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Pascal Notin

@pascalnotin.bsky.social

578 followers 75 following 13 posts

Research in AI for Protein Design @Harvard | Prev. CS PhD @UniofOxford, Maths & Physics @Polytechnique

Posts Replies Media

Reposted by Pascal Notin

Kevin K. Yang 楊凱筌 @kevinkaichuang.bsky.social · 20/08/2026

Binder design is nice and all, but here we have three agents sharing data and autonomously controlling a lab to design enzymes with shifted substrate scopes and high activity! @cobanbrooks.bsky.social @pascalnotin.bsky.social @philromero.bsky.social www.biorxiv.org/content/10.6...

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Reposted by Pascal Notin

jproney @jproney.bsky.social · 13/03/2026

I'm excited to announce some major updates to our ProteinEBM paper with Chenxi Ou @sokrypton.org!

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Pascal Notin @pascalnotin.bsky.social · 18/06/2025

🚨 New paper 🚨 RNA modeling just got its own Gym! 🏋️ Introducing RNAGym, large-scale benchmarks for RNA fitness and structure prediction. 🧵 1/9

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Reposted by Pascal Notin

Kevin K. Yang 楊凱筌 @kevinkaichuang.bsky.social · 11/06/2025

End-to-end differentiable homology search for protein fitness prediction. @yaringal.bsky.social @deboramarks.bsky.social @pascalnotin.bsky.social arxiv.org/abs/2506.089...

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Reposted by Pascal Notin

Isabelle Zane @isabellease.bsky.social · 21/05/2025

Pascal Notin at #VariantEffect25

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Pascal Notin @pascalnotin.bsky.social · 08/05/2025

Have we hit a "scaling wall" for protein language models? 🤔 Our latest ProteinGym v1.3 release suggests that for zero-shot fitness prediction, simply making pLMs bigger isn't better beyond 1-4B parameters. The winning strategy? Combining MSAs & structure in multimodal models!

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Reposted by Pascal Notin

bioRxiv Biophysics @biorxiv-biophys.bsky.social · 25/03/2025

Large-scale discovery, analysis, and design of protein energy landscapes www.biorxiv.org/content/10.1101/202…

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