I am happy to share that my PhD work on a pan-cancer single-cell analysis of intratumoral copy number diversity and evolution is now out as a pre-proof in Cancer Discovery. In this paper, we profiled 62,646 aneuploid cells from 94 tumors across 7 major human cancer types using single-cell DNA-seq.
aacrjournals.org
A pan-cancer single-cell analysis of intratumoral copy number diversity and evolution
Abstract. Aneuploidy is a hallmark of human tumors. While patient-level copy number alteration (CNA) differences have been investigated extensively in large cohorts, their intratumoral heterogeneity r...