Nature Biomedical Engineering, Published online: 28 September 2026; doi:10.1038/s41551-026-01815-3Author Correction: Intermittent hypobaric pressure induces selective senescent cell death and alleviates age-related osteoporosis

Nature Biomedical Engineering, Published online: 23 September 2026; doi:10.1038/s41551-026-01791-8Unsaturated phospholipids unexpectedly form multilamellar, multivesicular liposomes that efficiently encapsulate hydrophilic drugs and suppress burst release. These structures enable ultra-slow drug release and produce weeks-long sciatic nerve block with tetrodotoxin in rats.

Nature Biomedical Engineering, Published online: 23 September 2026; doi:10.1038/s41551-026-01793-6Contrary to expectations that unsaturation accelerates release, unsaturated phospholipid liposomes showed 3-fold higher loading and markedly reduced initial and sustained release due to multilamellar–multivesicular structure.

Nature Biomedical Engineering, Published online: 22 September 2026; doi:10.1038/s41551-026-01796-3A microfluidic method restructures preformed lipid nanoparticles by inserting a metabolic-enhancing RNA into an internal peripheral compartment while relocating the therapeutic RNA towards the core, thereby improving vaccine therapeutic outcomes.

Nature Biomedical Engineering, Published online: 22 September 2026; doi:10.1038/s41551-026-01773-wBiomimetic, non-genetic, light-responsive hollow-sphere graphitic carbon nitride nanoparticles can modulate biological activity from subcellular and cellular levels to whole-tissue function and enable therapeutic biomodulation in the retinas of visually impaired mice.

Nature Biomedical Engineering, Published online: 21 September 2026; doi:10.1038/s41551-026-01802-8A nanomedicine comprising a guide RNA and an mRNA co-encapsulated in a lipid nanoparticle for delivery to hepatocytes holds promise for a functional cure for chronic hepatitis B through epigenetic silencing.

Nature Biomedical Engineering, Published online: 16 September 2026; doi:10.1038/s41551-026-01808-2The source data underlying results and figures in our manuscripts can be critical for assessing the rigour of our studies and for reproducibility. Ensuring the quality and provenance of these data during manuscript preparation is essential bookkeeping.

Nature Biomedical Engineering, Published online: 16 September 2026; doi:10.1038/s41551-026-01807-3As medical devices evolve faster than the rules governing them, regulatory bodies can struggle to keep up. A suite of Comments in this issue seek to inform future policy in this space.

Nature Biomedical Engineering, Published online: 16 September 2026; doi:10.1038/s41551-026-01797-2A 6-gene-edited porcine liver is orthotopically transplanted into a brain-deceased individual and maintains functional activity for 11 days.

Nature Biomedical Engineering, Published online: 11 September 2026; doi:10.1038/s41551-026-01789-2Advances in three-dimensional endometrial in vitro models are providing physiologically relevant systems to investigate embryo implantation, tissue remodelling and reproductive disorders, expanding our toolbox for supporting women’s health.

Nature Biomedical Engineering, Published online: 11 September 2026; doi:10.1038/s41551-026-01787-4Applying extensive chemical modifications to RNA motifs substantially enhances prime editing efficiency in vivo and can be applied for improved efficiencies across RNA-based editing systems.

Nature Biomedical Engineering, Published online: 10 September 2026; doi:10.1038/s41551-026-01810-8Author Correction: Radiotherapy-triggered reduction of platinum-based chemotherapeutic prodrugs in tumours

Nature Biomedical Engineering, Published online: 09 September 2026; doi:10.1038/s41551-026-01792-7Generative artificial intelligence (AI) has revolutionized protein engineering and has enabled de novo design of protein binders against dozens of target antigens. Our study combines AI-assisted binder design, binder integration into chimaeric antigen receptor (CAR) constructs and scalable in vitro and in vivo cell models to infer amino acid sequences and protein structures of designed binders that might facilitate efficacious CAR T cell therapies.

Nature Biomedical Engineering, Published online: 09 September 2026; doi:10.1038/s41551-026-01790-9A generative protein design workflow addresses important challenges with de novo protein engineering of chimaeric antigen receptors (CARs) to improve targeting of proteins important in cancer and create more effective CAR T therapies.

Nature Biomedical Engineering, Published online: 07 September 2026; doi:10.1038/s41551-026-01794-5Author Correction: A base editor for the long-term restoration of auditory function in mice with recessive profound deafness

This Review highlights recent technological advances in measuring dietary food intake, including artificial intelligence-based methods and approaches informed by the gut microbiome.

Reference materials should be adopted as a common calibrator for multiomics measurement and co‑profiled with study samples. Multiomics results should be reported as sample‑to‑reference ratios so that ...

Nature Biomedical Engineering, Published online: 31 August 2026; doi:10.1038/s41551-026-01782-9A protein engineering strategy enables nitric oxide-triggered reactivation of proteins using genetically encoded caged amino acids, allowing inflammation-localized control of protein activity, viral gene delivery and biosensing in vivo.

Nature Biomedical Engineering, Published online: 31 August 2026; doi:10.1038/s41551-026-01779-4This large-scale study of white matter structural connectivity during development reveals biomarkers associated with attention deficit hyperactivity disorder in youth that track symptom trajectories and predict differential treatment response.

Nature Biomedical Engineering, Published online: 28 August 2026; doi:10.1038/s41551-026-01785-6This Perspective argues that biological discovery and drug development should be linked in a continuous data feedback loop that iteratively refines therapeutic hypotheses, drug design and patient stratification across discovery and clinical stages.

Nature Biomedical Engineering, Published online: 26 August 2026; doi:10.1038/s41551-026-01766-9We present a multiple-instance learning framework that aggregates patch-level features into reliable slide-level predictions through the use of random sampling at both patch and feature levels. Our approach enables large-batch optimization and consistent performance gains across 35 clinical tasks and 4 foundation models, and supports principled uncertainty estimation for every slide-level prediction.

Nature Biomedical Engineering, Published online: 26 August 2026; doi:10.1038/s41551-026-01774-9Autophagy receptors are engineered fusing LC3 to cytoplasm-stable antibody variants and are delivered via small extracellular vesicles or adeno-associated virus to eliminate pathological Tau and TDP-43 in animal disease models.

Nature Biomedical Engineering, Published online: 25 August 2026; doi:10.1038/s41551-026-01781-wBridging consumer technology and medicine, the authors of this Comment propose ANTLiON, a regulatory sandbox designed to govern the clinical integration of consumer-generated health data as sentinel data.

Nature Biomedical Engineering, Published online: 25 August 2026; doi:10.1038/s41551-026-01767-8nnMIL is a broadly applicable multiple-instance learning framework connecting patch-level foundation models to robust slide-level clinical predictions that outperforms established methods across tasks for reliable digital pathology.

Nature Biomedical Engineering, Published online: 25 August 2026; doi:10.1038/s41551-026-01757-wA multiresponsive hydrogel delivering small interfering RNA to silence TrkB in residual tumour cells after surgery disrupted malignant tumour–neuron synaptic interactions, suppressed glioblastoma regrowth and increased median survival.

Nature Biomedical Engineering, Published online: 24 August 2026; doi:10.1038/s41551-026-01772-xMobilio is a smartphone application that combines smartphone camera-based imaging and real-time processing algorithms with personalized audio feedback to assist blind people and those with visual impairment with navigating outdoor environments.

Nature Biomedical Engineering, Published online: 24 August 2026; doi:10.1038/s41551-026-01754-zHisToSpatialCNV is a deep-learning framework that infers spatial copy number variation patterns from H&E images, enabling tumour subclone identification, phylogenetic reconstruction and observation of pathway alterations linked to tumour progression.

Nature Biomedical Engineering, Published online: 21 August 2026; doi:10.1038/s41551-026-01770-zAntibody-modified targeted lipid nanoparticles enable precise, durable genetic modification of human haematopoietic stem cells directly in the bone marrow.

Nature Biomedical Engineering, Published online: 20 August 2026; doi:10.1038/s41551-026-01768-7This Review introduces the current classes of intracellular binders and their emerging applications in biosensing, imaging and protein control. It also discusses the promise and challenges of translational adoption of these tools.

Nature Biomedical Engineering, Published online: 20 August 2026; doi:10.1038/s41551-026-01776-7CRISPRLungo is a computational pipeline for characterizing complex DNA sequence changes induced by genome editing made available through a user-friendly web application.

Nature Biomedical Engineering, Published online: 17 August 2026; doi:10.1038/s41551-026-01764-xConceptCLIP is an explainable foundation model that leverages MedConcept-23M, a large-scale dataset comprising 23 million biomedical image–text–concept triplets, for precise and interpretable medical image analysis and diagnostics.

Nature Biomedical Engineering, Published online: 17 August 2026; doi:10.1038/s41551-026-01771-yA magnetic soft robot with cilia-like actuation enhances local blood flow to restore transport and improve the delivery of therapeutics in occluded vessels, accelerating clot dissolution and reducing recanalization time.

Nature Biomedical Engineering, Published online: 14 August 2026; doi:10.1038/s41551-026-01778-5The potential for machine learning to reshape the medical landscape is vast, and we are in the midst of an explosion in tool development. In this Focus issue, we share both critical and forward-looking insights from experts on artificial intelligence in medicine and emphasize how thoughtful engineering is poised to make the types of tools needed for long-term clinical impact.

Nature Biomedical Engineering, Published online: 14 August 2026; doi:10.1038/s41551-026-01775-8A cell encapsulation strategy inspired by the biological development of the zona pellucida enables the spontaneous formation of thin capsules on cell surfaces. Encapsulated islets were successfully used to achieve normoglycaemia in diabetic mice.

Nature Biomedical Engineering, Published online: 13 August 2026; doi:10.1038/s41551-026-01749-wKey tissue features shared by fibrotic diseases are distilled into clear design rules for human in vitro models, with practical guidance on choosing cells, matrices and platforms for mechanistic studies and drug testing.

Nature Biomedical Engineering, Published online: 12 August 2026; doi:10.1038/s41598-026-62801-yModel-free multiparametric analysis of SHG images reveals collagen signatures in breast cancer

Nature Biomedical Engineering, Published online: 12 August 2026; doi:10.1038/s41598-026-66901-7Development of samarium-153 oxide loaded polystyrene radiotracer particles for gamma scintigraphy of whole gastrointestinal transit study

Nature Biomedical Engineering, Published online: 12 August 2026; doi:10.1038/s41598-026-64954-2AlzheiNN: a convolutional neural network-based model for Alzheimer’s disease classification

Nature Biomedical Engineering, Published online: 12 August 2026; doi:10.1057/s41599-026-08691-xService trade liberalization and manufacturing value chain upgrading: a quasi-natural experiment from China

Nature Biomedical Engineering, Published online: 12 August 2026; doi:10.1038/s41598-026-66659-yExperiences of kinesiophobia in patients with chronic obstructive pulmonary disease: a qualitative phenomenological study

Nature Biomedical Engineering, Published online: 12 August 2026; doi:10.1038/s41598-026-66068-1Multi-level violence recognition via hybrid convolutional-attention and recurrent architectures

Nature Biomedical Engineering, Published online: 12 August 2026; doi:10.1038/s41598-026-63846-9Correction: A five-dimensional classical framework for gravitational and quantum phenomena

Nature Biomedical Engineering, Published online: 12 August 2026; doi:10.1038/s41551-026-01760-1TRICARE is a deep-learning triage framework that serves to enhance the benefits of volumetric imaging for improved diagnostics without increasing pathologist workloads by identifying high-risk two-dimensional cross sections in three-dimensional pathology datasets.

Nature Biomedical Engineering, Published online: 11 August 2026; doi:10.1038/s41551-026-01762-zThis Perspective assesses the role of foundation models as clinical tools and introduces real-world evaluation and assessment of foundation models (REAL-FM), a framework for assessing data, technical readiness and clinical value towards responsible artificial intelligence.

Nature Biomedical Engineering, Published online: 10 August 2026; doi:10.1038/s41551-026-01783-8Author Correction: The evolving role of cytokines for CAR-T cell manufacturing and beyond

Nature Biomedical Engineering, Published online: 07 August 2026; doi:10.1038/s41551-026-01742-3This Perspective explores and outlines how causal graph neural networks can impact the future of artificial intelligence in healthcare, from diagnostics to causal digital twins.

Nature Biomedical Engineering, Published online: 05 August 2026; doi:10.1038/s41551-026-01765-wEngineered lipid nanoparticles enable CD34-targeted delivery and in vivo editing of haematopoietic stem and progenitor cells while preserving haematopoiesis.

Nature Biomedical Engineering, Published online: 04 August 2026; doi:10.1038/s41551-026-01769-6XunZi is an AI biologist capable of synergizing logical reasoning and multimodal data fusion to generate de novo therapeutic target hypotheses. XunZi was used to discover two therapeutic targets in Parkinson’s disease that were subsequently verified.

Nature Biomedical Engineering, Published online: 31 July 2026; doi:10.1038/s41551-026-01750-3Legislative change must fix the European Union’s disharmonized map of early-stage medical device clinical study requirements, whereby fragmented interpretations across Member States create barriers to innovation and delay patient access to life-saving technologies.

Nature Biomedical Engineering, Published online: 30 July 2026; doi:10.1038/s41551-026-01702-xA structurally engineered sulfated polysaccharide rebalances bone homeostasis by limiting bone resorption without depleting regenerative cell populations.