Abstract. Translation initiation involves a concerted set of intermolecular interactions that efficiently recognize optimal AUG start codons. However, tran

Duchenne muscular dystrophy (DMD) is a fatal disorder caused by loss of dystrophin, a protein essential for muscle cell integrity. To date, no therapeutic has restored full-length dystrophin. Suppress...

A new Northwestern Medicine study has identified a previously unknown mechanism by which an enzyme promotes cancer cell proliferation, establishing it as a promising therapeutic target for cancer, according to findings published in Nature Communications.

The mechanisms underlying the role of N-acetyltransferase 10 (NAT10) in cancer remain poorly characterised. Here, PROTAC-mediated degradation of NAT10 with a deep mutational scanning assay and functio...

Highly conserved mRNA 3′ UTRs act as co-translational chaperones for intrinsically disordered regions (IDRs), preventing inter-domain misfolding and enabling biogenesis of fully active proteins.

The kinase ZAK is activated at collided ribosomes to mediate the ribotoxic stress response.

The federal government froze the university’s research funding. It hasn’t offered the school a way to get it back.

The Trump administration’s freezing of $790 million in federal research funding for Northwestern University has left concerned lab directors without key grants and forced the university to spend mi…

Cancer cells frequently enhance ribosome production to support rapid growth. Here, Lee et al. demonstrate that an isoform of lncRNA CRNDE containing an ultraconserved element (CRNDEUCE) promotes 60S r...

YouTube video by KING 5 Seattle

National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.

To maintain translational fidelity, cells degrade decoding-incompetent ribosomes through the 18S nonfunctional rRNA decay (NRD) pathway. Coria et al. demonstrate that the concerted actions of GCN2, RNF10, and RIOK3 lead to a block in translation…

Research Assistant/Associate - Regulation of gene expression

The CCR4-NOT complex is a major regulator of eukaryotic messenger RNA (mRNA) stability. Slow decoding during translation promotes association of CCR4-NOT with ribosomes, accelerating mRNA degradation....

The 2025 Gordon Research Conference on Decoding Microproteins Across Evolution and Disease will be held in Castelldefels, Barcelona Spain. Apply today to reserve your spot.