Nasal tissue harbours T cells that ‘remember’ a pathogen long after infection is past.

Here, the authors discuss principles of experimental design that are relevant for all biology research, along with special considerations for projects using -omics approaches, highlighting common expe...

npj Viruses - Virion motility of sialoglycan-cleaving respiratory viruses

Darwinian evolution of immunoglobulin genes within germinal centers (GC) underlies the progressive increase in antibody affinity following antigen exposure. Whereas the mechanics of how competition be...

Immune responses lie at the heart of almost every aspect of human health, including host responses to infection, autoimmunity, cancer, metabolism and aging. While adaptive immune responses by B and T…

npj Viruses - Kinetic MUNANA assay reveals functionally relevant antibody epitopes on Influenza A virus neuraminidase

In this article for the Highlights of 2024 series, we review the latest advances in the biology of the germinal center response. These discoveries provide key insights into germinal center function a...

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Immune responses lie at the heart of almost every aspect of human health, including host responses to infection, autoimmunity, cancer, metabolism and aging. While adaptive immune responses by B and T…

The nasal mucosa is the first immunologically active site that respiratory viruses encounter and establishing immunity at the initial point of path...

The nasal mucosa is the first immunologically active site that respiratory viruses encounter and establishing immunity at the initial point of path...

Effective control of viral infection requires rapid induction of the innate immune response, especially the type I and type III interferon (IFN) systems. Despite the critical role of IFN induction in ...

H5N1 strain-specific antibodies are higher in older individuals and correlate more with birth year than with age, suggesting that younger individuals are potentially more likely to benefit from H5N1 v...

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Profiling of the location and transcriptome of tissue-resident memory CD8 T cell formation at single-transcript resolution finds regionalized signalling as the basis of immune diversity in t...

H7N9 influenza A virus circulates in poultry but can also infect humans with often fatal outcome. Here, Chen et al. identify a novel nanobody that cross-reacts between H7N9 and human viruses H1N1 and ...

Nature Communications - H7N9 influenza A virus circulates in poultry but can also infect humans with often fatal outcome. Here, Chen et al. identify a novel nanobody that cross-reacts between H7N9...

Vaccination with different group 2 influenza subtypes alters the balance of the human B cell response toward two supersites on the influenza stem.

Author summary Successful replication and transmission of influenza A viruses (IAVs) requires effective subversion of the innate immune response. We developed a new single cell method to examine the i...

Ataca et al. describe a pathway to generate cross-reactive B cells against influenza hemagglutinin by engaging a subdominant immunoglobulin germline-encoded motif through prime-boost vaccination in IG...

Our understanding of T-cell-dependent humoral responses has been largely shaped by studies involving model antigens such as recombinant proteins and viruses [1][1],[2][2]. In these contexts, B cells i...

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The gut commensal protist Tritrichomonas musculis (T.mu) boosts T cell–dependent IgA. T.mu-driven IgA modifies the commensal bacterial microbiota and impro