Very excited to share this work www.nature.com/articles/s41... by Mahmood Dalhat, Sharath Narayan, et al., and a great collaboration with the Konstantinos Tzelepis lab.
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@natcomms.nature.com
nature.com
The RNA helicase domain of NAT10 promotes the biogenesis of hypomodified ribosomes to enhance cancer cell proliferation - Nature Communications
The mechanisms underlying the role of N-acetyltransferase 10 (NAT10) in cancer remain poorly characterised. Here, PROTAC-mediated degradation of NAT10 with a deep mutational scanning assay and functio...