iiinova — where your digital self keeps evolving

Reposted by Julia Lazzari-Dean

Alfred Millett-Sikking @amsikking.bsky.social · 20/07/2026

Ultrafast 3D imaging just got faster! Introducing: "Instant dual-view Snouty (iDV-Snouty) light-sheet microscopy" -> Double the data rate of a Snouty microscope by adding a 2nd view! Use the extra view for a variety of imaging modes! Article here: amsikking.github.io/idv-snouty_l...

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Reposted by Julia Lazzari-Dean

Andrew G. York @andrewgyork.bsky.social · 29/04/2026

Meet MagLuc: a magnetically-controlled luminescent protein. This is a foundational tool for remote control of biological processes, also known as "magnetogenetics". Can you tell when the magnetic field turns on and off? From @mariaingaramo.bsky.social and the team at @nonfictionlabs.bsky.social

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Julia Lazzari-Dean @jlazzaridean.bsky.social · 12/05/2026

We invented “triplet tumbling microscopy” (TTM) to track protein-protein interactions in living cells! Tag your protein with GFP and see it interact with *untagged* binding partners www.biorxiv.org/content/10.6...

A cartoon overview of triplet tumbling microscopy, comparing data from bound and unbound samples.

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Julia Lazzari-Dean @jlazzaridean.bsky.social · 05/05/2026

We’re hiring a scientist to work on microscopy at Calico! If you’re excited about developing and applying cutting edge microscopy to a variety of biological questions, we’d love to hear from you. Find more information and apply here: www.calicolabs.com/careers/?gh_...

calicolabs.com

Careers - Calico

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Julia Lazzari-Dean @jlazzaridean.bsky.social · 09/03/2026

Hi microscopy folks! I'm looking for your advice 💡 We're shopping for cyclic immunofluorescence instruments to increase throughput and multiplex-ability of tissue IF. Have you worked with cyclic IF platforms (Comet, CellScape, Cell DIVE)? Thoughts? Pain points? Alternatives to consider? Thanks!

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Julia Lazzari-Dean @jlazzaridean.bsky.social · 05/01/2026

I've spent many afternoons crouched over a microscope with a pipette, waiting for the exact right moment to add my perturbation (& not breathing so I don't bump anything). Now I can just program it in and have a more relaxing experiment :)

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Julia Lazzari-Dean @jlazzaridean.bsky.social · 18/12/2025

I'm excited to be hiring an intern to develop new fluorescence-based assays for alpha synuclein aggregation at Calico during summer 2026 😃 🔬 If you're a current PhD student who loves microscopy, unnatural amino acids, and/or synuclein biophysics, please apply! www.calicolabs.com/careers/?gh_...

calicolabs.com

Careers - Calico

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Julia Lazzari-Dean @jlazzaridean.bsky.social · 05/12/2023

Want to measure protein-protein interactions? We recently did some dreaming about how you can do this with a single fluorescent tag using molecular "tumbling." We simulated how you'd do this on a lightsheet, a flow cytometer, or a cheap handheld device. We even took prelim data on a commercial rig:

Data from an unmodified commercial confocal instrument that we jerry-rigged into taking tumbling measurements. A proof of principle & far from what you could do with a custom rig!

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Reposted by Julia Lazzari-Dean

DrLachie @drlachie.bsky.social · 30/10/2023

I no longer have the follower count nor the algorithm to help promote stuff, but @jlazzaridean.bsky.social and Andy York reached out to me a while ago to do an animation explaining a way to measure moluecular "tumbling" and I think it worked out pretty well! andrewgyork.github.io/tumbling_is_...

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Julia Lazzari-Dean @jlazzaridean.bsky.social · 24/10/2023

Hi bluesky! Excited to share some new work in voltage sensing I was a part of in my past life in the Evan Miller lab at Berkeley: a versatile dye for both fast voltage imaging and lifetime-based quantification Introducing CRhOMe: www.biorxiv.org/content/10.1...

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