iiinova — where your digital self keeps evolving

Reposted by Mara Mueller

Stefano Giandomenico @sgiando.bsky.social · 22h

Can a brain organoid grown in a dish build synapses that resemble the real thing at the molecular level? 🧠 We grew mouse forebrain organoids for 35 days and compared their synaptic proteome to that of the adult mouse cortex 🧪 www.biorxiv.org/content/10.6... 🧵 1/5

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Reposted by Mara Mueller

joe dobbs @joedobbs.bsky.social · 25/09/2026

Our work investigating the cooperation between gene expression machines is now online @cellpress.bsky.social. Check it out if you're interested in high-throughput #cryoET, transcription and translation, or using structural biology to quantify gene expression in cells! 🔬 www.cell.com/cell/fulltex...

cell.com

Single-cell visual proteomics of a minimal bacterium reveals structural coordination of gene expression machineries

Cryo-electron tomography (cryo-ET) resolves and quantifies an almost complete view of bacterial translation, revealing how gene expression machineries coordinate across the processes of transcription,...

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Reposted by Mara Mueller

Maria Barna @mbarnalab.bsky.social · 25/09/2026

Last chance to register for the ribosome heterogeneity and translation control meeting. Selected talks from abstracts and an excellent lineup of speakers! Please repost and register today!

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Reposted by Mara Mueller

Caitie McCafferty @computingcaitie.bsky.social · 09/09/2026

I am looking for a lab manager for my group that I will be starting at the @fmiscience.bsky.social in February! We will use in situ structural biology to investigate dynamic ciliary processes. More info here —> bsky.app/profile/comp... #cilia #teamtomo #proteomics #protistsky

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Reposted by Mara Mueller

Teresa Spanò @teresaspano.bsky.social · 03/08/2026

Happy that our research on mRNA localization, synaptic diversity and local protein synthesis in layer 1 is now out in Cell Reports! 🧬🧠 Read it in full here 👉 doi.org/10.1016/j.ce... and browse the data here 👉 syndive.org @cp-cellreports.bsky.social @mpibrain.bsky.social

doi.org

Redirecting

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Reposted by Mara Mueller

Simone (she/her) @simonerencken.bsky.social · 31/05/2026

I’m happy to share that our paper about the Sepia officinalis genome is out in eLife!🧬 We compared the assemblies of two individuals that had a different predicted number of chromosomes, and found highly repetitive regions that likely prevented a complete assembly. elifesciences.org/articles/107...

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Reposted by Mara Mueller

Journal of Cell Biology @jcb.org · 11/05/2026

Ultrastructure of dopaminergic varicosities revealed by cryo-correlative light and electron microscopy. New study from Matthew Domenic Lycas (@lycasworks.bsky.social), Simon Erlendsson et al. @ucph.bsky.social: rupress.org/jcb/article/... #Neuroscience #Organelles #StructuralBiology #cryoCLEM

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Reposted by Mara Mueller

UCL Faculty of Brain Sciences @uclbrainscience.bsky.social · 29/04/2026

🎉 We’re delighted to announce Professor Erin Schuman, will become Director of the UCL Queen Square Institute (@uclqsion.bsky.social) from 1 Jan 2027. www.ucl.ac.uk/news/2026/ap...

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Reposted by Mara Mueller

qiangguo.bsky.social @qiangguo.bsky.social · 21/04/2026

The peer reviewed version is out. Our study suggests this process is not limited to a single dimer architecture: we identified an additional dimeric arrangement, pointing to greater structural diversity in stress-induced ribosome hibernation-like states. doi.org/10.1093/nar/...

doi.org

rRNA expansion segments mediate ribosome dimerization as a conserved stress response

Abstract. Inhibition of messenger RNA translation is a common feature in proteostatic stress cellular responses. Puromycin, a widely used compound for stud

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Reposted by Mara Mueller

Juan C. Landoni @jclandoni.bsky.social · 03/04/2026

Our paper is now out in Science! Super excited to share our discovery that #mitochondria #pearling is the elusive mechanism driving the regular distribution and inheritance of #mtDNA nucleoids 🧬 [1/6]

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Mara Mueller @muellermara.bsky.social · 25/02/2026

Even more hibernating dimers out there! A new preprint by @qiangguo.bsky.social shows oligomerization of inactive ribosomes is a mechanism shared across different expansion segments and stress conditions.

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Reposted by Mara Mueller

Max Planck Institute for Brain Research @mpibrain.bsky.social · 19/02/2026

Ribosomes in pairs: A survival strategy inside stressed cells. When nutrients drop or temperatures shift, cells switch to survival mode. New work by @erin-schuman.bsky.social & colleagues shows that inactive ribosomes pair up via a ribosomal RNA link @andschwarz.bsky.social @muellermara.bsky.social

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Mara Mueller @muellermara.bsky.social · 19/02/2026

Mammalian cells form hibernating disomes akin to those in bacterial cells - but connected via ribosomal RNA www.science.org/doi/10.1126/... co-first with: @andschwarz.bsky.social with: @lea-dietrich.bsky.social, @sgiando.bsky.social, @erin-schuman.bsky.social and many more 🧵 0/6 #MolBio 🧪

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Reposted by Mara Mueller

Teresa Spanò @teresaspano.bsky.social · 25/11/2025

I’m excited to share my PhD work on localized mRNAs and protein synthesis in cortical layer 1 on bioRxiv! www.biorxiv.org/content/10.1...

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Reposted by Mara Mueller

Jakob Meier-Credo @meiercredo.bsky.social · 19/09/2025

Check out our new preprint on an integrated pipeline combining in situ #cryo-ET with MALDI #MSImaging for single-cell identification and classification from previously analysed EM-grids. Link: www.biorxiv.org/content/10.1...

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Mara Mueller @muellermara.bsky.social · 28/04/2025

New Preprint out ! The proteasome maturation factor POMP moonlights as a stress-induced transcriptional regulator www.biorxiv.org/content/10.1... Lead by: @sgiando.bsky.social with: @muellermara.bsky.social , @erin-schuman.bsky.social , @marcvoo.bsky.social and many more Short thread below 🧵1/4

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