Genes & Immunity - Association of tumour-associated macrophage states with non-conserved lncrnas in lung cancer

The human cancer genome contains a substantial proportion of nonconserved regions that are transcribed into long noncoding RNAs (lncRNAs) and hosted in areas recurrently implicated in cancer. Due to i...

Original paper: [LINK] Video summary by Eleonora Leucci (KU Leuven) Cinque et al. demonstrate that inhibition of a cancer-specific transcript makes human drug-tolerant persister cells visible to…

Researchers at KU Leuven have identified an RNA molecule that enables melanoma to hide from the immune system. When this molecule is blocked, immune cells are once again able to detect and attack the ...

As biomedical research prioritizes human models and translational promise, classic model organisms are increasingly dismissed. Here we argue that they have a lasting value, both in enabling discovery and in cultivating scientific thinking, by training researchers in systems reasoning, integrative thinking and independent inquiry.

Abstract. Due to the heterogeneity of multi-omics data, exacting their maximum information potential remains a challenge. Whereas some solutions have been

Cell Death & Differentiation - The long non-coding RNA ROSALIND protects the mitochondrial translational machinery from oxidative damage

Nature Reviews Cancer - Resistance to therapy remains the biggest challenge to achieving cures in patients with cancer. In this Roadmap, Russo et al. overview the field of cancer drug-tolerant...