal new cancer clues. This pan-cancer study links SLC25A39 to tumor progression, immune checkpoints and #immunotherapy response, highlighting its #biomarker potential. #GastricCancer #OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

011

Genes & Diseases Journal @genesndiseases.bsky.social · 24/09/2026

Can #AI move beyond prediction to explain disease? This review outlines how trustworthy AI can link #MultiOmics, imaging, pathology and real-world data to biological mechanisms, robust validation and #PrecisionMedicine. #OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

000

Genes & Diseases Journal @genesndiseases.bsky.social · 24/09/2026

#InflammatoryBowelDisease (IBD) involves more than persistent inflammation. This review highlights how #ferroptosis, iron overload and microbiota–immune interactions drive barrier damage and reveal new therapeutic targets. #OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

000

Genes & Diseases Journal @genesndiseases.bsky.social · 23/09/2026

Which genes drive early #PancreaticCancer metastasis? Integrating transcriptomic, single-cell and #MachineLearning data identified ITGA3 as a key pro-metastatic gene and potential therapeutic target in PDAC. #OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

000

Genes & Diseases Journal @genesndiseases.bsky.social · 23/09/2026

Why does #ColorectalCancer keep resisting #5Fluorouracil chemotherapy? This study shows that arachidonic acid–driven lipophagy sustains resistant cells, suggesting a strategy to restore chemotherapy sensitivity. #DrugResistance #OpenAccess #GenesAndDiseases: doi.org/10.1016/j.ge...

010