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Timothy Földes

@timothyfoldes.bsky.social

55 followers 115 following 0 posts

Postdoc @ MirnyLab studying genome folding & enhancer-promoter communication.

Posts Replies Media

Reposted by Timothy Földes

Anders Sejr Hansen @andersshansen.bsky.social · 22/06/2026

(1/n) Very excited to share tri-lab collab (Mirny & Zechner) led by Harvey, Henrik & Jack: Q: How do enhancers & promoters interact in space (contact vs. action-at-a-distance) and time (stable vs. transient)? A: Transient E-P contact (~25-42 nm lasting ~10-20 sec): www.biorxiv.org/content/10.6...

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Reposted by Timothy Földes

Nezar Abdennur @nvictus.bsky.social · 18/05/2026

Many of you may have received pessimism from me over the years about using Hi-C to predict distal regulatory effects, mired with paradoxical optimism that cohesin loop extrusion is key. Well, the theoretical story underlying my seemingly paradoxical rambling is finally ready to be told. 👇

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Reposted by Timothy Földes

Elphege Nora Lab at UCSF @elphegenoralab.bsky.social · 13/05/2026

Why can't we explain enhancer action despite 2 decades of chromosome conformation technologies? 😬 Our new study spearheaded by Leonid Mirny's group points to a flaw in our assumptions, and to a solution from physical principles By @timothyfoldes.bsky.social 💻& @karissalhansen.bsky.social 🧪 🧵👇

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Reposted by Timothy Földes

Elias Friman @eliasfriman.bsky.social · 11/05/2026

Is distal gene activation by enhancers inherently different from promoter-proximal activation? We propose not. But both cohesin and cooperativity are important aspects of how transcription is affected. Happy to share our recent preprint (thread below) 1/ www.biorxiv.org/content/10.6...

biorxiv.org

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