Congenital dyserythropoietic anaemia type I is caused by mutations in CDAN1 or CDIN1, but the molecular basis of disease is unclear. Here, the authors show that Codanin-1 and CDIN1 form an RNA nucleas...

Hoslett et al. show that trapped PARP1 is cleared from the nucleus by nucleophagy involving the autophagy receptor TEX264 and p97. Inactivation of nucleophagy resensitizes acquired resistance of BRCA1...

Last week, Mr Keaton Jones attended a Pancreatic Cancer UK parliamentary reception at the House of Commons which brought together 50 MPs, government representatives, researchers, patients, and suppor...

A new study led by Professor Geoff Higgins at the Department of Oncology, in collaboration with Artios Pharma, has uncovered a genetic vulnerability that could help identify patients most likely to benefit from a promising radiotherapy combination treatment. Published today in Science Advances, the research identifies loss of SHLD2 as a predictive biomarker for treatment with DNA polymerase theta (Polθ) inhibitors, an emerging class of DNA repair-targeted drugs.

npj Breast Cancer - HIF-1–regulated TPM3 links hypoxia to motility and invasion beyond the hypoxic fraction in triple-negative breast cancer

Researchers have developed a promising new compound designed to reduce tumour hypoxia, a major cause of radiotherapy resistance.

Researchers from the Department of Oncology are part of a €50 million European project looking at how innovative medical and digital technologies can improve the early detection of heart-related problems in cancer patients and survivors.

New data published today in the European Society for Medical Oncology (ESMO) Real World Data and Digital Oncology show that more than half of people receiving systemic anticancer treatment had a history of obesity, compared with only around one in four who were classified as obese at the time their treatment began.

A new EPSRC-funded research project led by Dr Kristoffer Petersson aims to advance the clinical implementation of FLASH radiotherapy, an emerging technique that delivers radiation in a fraction of a second and may significantly reduce treatment side effects.

An event focused on advancing scientific collaboration and improving outcomes for liver cancer.

A new EPSRC-funded research project led by Dr Kristoffer Petersson aims to advance the clinical implementation of FLASH radiotherapy, an emerging technique that delivers radiation in a fraction of a s...

AbstractObjectives. FLASH radiotherapy is an innovative technique that delivers radiation at ultra-high dose rates (UHDR), offering tumour control comparab

In a study published today in Nature Medicine, researchers from the University of Oxford and the Muhimbili University of Health and Allied Sciences (MUHAS) in Dar es salaam, Tanzania have shown that a...

Research published in Science Advances has uncovered new insights into why the most aggressive oesophageal cancers are so difficult to treat and how the body’s own defence systems are helping them to

Research published today in Science Advances has uncovered new insights into why the most aggressive oesophageal cancers are so difficult to treat and how the body’s own defence systems are helping th...

An event focused on advancing scientific collaboration and improving treatments for oesophagogastric cancer.

A new clinical study has launched to investigate whether insulin levels influence how women with the most common type of breast cancer respond to treatment.

Researchers from the Jiang Group in the Department of Oncology have published Phase Ia clinical trial results for OVM-200, a novel cancer vaccine targeting survivin. The first-in-human trial,…

Researchers at the University of Oxford have developed TrustedMDT, a multi-agent artificial intelligence (AI) system designed to support medical specialists during cancer treatment planning meetings.

The Department of Oncology is proud to share that Kendra Perez-Smith, Translational Support Unit (TSU) Manager, has received an Outstanding Contribution to Sustainability Award in recognition of her i...

Researchers at the Department of Oncology have developed TrustedMDT, a multi-agent artificial intelligence (AI) system designed to support medical specialists during cancer treatment planning meetings...

Over the past year, Professor Blagden has been filming for Cancer Detectives: Finding the Cures, a new three-part documentary series from Channel 4 which follows three scientists on the front lines of...

Three trailblazing scientists take on cancer, changing peoples’ lives, right now

People at high risk of lung cancer will soon be able to receive the first-ever experimental vaccine, 'LungVax', designed to prevent the disease, in a world-first clinical trial. The LungVax vaccine ca...