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Ryan Boileau

@bffswithbiology.bsky.social
1K followers 1.7K following 91 posts

NIH-F32 Postdoctoral Fellow @ChoryLab @DukeCAGT Chromatin, SynBio, Automation PhD @UCSF | #FirstGen | Nice to meet you friend☀️🌲😊

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Reposted by Ryan Boileau
Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 7h
Beautiful work, congrats to all @juliazeitlinger.bsky.social Now in @natcomms.nature.com www.nature.com/articles/s41...
nature.com
High-resolution binding data of TFIID and cofactors show promoter-specific differences - Nature Communications
Here, the authors use ChIP-nexus to map all TFIID subunits and cofactors across the Drosophila genome at base pair resolution, revealing a general TFIID organization across promoter types with promote...
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Nicole Rust @nicolecrust.bsky.social · 05/10/2026
A basic-basic-translational trifecta! A discovery in alga leads to a new technology that transforms both neuroscience research and leads to a brand new type of human therapy. I love that everyone in my feed is smiling this morning. Congrats, @deisseroth.bsky.social.
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David Shiffman, Ph.D. 🦈 @whysharksmatter.bsky.social · 24/09/2026
Have you ever tried to read a scientific journal article and been told “you don’t have access, pay to download this article?” Did you know that the author of that article gets $0 if you pay? Instead, you can email the author and ask for a free copy! I’d be delighted to help and answer questions!
Screenshot of a scientific journal paywall
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Emma R Andersson @anderssonlab.bsky.social · 23/09/2026
🧬 Preprint! 🧵 Our goal is to genetically manipulate every embryonic germ layer to enable high throughput in vivo studies. We previously showed mouse ectoderm can be targeted by amniotic injection, enabling cell-specific manipulation, lineage tracing, and knockouts. But how to reach mesoderm?
Schematic of method developed and application. At embryonic day 7.5, a lentiviral library carrying unique 30-nucleotide barcodes and a fluorescent reporter is injected into the mouse exocoelomic cavity. An E8 embryo cross-section shows that this cavity is continuous with the intraembryonic coelomic cavity, allowing the virus to reach and barcode mesodermal progenitors, including lateral plate and paraxial mesoderm.
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Harmit Singh Malik @harmitmalik.bsky.social · 24/09/2026
Some random thoughts: Good science doesn't always need disruptors. Often, it needs load-bearing walls. You can't pivot away from a failed multi-year experiment or "iterate" your way out of a mentee's PhD. Science needs stable foundations, not churn. Don't break the people building on top of it.
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Harmit Singh Malik @harmitmalik.bsky.social · 23/09/2026
Then and Now: The Rapid Evolution of Harmit Malik www.the-scientist.com/then-and-now...
the-scientist.com
Harmit Malik Dives Into Viral Evolution and Speciation | The Scientist
Fascinated by evolution and driven by curiosity, Malik studies everything from viruses to Drosophila and, like his research subjects, is constantly reinventing himself.
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Alex Wenzel @alexwenzel.bsky.social · 22/09/2026
For every one of these men who get a dramatic front page story, there are 25-50 postdocs who leave the country much less voluntarily.
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Alex Merz 🇺🇸🇨🇦🇺🇦 @merz.bsky.social · 22/09/2026
This. So much this! "These advances make it tempting to equate experimental cataloguing and accurate prediction with the growth of our theoretical understanding of biological processes – an equivalence we believe is ultimately misleading."
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allen institute @alleninstitute.org · 22/09/2026
Meet the 2026 cohort of Next Generation Leaders. This program recognizes emerging early career researchers in bioscience and is designed to foster community, exchange of ideas, innovation, and collaboration to make a broad, transformational impact on the future of science.
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Laura Grima @lauragrima.bsky.social · 22/09/2026
Grateful to have been selected as an Allen Institute Next Generation Leader - and for the opportunity to learn from and engage with this wonderful community!
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Leslie B Vosshall PhD @leslievosshall.bsky.social · 18/09/2026
Transformative opportunity for early career faculty @hhmi-science.bsky.social #FreemanHrabowski Scholars competition opens 11/3/2026 but you can get started NOW: view application components, establish eligibility, and unlock example applications and other resources www.hhmi.org/programs/fre...
hhmi.org
Early Career Faculty Program | Freeman Hrabowski Scholars | HHMI
The Freeman Hrabowski Scholars Program offers comprehensive support to outstanding early career faculty committed to scientific excellence in their own research, and to fostering labs that expand the ...
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A Jean Stevenson @amandajean.bsky.social · 09/09/2026
We are punishing people for having devoted their lives to helping us all.
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Harmit Singh Malik @harmitmalik.bsky.social · 08/09/2026
Completing the Connectome: How Pursuing a Map of the Fly Brain Rewired Neuroscience (Really worth sharing this video with your science-curious middle and high schoolers) www.hhmi.org/news/scienti... www.youtube.com/watch?v=2uMQ...
hhmi.org
Completing the Connectome: How Pursuing a Map of the Fly Brain Rewired Neuroscience | HHMI
Janelia scientists and collaborators have completed a wiring diagram of the central nervous system of an adult male fruit fly, the culmination of nearly two decades of groundbreaking research.
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Marc A. Marti-Renom @mamartirenom.bsky.social · 03/09/2026
Latest preprint from the lab… what could be better than good science with good friends? 😊 @agneseloda.bsky.social @antonia-hauth.bsky.social @encent.bsky.social @heard65.bsky.social @heardlab.bsky.social www.biorxiv.org/content/10.6...
biorxiv.org
X-inactivation escapee domains are CTCF-cohesin independent chromatin compartments
X-chromosome inactivation involves chromosome-wide gene silencing accompanied by extensive chromatin changes, as well the loss of topologically associating domains. Yet discrete regions of the inactiv...
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Carl Zimmer @carlzimmer.com · 01/09/2026
UNC-Chapel Hill, Duke to combine herbaria, creating the third-largest university plant collection in the United States ncbg.unc.edu/2026/08/31/u...
ncbg.unc.edu
UNC-Chapel Hill, Duke to combine herbaria, creating the third-largest university plant collection in the United States - North Carolina Botanical Garden
The combined herbaria will create an unmatched archive for studying plant diversity in the southeastern United States (Chapel Hill, N.C.— Aug. 31, 2026) UNC-Chapel Hill and Duke University will unite....
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christine liu / two photon art @christineliu.art · 26/08/2026
Question for all the PIs out there… How much did you end up following the research plan / statement that you wrote about in your applications? Just curious for funsies
static.klipy.com
Huh Dog with Question Mark
Alt: Huh Dog with Question Mark
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allen institute @alleninstitute.org · 22/08/2026
For the first time ever, we're opening our doors to the public! On Sept. 19, you're invited to get up close to our groundbreaking open science. Explore our building, look in our labs, and have fun at our activity stations. 🎟️ Free but RSVP is required: bit.ly/3U52zpb
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Kevin K. Yang 楊凱筌 @kevinkaichuang.bsky.social · 20/08/2026
Binder design is nice and all, but here we have three agents sharing data and autonomously controlling a lab to design enzymes with shifted substrate scopes and high activity! @cobanbrooks.bsky.social @pascalnotin.bsky.social @philromero.bsky.social www.biorxiv.org/content/10.6...
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Prasad Jallepalli, MD, PhD @prasad.bsky.social · 20/08/2026
per the article, NSF is withholding $1 billion of its budget so that the money can go to a special White House project grant (and grand) theft in broad daylight
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Maxim Greenberg @maxvcg.bsky.social · 03/08/2026
Read this article, get excited, and come to the Epigenome Editing symposium! Marianne Rots, Charlie Gersbach, and Angelo Lombardo (all featured in the piece) will be there in person!! Registration only 50€, talks from abstracts, plus Paris 😜 @natureportfolio.nature.com www.nature.com/articles/d41...
nature.com
Epigenetic editing makes its mark
Researchers are rewriting the chemical tags on DNA and chromatin to tune gene expression.
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Gladstone Institutes @gladstoneinst.bsky.social · 30/07/2026
Benoit Bruneau will receive the American Heart Association's highest scientific honor in November. @americanheart.bsky.social @benoitbruneau.bsky.social
gladstone.org
American Heart Association Honors Benoit Bruneau with 2026 Distinguished Scientist Award
Bruneau, director of the Gladstone Institute of Cardiovascular Disease, will receive the association's highest scientific honor in November.
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Jay Shendure @jshendure.bsky.social · 30/07/2026
New preprint from Shendure Lab on Locus-Scale aka Long-@$$ MPRAs led by the amazing Abby McGee & @carinabiar.bsky.social Most MPRAs test ~300 bp fragments next to a promoter. But real enhancers are bigger, act combinatorially and from a distance. 1/n www.biorxiv.org/content/10.6...
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Nature Biomedical Engineering @natbiomedeng.nature.com · 28/07/2026
Happy to announce our July issue is live! www.nature.com/natbiomedeng... Please check out our editorial on biomedical engineering for women's health.
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Rita Strack @ritastrack.bsky.social · 28/07/2026
Really proud of this issue, especially the editorial! www.nature.com/articles/s41...
nature.com
Design with women in mind - Nature Biomedical Engineering
Biomedical engineers are poised to meet urgent unmet needs in women’s health. We share our excitement about research in women’s health and our plans to champion such advances in our pages.
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Rita Strack @ritastrack.bsky.social · 23/07/2026
I was just on my soapbox the other day about how important science journalism is. Now more than ever.
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Felipe Opazo @opazo.bsky.social · 02/07/2026
New paper! 🚀 A high-affinity anti- #mNeonGreen #nanobody turns #mNG into a #multifunctional Tag. @nanotag.bsky.social decided to openly share the #nanobody for research use. Not common, but we strongly believe well-defined reagents are key for reproducible science. We hope you find it useful! 💚
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Tim Mosca (he/him) @drosophilosophy.bsky.social · 29/06/2026
Hard at work on a Monday morning! CSHL fly students are making great progress dissecting late stages pupae and freeing the brain for various experiments! #cshldros26
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PlantEvolution 🌱🌾 @plantevolution.bsky.social · 29/06/2026
Well, that was neither how it was advertised nor how it was received by many…
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Rita Strack @ritastrack.bsky.social · 17/06/2026
If you love imaging metadata, do I have something for you -- Search, organize, aggregate and share image data with BioFile Finder (BFF) | Nature Methods share.google/9UxsAcpaWhbu...
share.google
Search, organize, aggregate and share image data with BioFile Finder (BFF) - Nature Methods
Nature Methods - Search, organize, aggregate and share image data with BioFile Finder (BFF)
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PlantEvolution 🌱🌾 @plantevolution.bsky.social · 13/06/2026
My comments on proposed OMB Rule "Regulation for Federal Financial Assistance", written from the perspective of someone who became a naturalized citizen 25 yrs ago bc he believed in the US as a country of exceptional openness, opportunity & merit-based advancement drive.google.com/file/d/14Bbb...
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Rita Strack @ritastrack.bsky.social · 23/05/2026
The MOSAIC paper is out in Nature Methods. For the record I went after this paper for *years* and was so happy when they sent it to me/us. www.nature.com/articles/s41...
nature.com
A multimodal adaptive optical microscope for in vivo imaging from molecules to organisms - Nature Methods
MOSAIC is a versatile multimodal microscope that allows seamless transition between various light-sheet, two-photon, label-free and super-resolution modalities. It is demonstrated in various systems r...
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Sholto David @sholtodavid.bsky.social · 22/05/2026
Earlier this week I posted an example of a fake western blot provided by ThermoFisher to demonstrate the validity of a p53 antibody. I considered it an amusing curiosity. In fact Thermo Fisher Scientific has systematically manipulated antibody validation data!
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Elphege Nora Lab at UCSF @elphegenoralab.bsky.social · 13/05/2026
Why can't we explain enhancer action despite 2 decades of chromosome conformation technologies? 😬 Our new study spearheaded by Leonid Mirny's group points to a flaw in our assumptions, and to a solution from physical principles By @timothyfoldes.bsky.social 💻& @karissalhansen.bsky.social 🧪 🧵👇
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Julia Lazzari-Dean @jlazzaridean.bsky.social · 12/05/2026
We invented “triplet tumbling microscopy” (TTM) to track protein-protein interactions in living cells! Tag your protein with GFP and see it interact with *untagged* binding partners www.biorxiv.org/content/10.6...
A cartoon overview of triplet tumbling microscopy, comparing data from bound and unbound samples.
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Elias Friman @eliasfriman.bsky.social · 11/05/2026
Is distal gene activation by enhancers inherently different from promoter-proximal activation? We propose not. But both cohesin and cooperativity are important aspects of how transcription is affected. Happy to share our recent preprint (thread below) 1/ www.biorxiv.org/content/10.6...
biorxiv.org
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Gladstone Institutes @gladstoneinst.bsky.social · 09/05/2026
Gladstone virologist Melanie Ott (@theottlab.bsky.social) breaks down what #hantavirus is, why the Andes strain is different from other hantaviruses, and how worried we should actually be.
youtube.com
Hantavirus Outbreak Explained: What a Virologist Wants You to Know
A hantavirus outbreak linked to a cruise ship is spreading across international borders, and it's raising serious questions about pandemic preparedness. Gladstone Institutes virologist Melanie Ott, MD, PhD, breaks down what hantavirus is, why the Andes ...
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Rita Strack @ritastrack.bsky.social · 09/05/2026
RNA-triggered cell killing with CRISPR–Cas12a2 | Nature share.google/eqXWN3MPz2NB...
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Harmit Singh Malik @harmitmalik.bsky.social · 21/04/2026
My lab is going to print these words and staple them to my forehead.
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Benoit Bruneau @benoitbruneau.bsky.social · 20/04/2026
important work from my @gladstoneinst.bsky.social and @ucsanfrancisco.bsky.social colleagues (also @harmitmalik.bsky.social!) on pro- and anti-HIV host factors. Just when you thought we couldn't do more! www.cell.com/cell/fulltex...
cell.com
Systematic discovery of pro- and anti-HIV host factors in primary human CD4+ T cells
Genome-wide CRISPR activation and knockout screens in primary human CD4+ T cells systematically identify host proviral and antiviral factors modulating HIV infection, including the strongly antiviral ...
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bioRxiv Bioinfo @biorxiv-bioinfo.bsky.social · 18/04/2026
Calibration of in-frame indel variant effect predictors for clinical variant classification www.biorxiv.org/content/10.64898/20…
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Alex Gao @algao.bsky.social · 16/04/2026
Excited to share our new findings in @science.org on how the DRT3 bacterial defense system uses a reverse transcriptase that builds DNA repeats without a nucleic acid template. Microbes never cease to amaze! www.science.org/doi/10.1126/...
science.org
Science | AAAS
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Harmit Singh Malik @harmitmalik.bsky.social · 16/04/2026
@hhmi-science.bsky.social's #FreemanHrabowski Scholars Program offers early career faculty up to $10M over 10 yrs, plus salary & benefits Stable, sustained support can transform your career: Senior Postdoc? This year's competition has a program for you too. Applications open 11/3! bit.ly/4vhC0LA
bit.ly
Early Career Faculty Program | Freeman Hrabowski Scholars | HHMI
The Freeman Hrabowski Scholars Program offers comprehensive support to outstanding early career faculty committed to scientific excellence in their own research, and to fostering labs that expand the ...
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HHMI @hhmi-science.bsky.social · 17/04/2026
“Being a #GilliamFellow has been the most life-changing experience of my career. The impact goes far beyond funding." A powerful letter to this year's potential applicants, from current Fellow Denethi Wijegunawardana. Read the full text on our Instagram, & bookmark 9/1 to apply! bit.ly/4sDHjlS
Current Gilliam Fellow Denethi Wijegunawardana pictured with Investigator & former HHMI President Tom Cech.
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BWJones @bwjones.bsky.social · 17/04/2026
I know at least 5 peeps w/NIH grants that have scored 1-4% who are not being funded. My hopes are those who are funded are using their resources to help others, particularly junior faculty. Sharing resources, personnel, time, etc… If we don’t all pull together, science and the country suffers.
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bioRxiv Cancer Bio @biorxiv-cancer.bsky.social · 17/04/2026
KDM6 Enzymes are the Mechanistic Targets of Mutant IDH that Dictate Replication Stress Sensitivity www.biorxiv.org/content/10.64898/20…
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Harmit Singh Malik @harmitmalik.bsky.social · 15/04/2026
If you hear of a graduate student who is being railroaded by their advisor and their thesis committee is not doing their job (which is to evaluate, correct, and protects the student’s interest, not your colleague’s) you can claim it’s not really your problem. But really you are part of the problem.
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Emma Chory, Ph.D. @chorye.bsky.social · 04/03/2026
Evolution navigated billions of challenges to get to us to where we are today. Directed evolution compresses this to a 1D axis. Imagine if you could sample 200 dimensions at once, with data to boot 📈 First @chorylab.bsky.social PACE preprint on our new system to tackle this: bit.ly/turboprance
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Ryan Boileau @bffswithbiology.bsky.social · 04/03/2026
Wahoooo it’s online!!! 🎉🥳 Excited to share a glimpse into my postdoc work with @chorye.bsky.social at Duke where @stefan-golas.bsky.social and I developed TurboPRANCE, a robotics platform to scale and enable new phage-assisted continuous evolutions. bskytorial party!👇 1/n
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NPR @npr.org · 04/03/2026
Sydney Peterson is among the U.S. athletes heading to the 2026 Winter Paralympics. A neuroscientist in training, Peterson is studying movement disorders, similar to her own condition. n.pr/3P0q28t
n.pr
As Paralympics approach, U.S. skier Sydney Peterson balances training and research
Sydney Peterson is among the U.S. athletes heading to the 2026 Winter Paralympics. A neuroscientist in training, Peterson is studying movement disorders, similar to her own condition.
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Dorien Pastoors @dpastoors.bsky.social · 21/01/2026
Rotation PhD student @emiliedevet.bsky.social in our lab made the Dish soap protocol work (on the first attempt) for a nuclear target with Dawn (the US version of dreft/fairy ) and thereby extended the dish soap protocol to a version for across the atlantic 🤩 @tothovalab.bsky.social #hemesky
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