Transposable elements mobilize within and occasionally between genomes, including from host to virus. We identified two insertions of the human BC200 noncoding RNA gene in the poxvirus molluscum conta...

Retrotransposons can infect neighboring cells using a mechanism that relies on a small fusogen-like protein rather than on the envelope protein that is typically required for infection.

Human infection with or vaccination against influenza A virus has been one of the most informative systems for understanding how human antibody repertoires recognize viral glycoproteins. Decades of a...

As Dr. Anthony Fauci has faced public scrutiny from congressional Republicans, the D.O.J. has pursued a quieter and more expansive effort against a wider circle of researchers.

Under a new partnership, the Defense Department would play a larger role in biodefense and pandemic preparedness. Democrats warned it could allow a Pentagon cash grab.

An epidemic’s expected course is determined by the magnitude and timing of a typical person’s infectiousness — captured, in turn, by the basic reproduction number and the generation-time distribution....

Tracking influenza virus populations over 72 passages, the authors show that hundreds of defective viral genomes compete for dominance, ultimately resolving into a single variant carrying an adaptive ...

Thayer et al. used multiple approaches to uncover why only a few cells in a population express IFN upon RNA stimulation. They found that variation in cell signaling state at the time of stimulation is...

The U.S. National Science Foundation (NSF) is announcing plans to renew and revise its collection for its financial assistance policies and procedures. In accordance with the requirements of the Paper...

Most pathogens have proteins on their surface which are recognised by our immune system and prime it to make antibodies that protect us from future infection. Vaccines contain these proteins to activa...

The development of deep mutational scanning (DMS) approaches has led to a fundamental shift in our ability to connect viral genotype and phenotype (1) and accelerated our understanding of viral evolut...

Antibody affinity maturation results from a somatic evolutionary process that takes place in the germinal center. A “parallel replay” experiment on germinal center B cells reveals the evolutionary for...

The existence of viruses as obligate intracellular parasites with high mutation rates sets them apart from other forms of life in fundamental ways. Frequent errors in replication and assembly processe...

What OMB’s Proposed Federal Financial Assistance Rule Means in Practice

While SARS-CoV-2 and influenza continue to place a significant burden on population health, within-household differences in decisions towards vaccination and seeking care across these two pathogens, a...

Russell Vought is going destroy American Science

Giant endogenous viral elements integrated into the multicellular alga Ectocarpus are reactivated by specific temperature cues, driving productive latent viral infections.

Eight of the top ten officials at the US National Institute of Allergy and Infectious Diseases have now been pushed out since President Donald Trump took office.

HHS memo says Ralph Baric had a “pattern of deception” in describing virus studies long before pandemic

Work at an Indiana University biology lab was halted amid federal scrutiny, affecting dozens of researchers. “The damage is significant and mounting,” the department chair told The Chronicle.

HHS memo says Ralph Baric had a “pattern of deception” in describing virus studies long before pandemic

Copy-back viral genomes (cbVGs) are generated during infection when the polymerase drops off from the template and reattaches to the nascent strand, and they are major drivers of antiviral immunity. H...