iiinova — where your digital self keeps evolving

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Venkat Rao @venkyrao.bsky.social · 26/09/2026

Jumping on the bandwagon with a 3D view of Xenopus multiciliated cells: cilia (magenta) sprouting above the apical actin network (cyan) 🐸. Not live, but no #AISLOP

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Cells & Development @cellsdev.bsky.social · 25/09/2026

We're in love with our September issue cover! This stunning cover is from an article by the Rosin lab showing how CSF1R signaling impacts not only immune cells but also musculoskeletal development. Check out the article here: www.sciencedirect.com/science/arti...

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Cells & Development @cellsdev.bsky.social · 25/09/2026

We heard through the vines that #cilia are hot (or not?) right now so here is a cool article by the Saxena lab about how Notch signalling inhibit zebrafish olfactory multiciliated cells differentiation 🐟 AND we got a cool movie with it too! #FluorescenceFriday www.sciencedirect.com/science/arti...

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Anh Hoang Le, PhD 🏳️‍🌈🏴󠁧󠁢󠁳󠁣󠁴󠁿🇻🇳 @anhhle2702.bsky.social · 25/09/2026

Happy #FluorescenceFriday. The first time I imaged a 🐸 embryo, I didn't realise they had these ciliated cells on the outer surface. So you can imagine how surprised and curious I was! These cilia are similar to those found in the human airway. And yes, this is just a good old confocal + 🔥LUT!

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International Society of Developmental Biology @isdb.bsky.social · 25/09/2026

(Real) cilia are hot 👀 👀 ??? Look at them dance 😍 #FluorescenceFriday

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Cells & Development @cellsdev.bsky.social · 25/09/2026

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International Society of Developmental Biology @isdb.bsky.social · 25/09/2026

Upcoming #evodevo and mechanics conference in Paris #Evodevmec2026: www.developmental-biology.org/meetings-and... evodevmec2026.sciencesconf.org?lang=en

evodevmec2026.sciencesconf.org

Roadmap for EvoDevoMec - Sciencesconf.org

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European Research Council (ERC) @erc.europa.eu · 25/09/2026

📢 2027 ERC Consolidator Grant call for proposals is now open 📢 Have an excellent research idea and ready to build the team to pursue it? This funding could be for you! Deadline: 12 January 2027 👉 link.europa.eu/g4NrCc

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Cells & Development @cellsdev.bsky.social · 25/09/2026

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Marine Biological Laboratory @mblscience.bsky.social · 22/09/2026

APPLICATIONS OPEN‼️ Apply to the Grass Fellowship by December 1 and gain access to research support including laboratory space, animals, equipment and supplies for one summer at the MBL. Partnered with @grassfoundation.bsky.social 🔗 More info here: go.mbl.edu/grass2026

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James Briscoe @jamesbriscoe.bsky.social · 22/09/2026

Our latest paper on building models of cell fate decisions -with David Rand, Marine Fontaine & @joadelas.bsky.social- combines developmental biology, dynamical systems theory and bioinformatics. I wrote a short piece to summarise it & explain ideas behind the approach briscoelab.org/blog-quantif...

briscoelab.org

Quantifying Waddington's Landscape | Briscoe Lab

I have written before about how two conceptual frameworks have shaped our thinking about cell fate, Waddington's epigenetic landscape and Davidson's gene...

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Development @dev-journal.bsky.social · 21/09/2026

At Development, we #LovePostdocs. For #NPAW2026, we highlight our 2026 cohort of Pathway to Independence fellows. Read about their unique journeys as they work to secure independent positions, their excitement about the latest advances in their fields & the advice they have received along the way.

journals.biologists.com

Dev | PI fellows 2026 | Development | The Company of Biologists

Dev | PI fellows 2026 | Development | The Company of Biologists .card-list-container { margin-top: 2em; } .card-list-container h2 { margin-bottom: 1em; } .ca...

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FocalPlane @focalplane.bsky.social · 11/09/2026

Our beautiful ‘Featured image’ this #FluorescenceFriday was acquired by @enicolay.bsky.social. The image shows a #zebrafish larvae with macrophages and neurons depicted in different colours. Learn more about Elena’s research: focalplane.biologists.com/2026/09/11/f...

focalplane.biologists.com

Featured image with Elena Nicolay - FocalPlane

Featured image with Elena Nicolay - News

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Waggoner Lab @labwaggoner.bsky.social · 11/09/2026

Targeting tumor-associated macrophages using mRNA lipid nanoparticles for cytotoxic T lymphocyte–mediated cancer immunotherapy www.science.org/doi/10.1126/...

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Floris BOSVELD @florisbosveld.bsky.social · 11/09/2026

Join us for the symposium Morphogenesis: Where Form Takes Shape Oct. 27-28 Institute Curie Paris Free attendance, but registration is required. Short talks and posters will be selected from submitted abstracts. Abstract submission deadline: Oct. 10, 2026.

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Philippe Batut @philippebatut.bsky.social · 10/09/2026

🧬🔬 Why are enhancers transcribed and how does that impact gene regulation? I’m really excited to share our new paper in @science.org showing that noncoding RNAs control the timing of gene activation in embryos. With Mike Levine #ScienceResearch @columbiamed.bsky.social A few highlights below... 🧵👇

science.org

Noncoding transcription controls the developmental dynamics of long-range gene regulation

The genomic regions regulating gene expression are often themselves transcribed into a variety of noncoding RNAs (ncRNAs). However, the regulatory roles of this noncoding transcription remain largely ...

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Melanie D. White @melaniedwhite.bsky.social · 11/09/2026

Happy #FluorescenceFriday! ✨ It's the glue that holds us together, but it looks like a pair of angel wings to me. 👼 This beautiful meshwork of extracellular matrix surrounds the developing tissues of a quail embryo, helping guide cells as they build the body. 📷 @wangjianxiong.bsky.social 🔬

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Goutham @kodakandlag.bsky.social · 11/09/2026

Like stars in the night sky 😍 #FluorescenceFriday but make it live cell calcium imaging

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Journal of Cell Biology @jcb.org · 10/09/2026

Lipid-mediated activation of BLT2 promotes membrane repair to prevent cell death. New study from Yuan Chi, Kazuko Saeki, Takehiko Yokomizo and colleagues (Juntendo University): rupress.org/jcb/article/... #Biochemistry #Membrane #lipid

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Cells & Development @cellsdev.bsky.social · 11/09/2026

Our latest published issue cover is here. From zebrafish 🐟 heart regeneration to deep learning based segmentation to insulin resistant. Check out our latest issue here: 👇👇👇 www.sciencedirect.com/journal/cell... #devbio

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Sonya Neal @neal-lab.bsky.social · 11/09/2026

So exciting to see our work featured by @jcb.org ! 🎉 This study brings together proteomics, zebrafish & rhomboid biology. New in the final paper: Dr. Kvido Strisovsky Rhbdl2 inhibitor beautifully phenocopied the R2 KO. So proud of Saroj and grateful to co-authors and collaborators! 💕

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Anna Bodzeta @annabodzeta.bsky.social · 11/09/2026

While waiting for the manuscript to be uploaded on bioRxiv, here some sneak peek #FluorescenceFriday

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Stacey Ogden 🦔 @labogden.bsky.social · 11/09/2026

Happy #FluorescenceFriday! Question: How long can a #cytoneme get? Answer: Looooooong. 🔬 by @stjuderesearch.bsky.social graduate student Christina Wang. 🟣 marks the membrane of a cultured fibroblast. 🧪

A confocal micrograph of a cell with a very long cellular protrusion called a cytoneme.

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Journal of Cell Biology @jcb.org · 11/09/2026

Gourkanti et al. @neal-lab.bsky.social show that the rhomboid protease Rhbdl2 restrains #macrophage recruitment & wound repair in #zebrafish, positioning Rhbdl2 as a potential brake on macrophage-driven repair rupress.org/jcb/article/... #Migration #motility #Immunology

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Timothée Lionnet @successprocess.bsky.social · 11/09/2026

Sharing ZATELLITE 🛰️ - a tool to visualize and manipulate repetitive loci in living cells using designer zinc fingers tinyurl.com/ZATELLITE led by Nestor Saiz, collab with Marcus Noyes, @teresadavoli.bsky.social, @glennislogsdon.bsky.social, @liamholt.bsky.social & @jefboeke.bsky.social (1/n)

principle of ZATELLITE: synthetic Zinc Fingers are fused to a fluorescent protein and targeted to repetitive endogenous sequences - this ensures damage-free tagging, which is not the case with dCas9

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Eugene Katrukha 🇺🇦 @ekatrukha.bsky.social · 11/09/2026

I'm always very happy to see the #Fiji gang & co, this time during the OME-Zarr Java hackathon in Dresden (imglib2/BDV motherland?). My personal progress: increasing max # of volumes in #BigVolumeViewer from 15 to ~200. Still not high enough, but there was not enough time.

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Memorial Sloan Kettering Cancer Center @mskcancercenter.bsky.social · 11/09/2026

MSK researchers are using AI to design better proteins for CAR T cell therapy. In mouse models, an AI-designed binder from Dr. Caleb Lareau's lab controlled tumor growth significantly better than binders used in FDA-approved CAR T therapy targeting BCMA. Learn more: bit.ly/4cGeaSc

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Anh Hoang Le, PhD 🏳️‍🌈🏴󠁧󠁢󠁳󠁣󠁴󠁿🇻🇳 @anhhle2702.bsky.social · 11/09/2026

Here is the full clip of an embryonic myeloid cell transiting from inside to outside of an explant. It's one of my most favorite clips. Note how the nucleus 🔵 is squeezed right at the tissue boundary, and the myosin signal 🔴 goes from rearward to randomly distributed. How cool? #FluorescenceFriday

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Rockefeller University Press @rupress.org · 08/09/2026

In @jcb.org, Qian, Good et al. determine that proper spatial patterning of zygotic genome activation is required for #embryogenesis and the existence of a surveillance system for embryo quality control exquisitely tuned to spatiotemporal ordering of genome activation. rupress.org/jcb/article/...

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Anh Hoang Le, PhD 🏳️‍🌈🏴󠁧󠁢󠁳󠁣󠁴󠁿🇻🇳 @anhhle2702.bsky.social · 07/09/2026

18/n: Moving on, I'm looking for a (short) 2nd postdoc to explore deeper immunobiology. I want to explore more complex in vitro systems, #3D culture, and #mechanobiology which I think will benefit me in the long run. So if you know of such opportunities, please do let me know! Thank you. End 🧵.

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Anh Hoang Le, PhD 🏳️‍🌈🏴󠁧󠁢󠁳󠁣󠁴󠁿🇻🇳 @anhhle2702.bsky.social · 07/09/2026

Very happy to share my postdoc paper is out now in @natcellbio.nature.com titled "Tissue flow acts as a guidance cue for immune cell polarization and directional migration". If you love imaging and immune cells, this is for you! #microscopymonday www.nature.com/articles/s41... A 🧵: 1/n

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Eugene Katrukha 🇺🇦 @ekatrukha.bsky.social · 04/09/2026

A very persistent, tireless cowboy! Very pretty choanoflagellates, imaged today on LLS together with Babette van Amen from @agathechaigne.bsky.social lab.

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Anh Hoang Le, PhD 🏳️‍🌈🏴󠁧󠁢󠁳󠁣󠁴󠁿🇻🇳 @anhhle2702.bsky.social · 04/09/2026

Immune cells are fascinating 🤩 . Here, an embryonic myeloid cell (pre tissue-resident mac) ( 🔴 ) is seen in its (almost) natural tissue environment ( 🔵 ) of ectodermal cells. The cell is in a 2.5D-3D environment and looks it is being "swallowed up" by the surrounding cells 😁. #FluorescenceFriday.

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Guillaume Jacquemet @guijacquemet.bsky.social · 04/09/2026

🚨New preprint alert 🚨 "Pancreatic cancer cells breach endothelial barriers through protrusion-driven invasion or endothelial retraction" www.biorxiv.org/content/10.6...

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Ben Martin @benjaminmartin.bsky.social · 04/09/2026

Come be my colleague! Montreal is a great place to live and work! Tenure Track position at @mcgill.ca in quantitative cell biology with a research program to address fundamental questions in biology. @futurepislack.bsky.social mcgill.wd3.myworkdayjobs.com/McGill_Caree...

mcgill.wd3.myworkdayjobs.com

Assistant Professor in Quantitative Cell Biology - Department of Biology

Please refer to the How to Apply for a Job (for External Candidates) job aid for instructions on how to apply. If you are an active McGill employee (ie: currently in an active contract or position at ...

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International Society of Developmental Biology @isdb.bsky.social · 04/09/2026

If you're looking for your next job, and would like to connect with your peers, or just simply want to get your name out there, this is a good opportunity 👏👏. #networking

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Development @dev-journal.bsky.social · 04/09/2026

A developmental biologist's guide to mechanics Read this Primer from our special issue #DevSIextracellular by Jialing Cao, @raphclement.bsky.social, @pflenne.bsky.social and colleagues. journals.biologists.com/dev/article/...

Intracellular force-generating mechanisms drive tissue-scale mechanical behaviors. The central schematic provides an overview of the major cellular force-generating mechanisms in developing tissues and serves as the basis for the four surrounding panels, which illustrate how these mechanisms generate distinct tissue-scale mechanical behaviors. It includes actomyosin contractility, actin polymerization, cell–cell adhesion and ion transport through membrane channels. These processes generate and transmit forces within and between cells. (A) ATP-dependent ion transport establishes an osmotic pressure difference (ΔP), driving water influx into the lumen. Black radial arrows indicate the outward mechanical effect of the luminal pressure during lumen expansion. (B) Actin polymerization at the tissue edge generates protrusive forces that drive coordinated, directional collective cell migration. Here, leading edge refers to the advancing front of a moving cell group, featuring specialized lead

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International Society of Developmental Biology @isdb.bsky.social · 04/09/2026

If you're an #ECR or know someone who has recently published a paper/preprint/manuscript in the field of #devbio, #cellbio, #compbio, #mechanobiology, #evodevo, and would want to get the words out there, our DM is always open 🥰! We think all #ECRs deserve the recognition for their hard work.

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Cells & Development @cellsdev.bsky.social · 04/09/2026

Vora and Rosin et al shows that CSF1R signalling is not only important in monocyte development but its in utero inhibition in 🐭 significantly affects cranioskeletal and muscle development, such as the mandible and the shape of their tongue. #devbio www.sciencedirect.com/science/arti...

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Development @dev-journal.bsky.social · 03/09/2026

Break to build: fracture as a unifying morphogenetic strategy Read this Review from our special issue #DevSIextracellular by Daniel Santos-Oliván, @rashmi-priya.bsky.social, @torres-sanchez.bsky.social & co. journals.biologists.com/dev/article/...

$Five-panel schematic showing examples of tissue fracture in living systems. (A) In Trichoplax, movement builds local strain that leads to body fracture. (B) In sea anemones, pedal laceration leaves tissue fragments that adhere to the substrate and develop into new individuals. (C) In Hydra, tissue movements create a narrowing ("waist"), localised strain accumulates, and rupture produces fission. (D) In zebrafish embryos, mechanical tension generated by contact between tissues and actomyosin contraction drives rupture to form the nostril opening. (E) In the embryonic heart, repeated stretching causes fractures in the cardiac extracellular matrix (cECM), with damage concentrating in regions of high strain. Arrows indicate movement or pulling forces; red annotations highlight strain, rupture, or tissue fragments.$

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Development @dev-journal.bsky.social · 03/09/2026

Mechanics of compression-driven morphogenesis Read this Review from our special issue #DevSIextracellular by Jue Yu Kelly Tan and Chii Jou Chan. journals.biologists.com/dev/article/...

Modulation of tissue dynamics by compressive stress during development. (A) Mouse ovarian follicle growth requires contractile theca cell activity and confinement by the extracellular matrix (ECM) to regulate intrafollicular pressure, which, in turn, balances granulosa cell division (yellow) and death (purple). Arrows indicate compressive stress. (B) The Drosophila leg disc is mechanically confined by the peripodial envelope, which induces compressive stress buildup (arrows) and eventually cell apoptosis at the distal tip. (C) Differential planar growth in the Drosophila wing imaginal disc pouch generates a heterogenous mechanical stress field (arrows), with tensile stresses in the peripheral cells (green) and compressive stress in the central cells (blue). These stresses regulate cell division patterns. (D) During Arabidopsis anther lobe formation, faster growth in the inner lobe (single arrows) causes pressure buildup, causing the lobe epidermis to stretch (double arrows). (E) In the zebrafish follicle, rapid expansion of the future micropyle precursor cell mechanically compresses the adjacent granulosa cells, inducing nuclear export of TAZ in the granulosa cells. This restricts micropyle precursor fate to a single cell through mechanical lateral inhibition. (F) In avian skin follicle patterning, dermal cell aggregation generates compressive forces on the overlying epidermis, inducing β-catenin translocation from the membrane to the nucleus and initiating feather follicle fate specification. (G) Cephalic furrow formation during Drosophila gastrulation serves as a pressure-relieving transient fold that dissipates excess compressive stress generated from tissue collisions between the head and trunk (germ band) extension. (H) Growth under confinement generates internal compressive stresses in Escherichia coli biofilms that drive surface buckling and wrinkle formation.

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Cells & Development @cellsdev.bsky.social · 28/08/2026

A very intriguing story by Joao F. Botelho et al shows that in bird, the digit formation (their ✋) is not only governed by apoptosis but also due to changes in the rate of growth extension and cell division between the interdigital zone and the digital zone. So cool! #devbio doi.org/10.1016/j.cd...

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International Society of Developmental Biology @isdb.bsky.social · 28/08/2026

An interesting paper by @katecavanaugh.bsky.social shows that aged embryos have higher contractility than younger ones, which impedes their spreading and attaching during implantation. Potential to help with embryo screening! 👉Also, she's on the job market right now!👈 👇👇👇 doi.org/10.1038/s415...

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Cells & Development @cellsdev.bsky.social · 28/08/2026

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