Nature Reviews Gastroenterology & Hepatology, Published online: 29 September 2026; doi:10.1038/s41575-026-01261-1Asia bears a disproportionate burden of digestive and liver diseases but remains under-represented in global research leadership. This Comment examines structural, cultural and institutional barriers to developing clinician-scientists in Asia, highlights successful regional models and proposes strategies to strengthen training, mentorship and research capacity.

Nature Reviews Gastroenterology & Hepatology, Published online: 29 September 2026; doi:10.1038/s41575-026-01261-1Asia bears a disproportionate burden of digestive and liver diseases but remains under-represented in global research leadership. This Comment examines structural, cultural and institutional barriers to developing clinician-scientists in Asia, highlights successful regional models and proposes strategies to strengthen training, mentorship and research capacity.

Nature Reviews Gastroenterology & Hepatology, Published online: 23 September 2026; doi:10.1038/s41575-026-01263-zESPEN 2026

Nature Reviews Gastroenterology & Hepatology, Published online: 18 September 2026; doi:10.1038/s41575-026-01260-2The environment is a critical factor in the development of inflammatory bowel disease (IBD). In this Perspective, the authors summarize the latest evidence on the exposome and IBD risk, encompassing physical, chemical, biological and psychosocial components. They discuss innovation and challenges alongside a framework for IBD prevention by modulating the exposome.

Nature Reviews Gastroenterology & Hepatology, Published online: 23 September 2026; doi:10.1038/s41575-026-01263-zESPEN 2026

Nature Reviews Gastroenterology & Hepatology, Published online: 23 September 2026; doi:10.1038/s41575-026-01263-zESPEN 2026

Nature Reviews Gastroenterology & Hepatology, Published online: 14 September 2026; doi:10.1038/s41575-026-01257-xIn this Review, Yuen and colleagues describe the epidemiology, diagnosis, pathophysiology and clinical management of occult hepatitis B virus infection, and propose some future directions for research.

Nature Reviews Gastroenterology & Hepatology, Published online: 14 September 2026; doi:10.1038/s41575-026-01258-wMany compounds not classified as antibiotics can exert antimicrobial activity, with drug–microbiome–host interactions having profound effects on the human microbiome and human health. This Review explores how non-antibiotic compounds exert these antimicrobial effects, highlighting which compounds can influence the microbiome, the underlying mechanisms, and implications for translation and clinical practice.

Nature Reviews Gastroenterology & Hepatology, Published online: 18 September 2026; doi:10.1038/s41575-026-01260-2The environment is a critical factor in the development of inflammatory bowel disease (IBD). In this Perspective, the authors summarize the latest evidence on the exposome and IBD risk, encompassing physical, chemical, biological and psychosocial components. They discuss innovation and challenges alongside a framework for IBD prevention by modulating the exposome.

Nature Reviews Gastroenterology & Hepatology, Published online: 18 September 2026; doi:10.1038/s41575-026-01260-2The environment is a critical factor in the development of inflammatory bowel disease (IBD). In this Perspective, the authors summarize the latest evidence on the exposome and IBD risk, encompassing physical, chemical, biological and psychosocial components. They discuss innovation and challenges alongside a framework for IBD prevention by modulating the exposome.

Nature Reviews Gastroenterology & Hepatology, Published online: 09 September 2026; doi:10.1038/s41575-026-01259-9A notable subset of people with inflammatory bowel disease remain unwell despite objective remission. Their ‘residual burden’ is too often misinterpreted as inflammation and can be treated as such. These symptoms, not attributable to active inflammation, deserve to be recognized as a treatment target in their own right and managed alongside disease control.

Nature Reviews Gastroenterology & Hepatology, Published online: 09 September 2026; doi:10.1038/s41575-026-01255-zMetabolic dysfunction-associated steatotic liver disease is a systemic cardiometabolic disease requiring integrated heart–liver co-management. This Expert Recommendation provides practical guidance on awareness, screening, treatment, clinical trial design and guideline implementation within a multisystem metabolic care framework.

Nature Reviews Gastroenterology & Hepatology, Published online: 14 September 2026; doi:10.1038/s41575-026-01257-xIn this Review, Yuen and colleagues describe the epidemiology, diagnosis, pathophysiology and clinical management of occult hepatitis B virus infection, and propose some future directions for research.

Nature Reviews Gastroenterology & Hepatology, Published online: 14 September 2026; doi:10.1038/s41575-026-01258-wMany compounds not classified as antibiotics can exert antimicrobial activity, with drug–microbiome–host interactions having profound effects on the human microbiome and human health. This Review explores how non-antibiotic compounds exert these antimicrobial effects, highlighting which compounds can influence the microbiome, the underlying mechanisms, and implications for translation and clinical practice.

Nature Reviews Gastroenterology & Hepatology, Published online: 14 September 2026; doi:10.1038/s41575-026-01258-wMany compounds not classified as antibiotics can exert antimicrobial activity, with drug–microbiome–host interactions having profound effects on the human microbiome and human health. This Review explores how non-antibiotic compounds exert these antimicrobial effects, highlighting which compounds can influence the microbiome, the underlying mechanisms, and implications for translation and clinical practice.

Nature Reviews Gastroenterology & Hepatology, Published online: 14 September 2026; doi:10.1038/s41575-026-01257-xIn this Review, Yuen and colleagues describe the epidemiology, diagnosis, pathophysiology and clinical management of occult hepatitis B virus infection, and propose some future directions for research.

Nature Reviews Gastroenterology & Hepatology, Published online: 09 September 2026; doi:10.1038/s41575-026-01259-9A notable subset of people with inflammatory bowel disease remain unwell despite objective remission. Their ‘residual burden’ is too often misinterpreted as inflammation and can be treated as such. These symptoms, not attributable to active inflammation, deserve to be recognized as a treatment target in their own right and managed alongside disease control.

Nature Reviews Gastroenterology & Hepatology, Published online: 09 September 2026; doi:10.1038/s41575-026-01255-zMetabolic dysfunction-associated steatotic liver disease is a systemic cardiometabolic disease requiring integrated heart–liver co-management. This Expert Recommendation provides practical guidance on awareness, screening, treatment, clinical trial design and guideline implementation within a multisystem metabolic care framework.

Nature Reviews Gastroenterology & Hepatology, Published online: 03 September 2026; doi:10.1038/s41575-026-01242-4Major advances have deepened our understanding of intestinal stem (ISC) biology, yet the clinical translation remains limited, despite the promise of harnessing ISCs for both mucosal repair and regenerating functioning intestinal tissue. This Roadmap outlines progress, challenges and opportunities in the translation of ISC research to clinical therapy.

Nature Reviews Gastroenterology & Hepatology, Published online: 09 September 2026; doi:10.1038/s41575-026-01259-9A notable subset of people with inflammatory bowel disease remain unwell despite objective remission. Their ‘residual burden’ is too often misinterpreted as inflammation and can be treated as such. These symptoms, not attributable to active inflammation, deserve to be recognized as a treatment target in their own right and managed alongside disease control.

Nature Reviews Gastroenterology & Hepatology, Published online: 09 September 2026; doi:10.1038/s41575-026-01255-zMetabolic dysfunction-associated steatotic liver disease is a systemic cardiometabolic disease requiring integrated heart–liver co-management. This Expert Recommendation provides practical guidance on awareness, screening, treatment, clinical trial design and guideline implementation within a multisystem metabolic care framework.

Nature Reviews Gastroenterology & Hepatology, Published online: 02 September 2026; doi:10.1038/s41575-026-01250-4In this Review, the authors critically discuss the rationale, challenges and opportunities for radiotherapy–immunotherapy combinations in localized pancreatic cancer. Preclinical and clinical data are examined, drawing on evidence from pancreatic cancer and other cancer types and reframing radiation therapy as a potential immunological platform.

Nature Reviews Gastroenterology & Hepatology, Published online: 01 September 2026; doi:10.1038/s41575-026-01243-3Long non-coding RNAs (lncRNAs) are emerging as key regulators in cancer progression, including colorectal cancer (CRC). This Review provides a mechanistic overview of the role of lncRNAs in the CRC microenvironment and discusses their potential in precision oncology.

Nature Reviews Gastroenterology & Hepatology, Published online: 03 September 2026; doi:10.1038/s41575-026-01242-4Major advances have deepened our understanding of intestinal stem (ISC) biology, yet the clinical translation remains limited, despite the promise of harnessing ISCs for both mucosal repair and regenerating functioning intestinal tissue. This Roadmap outlines progress, challenges and opportunities in the translation of ISC research to clinical therapy.

Nature Reviews Gastroenterology & Hepatology, Published online: 03 September 2026; doi:10.1038/s41575-026-01242-4Major advances have deepened our understanding of intestinal stem (ISC) biology, yet the clinical translation remains limited, despite the promise of harnessing ISCs for both mucosal repair and regenerating functioning intestinal tissue. This Roadmap outlines progress, challenges and opportunities in the translation of ISC research to clinical therapy.

Nature Reviews Gastroenterology & Hepatology, Published online: 02 September 2026; doi:10.1038/s41575-026-01250-4In this Review, the authors critically discuss the rationale, challenges and opportunities for radiotherapy–immunotherapy combinations in localized pancreatic cancer. Preclinical and clinical data are examined, drawing on evidence from pancreatic cancer and other cancer types and reframing radiation therapy as a potential immunological platform.

Nature Reviews Gastroenterology & Hepatology, Published online: 01 September 2026; doi:10.1038/s41575-026-01243-3Long non-coding RNAs (lncRNAs) are emerging as key regulators in cancer progression, including colorectal cancer (CRC). This Review provides a mechanistic overview of the role of lncRNAs in the CRC microenvironment and discusses their potential in precision oncology.

Nature Reviews Gastroenterology & Hepatology, Published online: 02 September 2026; doi:10.1038/s41575-026-01250-4In this Review, the authors critically discuss the rationale, challenges and opportunities for radiotherapy–immunotherapy combinations in localized pancreatic cancer. Preclinical and clinical data are examined, drawing on evidence from pancreatic cancer and other cancer types and reframing radiation therapy as a potential immunological platform.

Nature Reviews Gastroenterology & Hepatology, Published online: 01 September 2026; doi:10.1038/s41575-026-01243-3Long non-coding RNAs (lncRNAs) are emerging as key regulators in cancer progression, including colorectal cancer (CRC). This Review provides a mechanistic overview of the role of lncRNAs in the CRC microenvironment and discusses their potential in precision oncology.

Nature Reviews Gastroenterology & Hepatology, Published online: 26 August 2026; doi:10.1038/s41575-026-01252-2Reply to ‘Closing the policy gap: including children in the global agenda for steatotic liver disease’

Nature Reviews Gastroenterology & Hepatology, Published online: 26 August 2026; doi:10.1038/s41575-026-01253-1Closing the policy gap: including children in the global agenda for steatotic liver disease

Nature Reviews Gastroenterology & Hepatology, Published online: 25 August 2026; doi:10.1038/s41575-026-01256-yThe global profile of Chinese hepatology has expanded rapidly over the past four decades, driven by major scientific investment, increased global mobility and landmark clinical and translational discoveries. As a new generation of Chinese investigators emerges around the globe, initiatives that foster international collaboration, mentorship and scientific exchange will be essential for advancing the future of global liver research.

Nature Reviews Gastroenterology & Hepatology, Published online: 24 August 2026; doi:10.1038/s41575-026-01246-0Noncommunicable diseases kill 43 million people worldwide yearly, but one of their key biological drivers, the disruption of the gut microbiome by modifiable environmental factors, is still underappreciated by health stakeholders. The translation of microbiome science into concrete actions, from food safety regulators to public health authorities and policymakers, is urgently needed.

Nature Reviews Gastroenterology & Hepatology, Published online: 26 August 2026; doi:10.1038/s41575-026-01252-2Reply to ‘Closing the policy gap: including children in the global agenda for steatotic liver disease’

Nature Reviews Gastroenterology & Hepatology, Published online: 26 August 2026; doi:10.1038/s41575-026-01253-1Closing the policy gap: including children in the global agenda for steatotic liver disease

Nature Reviews Gastroenterology & Hepatology, Published online: 20 August 2026; doi:10.1038/s41575-026-01254-0Phase I trial of faecal microbiome transplantation for food allergy

Nature Reviews Gastroenterology & Hepatology, Published online: 25 August 2026; doi:10.1038/s41575-026-01256-yThe global profile of Chinese hepatology has expanded rapidly over the past four decades, driven by major scientific investment, increased global mobility and landmark clinical and translational discoveries. As a new generation of Chinese investigators emerges around the globe, initiatives that foster international collaboration, mentorship and scientific exchange will be essential for advancing the future of global liver research.

Nature Reviews Gastroenterology & Hepatology, Published online: 26 August 2026; doi:10.1038/s41575-026-01253-1Closing the policy gap: including children in the global agenda for steatotic liver disease

Nature Reviews Gastroenterology & Hepatology, Published online: 26 August 2026; doi:10.1038/s41575-026-01252-2Reply to ‘Closing the policy gap: including children in the global agenda for steatotic liver disease’

Nature Reviews Gastroenterology & Hepatology, Published online: 19 August 2026; doi:10.1038/s41575-026-01244-2In this Review, Jain and Monga describe the mechanisms of hepatic sexual dimorphism in homeostasis and physiological conditions, as well as in the pathophysiology of diseases such as metabolic dysfunction-associated steatotic liver disease, autoimmune diseases, viral hepatitis and liver cancer.

Nature Reviews Gastroenterology & Hepatology, Published online: 25 August 2026; doi:10.1038/s41575-026-01256-yThe global profile of Chinese hepatology has expanded rapidly over the past four decades, driven by major scientific investment, increased global mobility and landmark clinical and translational discoveries. As a new generation of Chinese investigators emerges around the globe, initiatives that foster international collaboration, mentorship and scientific exchange will be essential for advancing the future of global liver research.

Nature Reviews Gastroenterology & Hepatology, Published online: 24 August 2026; doi:10.1038/s41575-026-01246-0Noncommunicable diseases kill 43 million people worldwide yearly, but one of their key biological drivers, the disruption of the gut microbiome by modifiable environmental factors, is still underappreciated by health stakeholders. The translation of microbiome science into concrete actions, from food safety regulators to public health authorities and policymakers, is urgently needed.

Nature Reviews Gastroenterology & Hepatology, Published online: 18 August 2026; doi:10.1038/s41575-026-01251-3Relieving IBD with duvakitug

Nature Reviews Gastroenterology & Hepatology, Published online: 18 August 2026; doi:10.1038/s41575-026-01247-zNoninvasive testing for fibrosis and cirrhosis in MASLD

Nature Reviews Gastroenterology & Hepatology, Published online: 18 August 2026; doi:10.1038/s41575-026-01240-6In this Review, Loomba and colleagues describe the global epidemiology, risk factors, natural history and clinical implications of metabolic and alcohol-associated liver disease (MetALD).

Nature Reviews Gastroenterology & Hepatology, Published online: 18 August 2026; doi:10.1038/s41575-026-01249-xA patient advocate asked what decades of fibrosis research meant for the people he represented. I had no answer. That question exposed a gap that the scientific community must now confront: between the knowledge we generate and the means to deliver it to patients.