Sign in

DjuranovicLab at Brown University RNA Center

@djuranoviclab.bsky.social
968 followers 216 following 74 posts

RNA, Ribosome, miRNA, mRNA, translation, translational control, sometimes splicing

PostsRepliesMedia
DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · 20/09/2026
This is the first of multiple manuscripts that use our patented approach to increase protein production in gene specific way from a wild type allele in happloinsufficiencies using antisense oligonucleotides. Collaboration with Tim Miller lab. www.biorxiv.org/content/10.6...
031
DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · 20/09/2026
Sam Snyder from @djuranoviclab.bsky.social and Hugh Notman from Slavica Pavlovic Djuranovic's lab delivered great scientific talks at the recent CSHL Translational Control and Molecular Parasitology meeting in Woods Hole. You'll hear and read more about peptidyl-tRNA drop-off and prion like proteins
120
DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · 09/08/2026
Great news this morning, Amir Orian's and my lab received BSF funds for collaborative project on post-transcriptional control of cell identity for the next 4 years. Looking forward to this collaboration and joint project between Technion and Brown University.
020
DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · 10/07/2026
Notice of award from NIGMS for our R35 application on "Mechanisms of Translational Control" for the next 5 years. Nice way to celebrate a full year at Brown University and Giuliani RNA Center at Brown.
191
DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · 05/06/2026
It is a great privilege to be named Mencoff Family RNA Research Professor of Molecular Biology, Cell Biology and Biochemistry at Brown University. I am grateful to Mencoff Family, Brown University, Department of Molecular Biology, Cell Biology, and Biochemistry and Guiliani RNA Center.
090
DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · 25/03/2026
Our RAPPL international patent application has just been published.
020
DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · 18/03/2026
Visit from a friend and great colleague from Newcastle University. Sergey Melnikov will after snowy February in Providence talk tomorrow about hibernating ribosomes. Another talk at Brown RNA Center. #ribosomes #RNA
070
DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · 05/12/2025
Great collaboration with Dougherty and Pavlovic Djuranovic labs on using MPRAs to look into non-coding mutations. Approaches for identification of 5′ UTR mutations impacting translation and protein production from neurodevelopmental disorder genes www.sciencedirect.com/science/arti...
sciencedirect.com
Approaches for identification of 5′ UTR mutations impacting translation and protein production from neurodevelopmental disorder genes
Coding mutations can cause neurodevelopmental disorders (NDDs), including autism. Yet, predicting which non-coding (e.g., 5′ untranslated region [UTR]…
062
DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · 24/10/2025
On the way back from one week of great science, technology and therapeutic potentials of RNA in organization of Immagina Biotechnology S.r.l. and Massimiliano Clamer. Thanks for the great meeting to Max and the Immagina team. Looking forward to future collaborations. #RNA #tRNA #ribosome
040
DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · 29/09/2025
A short synopsis of a recent Symposium at Brown University and inaugural Giuliani RNA Center meeting. It was an honor to be part of it. www.brown.edu/news/2025-09...
brown.edu
Researchers, industry leaders convene at Brown to explore the potential of RNA
Brown’s Giuliani RNA Center and the Rhode Island Life Science Hub co-hosted a symposium focused on how scientists can work together to turn RNA discoveries into solutions.
020
DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · 14/09/2025
We are looking for a new postdoctoral fellow interested in the further development of our RAPPL technology and studies of translational complexes. Preference will be given to candidates with either structural biology or ribosome profiling backgrounds. www.nature.com/articles/s41...
nature.com
A rapid, simple, and economical method for the isolation of ribosomes and translational machinery for structural and functional studies - Nature Communications
Here, the authors present a method to rapidly isolate actively translating ribosomes in a time- and cost-effective manner using poly-lysine. The method is compatible with a wide variety of cell and ti...
065
DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · 11/09/2025
Please join us for the Inaugural Brown RNA Center Symposium with a Keynote Speakers Melissa Moore and Craig Mello, guests Victor Dzau, Jack Reed and Subra Suresh, as well as more talks and panels including both scientific and industrial speakers and panelists. sites.brown.edu/rna-symposium/
sites.brown.edu
RNA Without Borders: Academic Insights, Industry Impact
Join research and industry leaders in RNA science for a dynamic symposium uniting cutting-edge innovation with real-world solutions for the health of people and planet. September 26-27, 2025The Warren...
030
DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · 03/09/2025
Four days of science at @events.embl.org in Heidelberg for "Protein Synthesis and Translational Control" meeting.
061
DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · 05/08/2025
Our RAPPL purification of ribosomes and associated material is out. I am really proud of this study in collaboration primary with Pavlovic-Djuranovic lab, as well as Jovanovic and Hashem Labs. This method aims to replace 60 years old purification of ribosomes by sucrose cushions rdcu.be/ezlhg
rdcu.be
A rapid, simple, and economical method for the isolation of ribosomes and translational machinery for structural and functional studies
Nature Communications - Here, the authors present a method to rapidly isolate actively translating ribosomes in a time- and cost-effective manner using poly-lysine. The method is compatible with a...
15221
DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · 25/07/2025
Our collaboration with Tony Mustoe's lab us out today. MPRA libraries and possible cryptic splicing in MPRA reporters, or reporters in general. The additional novelty here is that such events are controlled or influenced by AU-rich sequences. www.nature.com/articles/s41...
nature.com
U-rich elements drive pervasive cryptic splicing in 3’ UTR massively parallel reporter assays - Nature Communications
Massively parallel reporter assays (MPRAs) are powerful technologies for measuring the impact of non-coding sequences on gene expression. Here, the authors demonstrate that MPRA reporters often underg...
02918
DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · 15/07/2025
First RAPPL ribosome isolation at the new lab space at Brown University. Purification from a small culture of parasitic Eukaryote. Soon out... www.biorxiv.org/content/10.1...
040
DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · 01/07/2025
@djuranoviclab.bsky.social is from today officially part of Brown University and Brown RNA center. We will have our new website soon. rna.brown.edu
rna.brown.edu
The Brown RNA Center | Medical School | Brown University
Our mission is to advance RNA science through fundamental discovery, technology development, and translational impact that accelerates life-changing health solutions.
1101
DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · 08/05/2025
Last month @uspto.bsky.social issued yet another patent to Slavica Pavlovic Djuranovic, Jessey Erath and @djuranoviclab.bsky.social for use of polybasic peptide or non-peptide moieties against malaria parasites. More soon...
020
DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · 28/04/2025
Some of the ribosomes purified using RAPPL and Cryo-EM structures solved in last couple of months (6/6). Archaea #1 www.biorxiv.org/content/10.1...
000
DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · 28/04/2025
Some of the ribosomes purified using RAPPL and Cryo-EM structures solved in last couple of months (5/6). Eukaryotic #3 www.biorxiv.org/content/10.1...
010
DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · 28/04/2025
Some of the ribosomes purified using RAPPL and Cryo-EM structures solved in last couple of months (4/6). Eukaryotic #2 www.biorxiv.org/content/10.1...
000
DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · 28/04/2025
Some of the ribosomes purified using RAPPL and Cryo-EM structures solved in last couple of months (3/6). Eukaryotic #1 www.biorxiv.org/content/10.1...
000
DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · 28/04/2025
Some of the ribosomes purified using RAPPL and Cryo-EM structures solved in last couple of months (1/6). Bacterial #2 www.biorxiv.org/content/10.1...
000
DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · 28/04/2025
Some of the ribosomes purified using RAPPL and Cryo-EM structures solved in last couple of months (1/6). Bacterial #1 www.biorxiv.org/content/10.1...
000
DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · 18/04/2025
This was a fun collaboration with Maxim Arttyomov lab on how itaconate inhibits the active site of a peroxiredoxin enzyme. Thanks Maxim for including us in this. www.nature.com/articles/s42...
nature.com
Itaconate modulates immune responses via inhibition of peroxiredoxin 5 - Nature Metabolism
Itaconate is shown to non-covalently inhibit the antioxidant enzyme peroxiredoxin 5 in macrophages, thereby modulating the production of mitochondrial peroxide and enhancing the type I interferon prod...
010
DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · 14/04/2025
Ready for the next RNA session in @asbmb.bsky.social meeting. We start soon...
083
DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · 28/03/2025
Ribosome data collected from a new and precious sample of 10,000,000 cells from a strange organism. All done using RAPPL, more soon... www.biorxiv.org/content/10.1...
080
DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · 23/03/2025
3 years after terrible loss (two -80C freezers and all back-ups) of almost all of our collection of regular and mutant human, Drosophila, E. Coli and Plasmodium cells, we are still not finished with insurance.
110
DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · 21/02/2025
One of the best single step purification preparations of protozoan ribosomes I've ever seen. Combination of RAPPL (biorxiv.org/content/10.1...) and a new technique. More at rna.ucsc.edu/rnacenter/ri...
130
Reposted by DjuranovicLab at Brown University RNA Center
Frances Yap @ribo1214.bsky.social · 18/02/2025
🚨The triennial Ribosome Conference will be held June 22-June 27, 2025 in Pacific Grove, California. Registration is open - hope to see many #Ribosome #RNA aficionados there. #RNASky #AcademicSky 🧪 rna.ucsc.edu/rnacenter/ri...
rna.ucsc.edu
Ribosomes2025 Program
The Ribosome Conference is held every three years and brings together researchers working on all aspects of the ribosome, from structure and function to its role in disease and use as a drug target.
02114
DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · 14/02/2025
Ok after @cryoclem.bsky.social we also tried Archaeal ribosomes (and some proteasomes) with RAPPL (www.biorxiv.org/content/10.1...) as well as some specific translation cycle complexes with new method.
040
DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · 12/02/2025
After RAPPL (www.biorxiv.org/content/10.1...) we found another way to get ribosomes and other macromolecular complexes easier to the cryoEM grids. This time besides ribosomes p97 complexes were purified (back to the PhD times). Stayed tuned...
061
DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · 31/01/2025
As I noted more to come from RAPPL (www.biorxiv.org/content/10.1...)
010
DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · 30/01/2025
In addition to today's posted work by @cryoclem.bsky.social on Archaeal ribosomes we further expanded RAPPL (www.biorxiv.org/content/10.1...) on multiple other complexes that work with ribosomes, subunits or even off the ribosome. Soon more...
041
DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · 30/01/2025
Thanks for sharing!
010
DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · 18/01/2025
Some translating but stalled bacterial ribosomes. Tandem purification using RAPPL. Ready for cryoEM...
070
DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · 12/01/2025
We are down to 2.32A and 2.61A for these specific ribosome complexes using tandem purification using RAPPL and tagged protein enrichment. In this case it was and hour and 45 minutes prep and 20-50 ml bacterial culture. www.biorxiv.org/content/10.1...
1166
DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · 20/12/2024
When your cryoEM run and data collection is not finished but still shows what you were looking for. Another one from 2ml culture.
040
DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · 16/12/2024
More ribosome structures solved by RAPPL (collaboration with Pavlovic Djuranovic and Hashem Labs). This one is bacterial from 2ml culture and using method described in our preprint. www.biorxiv.org/content/10.1...
03917
DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · 13/12/2024
As I mentioned before, from July 2025 our lab and lab of Slavica Pavlovic Djuranovic will be joining newly formed RNA Center at Brown University. Our labs will be in the Department of Biochemistry and Department of Pathology and Laboratory Medicine. Here is the link for RNA center. rna.brown.edu
rna.brown.edu
The Brown RNA Center | Medical School | Brown University
Our mission is to advance RNA science through fundamental discovery, technology development, and translational impact that accelerates life-changing health solutions.
170
DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · 11/12/2024
Congratulations to Dr.Courtney Jungers for successful PhD defense. Another PhD from @djuranoviclab.bsky.social
030
DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · 05/12/2024
Bye Tokyo and Japan till next meeting. This was such a great experience. Greetings to all great scientists that we met over the last three weeks in Japan.
010
DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · 03/12/2024
Second day of Ribosome meeting at the University of Tokyo. With Slavica Pavlovic Djuranovic.
030
DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · 30/11/2024
With 2/3 RNA conferences done (tRNA 2024 and MBSJ 2024) we are leaving beautiful Kanazawa, Shirakawa-go and Fukuoka and we are heading to Tokyo and meeting on ribosomes at University of Tokyo. Again thanks to all hosts.
190
DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · 20/11/2024
More RAPPL isolated ribosome complexes. Some are less complexed (first two images) same are more (last two images) complexed samples. Soon more input on these ones. Collaboration with Slavica Pavlovic Djuranovic and Yaser Hashem labs. #RNA #RNABiology #Ribosome
1121
DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · 19/11/2024
More from early morning walks in Kanazawa, and just before scientific sessions in tRNA meeting. #tRNA #RNA
020
DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · 17/11/2024
Morning walk through Kanazawa.
021
DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · 15/11/2024
Kanazawa and tRNA meeting, here I come. Hope to see a lot of new and also usual people there.
010
DjuranovicLab at Brown University RNA Center @djuranoviclab.bsky.social · 13/11/2024
This one is a great collaboration with @astratman.bsky.social on characterization of U12-spliceosome gene ZCRB1, U12-intron splicing and its role in ciliogenesis and WNT-signaling. Halloween passed but we can still get headless zebrafish. #RNA #splicing #RNAbiology www.biorxiv.org/content/10.1...
072
Reposted by DjuranovicLab at Brown University RNA Center
Jamie Cate @jhdcate.bsky.social · 13/11/2024
One of the most ancient sequences in biology, the peptidyl transferase center of the ribosome, is not as conserved as we might have thought. #RNA #Ribosomes www.biorxiv.org/content/10.1...
biorxiv.org
Structure of an Archaeal Ribosome with a Divergent Active Site
The ribosome is the universal translator of the genetic code and is shared across all life. Despite divergence in ribosome structure over the course of evolution, the peptidyl transferase center (PTC)...
110645