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The Ott Lab

@theottlab.bsky.social
89 followers 31 following 12 posts

Melanie Ott's lab @ Gladstone Institutes studying host-viral pathogen interactions. Posts from lab members. Reposts are not endorsements.

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Reposted by The Ott Lab
Gladstone Institutes @gladstoneinst.bsky.social · 19/06/2026
New research emerging from the COVID-19 pandemic is revealing surprising connections between viruses, inflammation, and cancer progression. Gladstone Investigator Melanie Ott comments on these findings in the LA Times. @theottlab.bsky.social
latimes.com
What COVID is teaching doctors about the relationship between viruses and cancer
The pandemic has left some evidence that viral infection may play a role in reawakening dormant cancer cells already present in a patient's body before infection.
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Reposted by The Ott Lab
Gladstone Institutes @gladstoneinst.bsky.social · 02/06/2026
A team of Gladstone scientists—including Katie Pollard, Melanie Ott, Seth Shipman, and Sukrit Silas—will lead one of three new national centers dedicated to accelerating the development of phage therapy. @theottlab.bsky.social @seth-shipman.bsky.social
gladstone.org
Gladstone Launches Center for PhAIge Therapy to Harness AI in the Fight Against Drug-Resistant Infections
The center, funded by an NIH grant, will become one of three national centers dedicated to accelerating the development of phage therapy.
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Reposted by The Ott Lab
Seth Shipman @seth-shipman.bsky.social · 02/06/2026
We're launching a major collaborative Center aimed at accelerating phage therapy @gladstoneinst.bsky.social. High-throughput experiments with engineered phages (my lab) and strains (Silas Lab), organoids (Ott Lab), and AI (Pollard Lab). gladstone.org/news/gladsto...
gladstone.org
Gladstone Launches Center for PhAIge Therapy to Harness AI in the Fight Against Drug-Resistant Infections
The center, funded by an NIH grant, will become one of three national centers dedicated to accelerating the development of phage therapy.
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Reposted by The Ott Lab
Gladstone Institutes @gladstoneinst.bsky.social · 30/04/2026
🚨 NEW PUBLICATION🚨 "Programmable kinetic barcoding for multiplexed RNA detection with Cas13a" @natbiomedeng.nature.com @doudna-lab.bsky.social @theottlab.bsky.social www.nature.com/articles/s41551-026-…
nature.com
Programmable kinetic barcoding for multiplexed RNA detection with Cas13a - Nature Biomedical Engineering
A multiplexed RNA detection method exploits crRNA-dependent variability in Cas13a activity on RNA targets for kinetic barcoding and can be used to distinguish among SARS-CoV-2 variants in clinical sam...
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Reposted by The Ott Lab
Waggoner Lab @labwaggoner.bsky.social · 20/03/2026
Cell-extrinsic and -intrinsic mechanisms driving lymphocyte-mediated control of HIV rebound after ART interruption @cp-immunity.bsky.social @gladstoneinst.bsky.social #Roan @theottlab.bsky.social #Greene www.cell.com/immunity/ful...
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Reposted by The Ott Lab
Fletcher Lab @fletcherlabucb.bsky.social · 02/04/2026
In our new work published in @natbiomedeng.nature.com in collaboration with @theottlab.bsky.social and @doudna-lab.bsky.social, we introduce "interfering" guide RNAs (igRNA) for CRISPR-Cas13a that regulate enzyme activity after activation. Congrats to all the authors! www.nature.com/articles/s41...
nature.com
Programmable kinetic barcoding for multiplexed RNA detection with Cas13a - Nature Biomedical Engineering
A multiplexed RNA detection method exploits crRNA-dependent variability in Cas13a activity on RNA targets for kinetic barcoding and can be used to distinguish among SARS-CoV-2 variants in clinical sam...
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The Ott Lab @theottlab.bsky.social · 23/03/2026
We honor the life of J. Michael Bishop, whose groundbreaking discoveries helped transform our understanding of cancer and opened new paths for treatment. His legacy will continue to inspire generations of scientists and clinicians. Rest in peace.
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Reposted by The Ott Lab
Gladstone Institutes @gladstoneinst.bsky.social · 04/03/2026
Antiretroviral therapy transformed #HIV care—now we need a cure. Insights from Melanie Ott on what comes next.
bit.ly
Virologist Viewpoints: For HIV, ‘Manageable' Is No Longer Good Enough
Once a godsend, antiretroviral therapy is not what we should settle on. The time has come to finally cure HIV/AIDS.
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The Ott Lab @theottlab.bsky.social · 20/02/2026
Congrats, Nadia!
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Reposted by The Ott Lab
Gladstone Institutes @gladstoneinst.bsky.social · 02/12/2025
🚨 🚨 NEW PUBLICATION 🚨 🚨 "The Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2" from @theottlab.bsky.social in @elife.bsky.social
bit.ly
The Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2
The development of new small molecules demonstrates how pharmacologic inhibition of the coronavirus macrodomain restores innate immunity, leading to reduced viral replication and improved outcomes in ...
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The Ott Lab @theottlab.bsky.social · 24/11/2025
Tune in for our event on TikTok LIVE: “HIV Cure Lab Tour + Q&A"! 📆 Monday, December 1, 2025 at 10am PT 📍 Live on TikTok via @RaifDerrazi 🔗 Register: tiktok.com/live/event/7...
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The Ott Lab @theottlab.bsky.social · 01/10/2025
The Gladstone Institute of Virology has taken on a new name: the Gladstone Infectious Disease Institute. Check it out here: gladstone.org/news/beyond-...
gladstone.org
Beyond Viruses: Expanding the Fight Against Infectious Diseases
The newly renamed Gladstone Infectious Disease Institute broadens its mission to address global health threats ranging from antibiotic resistance to infections that cause chronic diseases.
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The Ott Lab @theottlab.bsky.social · 14/08/2025
Check out Dr. Melanie Ott's recent opinion piece on the SF Standard: sfstandard.com/opinion/2025...
sfstandard.com
With vaccine research under attack, it’s time for California to lead again
Halting mRNA research right now is like banning ChatGPT, writes infectious disease expert Melanie Ott — not just scientific negligence, but strategic self-sabotage.
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Reposted by The Ott Lab
UCSF Bakar ImmunoX Initiative @immunox.bsky.social · 05/08/2025
💉🧬 We're kicking off National Immunization Awareness Month with our faculty spotlight, Dr. Melanie Ott! Head to our Instagram to hear her take on how immunizations keep us safe—and how you can help to keep vaccines accessible for all: www.instagram.com/reel/DM_A9Sc... @theottlab.bsky.social
Portrait cutout of Dr. Melanie Ott with her name and credentials above the image. Text to the left of this reads “Faculty Spotlight.” The ImmunoX logo is in the top left corner on an indigo-purple background with two multicolored circles along the right side.Connect with Dr. Ott:

Website: https://ottlab.gladstone.org/
BlueSky: @theottlab.bsky.social‬
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The Ott Lab @theottlab.bsky.social · 29/07/2025
Congratulations Fran! @franzapatero.bsky.social
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The Ott Lab @theottlab.bsky.social · 17/07/2025
Congratulations to @juliaprigann.bsky.social for being awarded the 2025 CFAR Excellence in Basic/Translational Science Award! cfar.ucsf.edu/user/11703
cfar.ucsf.edu
Julia Prigann, PhD | UCSF-Bay Area Center for AIDS Research (CFAR)
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The Ott Lab @theottlab.bsky.social · 11/06/2025
We are delighted that we could help with this work. Check it out here: authors.elsevier.com/c/1lEffL7PXu...
authors.elsevier.com
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Reposted by The Ott Lab
Gladstone Institutes @gladstoneinst.bsky.social · 29/04/2025
Scientists from Gladstone and UCSF have developed drug candidates that could prevent future coronavirus pandemics. @theottlab.bsky.social @ucsfmedicine.bsky.social @qbi-ucsf.bsky.social
youtube.com
Discovery Spotlight | Could This Molecule Be ‘Checkmate’ for Coronaviruses?
Scientists from Gladstone and UCSF have developed drug candidates that could prevent future coronavirus pandemics. These molecules block a critical enzyme ne...
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Reposted by The Ott Lab
Gladstone Institutes @gladstoneinst.bsky.social · 23/04/2025
Scientists develop powerful drug candidates that could head off future coronavirus pandemics. @theottlab.bsky.social @ucsfmedicine.bsky.social @qbi-ucsf.bsky.social
gladstone.org
Could This Molecule Be ‘Checkmate’ for Coronaviruses?
Scientists develop powerful drug candidates that could head off future coronavirus pandemics.
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Reposted by The Ott Lab
Gladstone Institutes @gladstoneinst.bsky.social · 24/04/2025
🚨 NEW PUBLICATION 🚨 "Structure-based discovery of highly bioavailable, covalent, broad-spectrum coronavirus MPro inhibitors with potent in vivo efficacy" @theottlab.bsky.social @ucsfmedicine.bsky.social @qbi-ucsf.bsky.social
science.org
Structure-based discovery of highly bioavailable, covalent, broad-spectrum coronavirus MPro inhibitors with potent in vivo efficacy
This study describes a class of potent, bioavailable SARS-CoV-2 MPro inhibitors having an unusual mechanism of inhibition.
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Reposted by The Ott Lab
Gladstone Institutes @gladstoneinst.bsky.social · 10/04/2025
🎧 Listen to this podcast featuring virologist Melanie Ott. Ott discusses how measles works and the way it breaks into our body to make us sick. @theottlab.bsky.social
bit.ly
How does measles make us sick?
And the damage left in its wake...
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The Ott Lab @theottlab.bsky.social · 28/03/2025
Thank you to everyone who attended the HIV Mini-Symposium on March 13th! Our next Mini-Symposium will be September 23, 2025 titled 'Viral Landscapes: How to Comprehensively Monitor Evolutionary Trajectories'. We hope to see you there! www.youtube.com/watch?v=vjpe...
youtube.com
HIV Persistence: Where We Are Now and Where We Need to Go
YouTube video by QBI TV
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Reposted by The Ott Lab
Gladstone Institutes @gladstoneinst.bsky.social · 26/03/2025
Did you know that viruses don’t just infect humans—they also target bacteria in our microbiome? These viruses, called phages, play a crucial role in shaping our health and could be the key to fighting antibiotic-resistant bacteria. In this short, @theottlab.bsky.social explains.
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Reposted by The Ott Lab
Gladstone Institutes @gladstoneinst.bsky.social · 20/03/2025
Virologist Melanie Ott (@theottlab.bsky.social) speaks to KUSI News about the measles outbreak and other infectious diseases.
buff.ly
Gladstone's Dr. Melanie Ott speaks about measles, other infectious diseases on KUSI
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Reposted by The Ott Lab
Gladstone Institutes @gladstoneinst.bsky.social · 19/03/2025
At Gladstone, researchers are working toward curing HIV for good. Their work also sheds light on how viruses influence our long-term health. Melanie Ott, MD, PhD, director of the Gladstone Institute of Virology explains why curing HIV remains a crucial scientific challenge. @theottlab.bsky.social
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Reposted by The Ott Lab
Gladstone Institutes @gladstoneinst.bsky.social · 14/03/2025
What does the bird flu outbreak mean for public health? Virologist Melanie Ott (@theottlab.bsky.social) discusses how H5N1 in cows could affect virus evolution and why increased surveillance is important.
youtube.com
How Bird Flu in Cows Could Impact Public Health | Melanie Ott Explains
What does the bird flu outbreak mean for public health? Melanie Ott, MD, PhD, director of the Gladstone Institute of Virology, discusses how H5N1 in cows cou...
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Reposted by The Ott Lab
Gladstone Institutes @gladstoneinst.bsky.social · 13/03/2025
Melanie Ott talks about the ongoing measles outbreak, explains how vaccination can lower the risk of Alzheimer’s, and shares other positive “side effects” of vaccines. @theottlab.bsky.social
gladstone.org
Virologist Viewpoints: The Positive Side Effects of Vaccines
Melanie Ott talks about the ongoing measles outbreak, explains how vaccination can lower the risk of Alzheimer’s, and shares other positive “side effects” of vaccines.
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Reposted by The Ott Lab
Gladstone Institutes @gladstoneinst.bsky.social · 12/03/2025
In an interview with @amfarofficial.bsky.social, Melanie Ott (@theottlab.bsky.social), discusses the future of HIV research, and describes how lessons from the field have laid a strong foundation for fighting other viral diseases.
amfar.org
Shaping the Future of HIV Research
amfAR interviewed Gladstone Institutes’ Dr. Melanie Ott about her work on HIV, hepatitis C, and other viruses, and the promise of new technologies.
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Reposted by The Ott Lab
Gladstone Institutes @gladstoneinst.bsky.social · 07/03/2025
Gladstone recently hosted the German Center for Research and Innovation San Francisco for their Innovation Summit. The event addressed the challenge of sharing data across sectors, institutions, and borders, a key question for global health. Speakers included Melanie Ott (@theottlab.bsky.social)
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Reposted by The Ott Lab
amfAR @amfarofficial.bsky.social · 05/03/2025
HIV research has led to breakthroughs in antiviral treatments & cancer therapies. amfAR’s Dr. Andrea Gramatica & Dr. Melanie Ott (@theottlab.bsky.social) discuss how investing in one virus drives medical innovation. www.amfar.org/news/shaping...
amfar.org
Shaping the Future of HIV
amfAR interviewed Gladstone Institutes’ Dr. Melanie Ott about her work on HIV, hepatitis C, and other viruses, and the promise of new technologies.
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The Ott Lab @theottlab.bsky.social · 04/03/2025
Please join us at our mini-symposium on the latest advancements in HIV persistence next week. gladstone.org/events/hiv-p... via @gladstoneinst.bsky.social
gladstone.org
HIV Persistence: Where We Are Now and Where We Need to Go
Mini-symposium series on the latest advancements in HIV persistence.
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The Ott Lab @theottlab.bsky.social · 01/03/2025
Yesterday we hosted the German Consulate and the German Research Foundation for their Global Innovation Summit at @gladstoneinst.bsky.social Thank you to everyone involved! Photos by © Barak Shrama
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The Ott Lab @theottlab.bsky.social · 21/02/2025
Melanie Ott talks to Newsweek about the risk of bird flu from drinking milk. Check it out! www.newsweek.com/can-you-get-...
newsweek.com
Can you get bird flu from drinking milk? What to know as cows are infected
Consumers can safely drink pasteurized milk, despite reports of dairy cattle infected with the new strain of bird flu.
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Reposted by The Ott Lab
The Buck Institute for Research on Aging @buckinstitute.org · 13/02/2025
Our CEO, Eric Verdin answered questions about the administration’s proposed budget cuts to the NIH at a hearing before the Senate Special Committee on Aging this afternoon. Hear his exchange with Angela Alsobrook D-MD here: youtu.be/XrhHldez1AI
youtu.be
Eric Verdin, MD, President of the Buck Institute in hearing of the Senate Special Committee on Aging
YouTube video by Buck Institute for Research on Aging
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Reposted by The Ott Lab
Gladstone Institutes @gladstoneinst.bsky.social · 16/02/2025
Gladstone virologist Melanie Ott talks to Salon about the #BirdFlu. Read more to learn how you can best understand and manage your risk.
buff.ly
Your questions about bird flu answered by experts
H5N1 isn’t going away anytime soon and could become a pandemic. Here are some tips to help you understand your risk
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Stephan Hacker @stephanhacker2.bsky.social · 22/01/2025
Interesting bioRxiv preprint by a team around Charles Craik, Adam Renslo and @theottlab.bsky.social. Inhibitors for Mpro of coronaviruses based on a dihydrouracil chemotype and a propargyl amide warhead as reactive group to engage the catalytic cysteine. #chemsky #ChemBio www.biorxiv.org/cont...
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Reposted by The Ott Lab
Taha Y. Taha @taha801.bsky.social · 03/01/2025
Thrilled to share our latest work identifying that #SARSCoV2 #Omicron variants harboring an L260F mutation in NSP6 have enhanced replication and pathogenesis. A not so brief thread 🧵
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