Sign in

C.A.M(Xander)_de_Haan.bsky.social

@xdh.bsky.social
104 followers 182 following 20 posts

Molecular Virology, IAV, PMV, CoV, RSV, EEHV, Associate professor at Utrecht University.

PostsRepliesMedia
C.A.M(Xander)_de_Haan.bsky.social @xdh.bsky.social · 30/09/2026
Great work by Katherine, colleagues and collaborators!
000
Reposted by C.A.M(Xander)_de_Haan.bsky.social
Utrecht Virology Lab @utrechtvirology.bsky.social · 02/07/2026
📢 We're hiring! We are looking for an Assistant or Associate Professor to join our team at Utrecht University. If you're excited about leading an independent research programme in a collaborative #virology community, we'd love to hear from you. Please share! 👇🦠 #AcademicJobs #FacultyPosition
11110
C.A.M(Xander)_de_Haan.bsky.social @xdh.bsky.social · 02/07/2026
www.uu.nl/en/organisat...
uu.nl
Assistant or Associate Professor in Virology
000
Reposted by C.A.M(Xander)_de_Haan.bsky.social
Jessica Pickett @pickettjessica.bsky.social · 16/03/2026
Ok folks: have at it
jamespickett.info
Working Paper — New Historical Evidence on the 'Russian Influenza' of 1889
James Pickett and Jessica Pickett — circulated for comment. Primary source documentation from the Bukharan Archive on the 1889 pandemic.
1145
Reposted by C.A.M(Xander)_de_Haan.bsky.social
Utrecht Virology Lab @utrechtvirology.bsky.social · 27/04/2026
Check out the latest #virology research from @xdh.bsky.social! Human respiroviruses prefer α2-3 sialic acid, yet infect the α2-6-rich upper airway. We show they solve this via heteromultivalent binding: using α2-6Sia as auxiliary anchors when α2-3Sia is scarce. 🦠🍬 www.pnas.org/doi/10.1073/...
pnas.org
Paramyxovirus infection driven by heteromultivalent sialoglycotope binding | PNAS
Sialic acids (Sia) on glycoproteins and glycosphingolipids act as receptors for many respiratory viruses, including human influenza A viruses and r...
0167
C.A.M(Xander)_de_Haan.bsky.social @xdh.bsky.social · 04/12/2025
Important work that supports the ongoing vaccination trial throughput Europe by the EEHV research group @utrechtvirology.bsky.social @utrechtuniversity.bsky.social #EEHV
052
Reposted by C.A.M(Xander)_de_Haan.bsky.social
Thelonevirologist @thelonevirologist.bsky.social · 30/07/2025
Merbecovirus S2 subunit vaccines elicit cross reactive antibodies and provide partial protection against MERS coronavirus www.nature.com/articles/s44...
nature.com
Merbecovirus S2 subunit vaccines elicit cross reactive antibodies and provide partial protection against MERS coronavirus - npj Viruses
npj Viruses - Merbecovirus S2 subunit vaccines elicit cross reactive antibodies and provide partial protection against MERS coronavirus
022
Reposted by C.A.M(Xander)_de_Haan.bsky.social
Nonia Pariente @npariente.bsky.social · 30/07/2025
Respiratory infections reactivate dormant metastatic breast cancer cells in mouse lungs, correlating with evidence in humans that #SARS-CoV-2 infection increases the risk of cancer-related mortality & lung metastasis 😎 biology but double whammy for cancer patients www.nature.com/articles/s41... 🧪
nature.com
Respiratory viral infections awaken metastatic breast cancer cells in lungs - Nature
Mouse models show that respiratory infections from viruses such as influenza and SARS-CoV-2 can trigger metastasis of dormant breast cancer cells in the lungs, a finding supported by epidemiological d...
97245
Reposted by C.A.M(Xander)_de_Haan.bsky.social
Katie Downes @dr-downes.bsky.social · 30/07/2025
Very excited to announce that my first, first author paper, is now on BioRxiv! In this paper we unambiguously show #COPII coated vesicles in unperturbed human cells for the very first time!! Make my day and check it out! www.biorxiv.org/content/10.1... #Cryo-ET #TeamTomo #Cryo-CLEM ❄️🔬❄️🔬❄️🔬❄️🔬
610031
C.A.M(Xander)_de_Haan.bsky.social @xdh.bsky.social · 29/07/2025
New review paper from the influenza group @utrechtvirology.bsky.social together with Mengying Liu and Erik de Vries on virion motility of sialoglycan-cleaving respiratory viruses through mucus and on the surface cells in NPJ viruses @natureportfolio.nature.com doi.org/10.1038/s442...
doi.org
Virion motility of sialoglycan-cleaving respiratory viruses - npj Viruses
npj Viruses - Virion motility of sialoglycan-cleaving respiratory viruses
0127
Reposted by C.A.M(Xander)_de_Haan.bsky.social
Joost Snijder @joostsnijder.bsky.social · 22/07/2025
We sequenced the anti-RSV-F antibody 131-2a by mass spec and determined its epitope by cryoEM. New insights in postfusion specific binding and antigenic site I. Now published in ACS Infectious Diseases @pubs.acs.org. pubs.acs.org/doi/10.1021/... @xdh.bsky.social @hangryhobbit.bsky.social
2339
C.A.M(Xander)_de_Haan.bsky.social @xdh.bsky.social · 21/07/2025
Full article: Identification of β4GALNT2 as an anti-hPIV3 factor through genome-wide CRISPR/Cas9 library screening. Nice work by former PhD student Xuesheng Wu. Many thanks to our collaborators!
000
Reposted by C.A.M(Xander)_de_Haan.bsky.social
Chlanda lab @chlandalab.bsky.social · 11/06/2025
We are happy this work by Sarah Peterl et al. is out in EMBO J! It was an exciting collaborative effort of several groups in the SFB1129 consortium on pathogen replication and spread. Check out the correlated light and scanning EM method to study virus morphology changes during spread!
0104
C.A.M(Xander)_de_Haan.bsky.social @xdh.bsky.social · 11/06/2025
www.cell.com/iscience/ful... Great work by Mengying Liu and others!
cell.com
Cell-based sialoglycan arrays for directly comparing influenza A virus receptor requirements for binding and infection
Biological sciences; Microbiology; Natural sciences; Virology
000
Reposted by C.A.M(Xander)_de_Haan.bsky.social
Ed Hutchinson @socialinfluenza.bsky.social · 04/06/2025
There's still time to submit your molecular biology abstracts to this year's #ESWI2025 meeting on #Influenza, #RSV and #SARSCoV2. The ESWI meetings are a brilliant way to see your work in context, as they consider these respiratory viruses all the way from molecular biology to policy...
264
Reposted by C.A.M(Xander)_de_Haan.bsky.social
KyleIridian 🇺🇦 🌻 @kyleiridian.bsky.social · 15/05/2025
Eurosurveillanc : Human infections with Eurasian avian-like swine influenza virus detected by coincidence via routine respiratory surveillance systems, the Netherlands, 2020 to 2023 Dirk Eggink et al www.eurosurveillance.org/content/10.2...
022
Reposted by C.A.M(Xander)_de_Haan.bsky.social
Yi-Wei Chang @yiweichang.bsky.social · 15/05/2025
Excited to share our new @science.org paper! Led by postdocs Ruchao Peng and Xin Xu, we used cryo-EM/ET to reveal the influenza ribonucleoprotein complex structure and its strand-sliding mechanism for RNA synthesis, paving the way for new antivirals. www.science.org/doi/10.1126/...
science.org
Molecular basis of influenza ribonucleoprotein complex assembly and processive RNA synthesis
Influenza viruses replicate and transcribe their genome in the context of a conserved ribonucleoprotein (RNP) complex. By integrating cryo–electron microscopy single-particle analysis and cryo–electro...
712356
Reposted by C.A.M(Xander)_de_Haan.bsky.social
Dimitri Drekonja, MD, MS @dimitridrekonja.bsky.social · 12/05/2025
Also - we eradicated rinderpest in 2010 (joining smallpox as only diseases eradicated). Turns out fewer anti-vaxxers among cattle 🤦🏻‍♂️
02712
Reposted by C.A.M(Xander)_de_Haan.bsky.social
Thelonevirologist @thelonevirologist.bsky.social · 13/05/2025
Binding antibody titers against the hemagglutinin and neuraminidase correlate with protection against medically attended influenza A and B disease journals.asm.org/doi/10.1128/...
journals.asm.org
Binding antibody titers against the hemagglutinin and neuraminidase correlate with protection against medically attended influenza A and B disease | Journal of Virology
There is a great need to better understand correlates of protection (CoP) against influenza A and B viruses (IAV/IBV). In our study, we analyzed paired plasma and nasal swabs from patients presenting ...
031
Reposted by C.A.M(Xander)_de_Haan.bsky.social
Thelonevirologist @thelonevirologist.bsky.social · 13/05/2025
Saudi Arabia confirms 9 MERS cases, including hospital cluster www.cidrap.umn.edu/mers-cov/sau...
cidrap.umn.edu
Saudi Arabia confirms 9 MERS cases, including hospital cluster
0106
C.A.M(Xander)_de_Haan.bsky.social @xdh.bsky.social · 24/04/2025
Next week I will move to the lab of Adolfo Garcia-Sastre at Mount Sinai for a three month sabbatical. Looking forward to meeting many old and new colleagues and friends and to visiting NYC itself!
000
Reposted by C.A.M(Xander)_de_Haan.bsky.social
Joost Snijder @joostsnijder.bsky.social · 21/03/2025
Time for the Dutch Annual Virology Symposium, in the beautiful Geertekerk in Utrecht. Stoked to present our work on antibody sequencing 😁
0152
Reposted by C.A.M(Xander)_de_Haan.bsky.social
CIDRAP @cidrap.bsky.social · 13/02/2025
Uganda’s Ebola Sudan outbreak appears stable No transmission has been found outside of a single chain, and eight patients in treatment are stable. www.cidrap.umn.edu/e... Photo: NIAID/Flickr cc
1289
Reposted by C.A.M(Xander)_de_Haan.bsky.social
Ed Hutchinson @socialinfluenza.bsky.social · 04/02/2025
Do you like doing experiments on influenza virus particles but want them to be super-squeaky clean? Or perhaps you'd like to work with filamentous influenza virions but don't know how? Jack Hirst has the protocol chapter for you: link.springer.com/protocol/10....
link.springer.com
Purification of Influenza Virions
This chapter describes basic workflows for concentrating and for purifying influenza virions. It presents several ways in which ultracentrifugation can be used to concentrate influenza virions from th...
2111
Reposted by C.A.M(Xander)_de_Haan.bsky.social
Björn Meyer @bmeyer.bsky.social · 14/02/2025
Clear statement from the virology community
0117
Reposted by C.A.M(Xander)_de_Haan.bsky.social
Thelonevirologist @thelonevirologist.bsky.social · 14/02/2025
Deglycosylation and truncation in the neuraminidase stalk are functionally equivalent in enhancing the pathogenicity of a high pathogenicity avian influenza virus in chickens journals.asm.org/doi/10.1128/...
journals.asm.org
Deglycosylation and truncation in the neuraminidase stalk are functionally equivalent in enhancing the pathogenicity of a high pathogenicity avian influenza virus in chickens | Journal of Virology
Avian influenza poses significant economic challenges to the poultry industry and presents potential risks to human health. Understanding the molecular mechanisms that facilitate the emergence of chic...
011
Reposted by C.A.M(Xander)_de_Haan.bsky.social
Joost Snijder @joostsnijder.bsky.social · 07/02/2025
Structurally convergent antibodies derived from different vaccine strategies target the influenza virus HA anchor epitope with a subset of VH3 and VK3 genes www.nature.com/articles/s41...
nature.com
Structurally convergent antibodies derived from different vaccine strategies target the influenza virus HA anchor epitope with a subset of VH3 and VK3 genes - Nature Communications
Structurally convergent antibodies targeting the conserved influenza HA anchor epitope have provided a template for next-generation vaccine development. The authors identified four anchor antibodies e...
042
Reposted by C.A.M(Xander)_de_Haan.bsky.social
Veesler lab @veeslerlab.bsky.social · 07/02/2025
With participation of Jimin Lee, Jack Brown, Risako Gen, @dabiophysicist.bsky.social, Cameron Stewart in our lab & in collaboration with the labs of Huan Yan and Tyler Starr www.cell.com/cell/fulltex...
cell.com
Multiple independent acquisitions of ACE2 usage in MERS-related coronaviruses
Two coronaviruses related to MERS-CoV, which infect European Pipistrellus bats, have been found to use ACE2 as their receptor. These viruses target an ACE2 surface region distant from those recognized...
1139
C.A.M(Xander)_de_Haan.bsky.social @xdh.bsky.social · 30/01/2025
www.linkedin.com/posts/xueshe...
linkedin.com
Xuesheng WU on LinkedIn: After four incredible years, I have officially earned my PhD! Grateful for…
After four incredible years, I have officially earned my PhD! Grateful for all the support and for the many small but shining moments that made this journey…
010
C.A.M(Xander)_de_Haan.bsky.social @xdh.bsky.social · 28/01/2025
Since the emergence of clade 2.3.4.4 H5 viruses, they have shown a remarkable ability to team up with other NA subtypes (and with N1 without a stalk deletion). This in contrast to the “old” H5. Presumably linked to changes in receptor binding. After N2, N6, and N8, we now find N9.
000
Reposted by C.A.M(Xander)_de_Haan.bsky.social
Angie Rasmussen @angierasmussen.bsky.social · 27/01/2025
This is bad news. It suggests reassortment of circulating H5N1 viruses with viruses containing N9 NA. Although this indicates reassortment with avian viruses, it's still bad. Reassortment makes pandemics. The last 3/4 flu pandemics (and likely 1918 too) were reassortant viruses.
6320169
C.A.M(Xander)_de_Haan.bsky.social @xdh.bsky.social · 28/01/2025
www.nature.com/articles/s41...
nature.com
Receptor-binding proteins from animal viruses are broadly compatible with human cell entry factors - Nature Microbiology
Functional systematic pseudotype virus-based analysis of the ability of diverse animal viruses to enter into a panel of well-characterized human cell lines shows a broad compatibility between animal v...
010
Reposted by C.A.M(Xander)_de_Haan.bsky.social
Thijs Kuiken @thijskuiken.bsky.social · 27/01/2025
In recente dagen is weer een toename gezien in het aantal zieke en dode wilde vogels, vooral brandganzen, door hoog-pathogene vogelgriep. Het melden van dode vogels kan o.a. via de websites van het DWHC (dwhc.nl/meldingsform...) en Sovon (portal.sovon.nl/dood). www.sovon.nl/actueel/nieu...
Brandgans met oriëntatieproblemen, een symptoom van hoogpathogene vogelgriep. Foto: Roy Slaterus
0812
Reposted by C.A.M(Xander)_de_Haan.bsky.social
Utrecht Virology Lab @utrechtvirology.bsky.social · 27/01/2025
Today we gathered over coffee and cake to thank Raoul de Groot for 40 years of service to the Utrecht Virology Lab 💐 Raoul is, quite literally, a giant in the coronavirus field, and we are extremely fortunate to work with him! 😄
0283
Reposted by C.A.M(Xander)_de_Haan.bsky.social
Thelonevirologist @thelonevirologist.bsky.social · 24/01/2025
Association of poultry vaccination with interspecies transmission and molecular evolution of H5 subtype avian influenza virus www.science.org/doi/10.1126/...
science.org
Association of poultry vaccination with interspecies transmission and molecular evolution of H5 subtype avian influenza virus
Mass poultry vaccination affects H5 avian influenza virus transmission and evolution, revealing complex host-virus dynamics.
022
Reposted by C.A.M(Xander)_de_Haan.bsky.social
Michael Osterholm, PhD, MPH @mtosterholm.bsky.social · 24/01/2025
This is a brand new type of H5N1 virus activity. My description of over 40 million migratory waterfowl and their poop blowing in the wind with H5N1 virus attached isn't appealing but it is exactly what is happening and we're going to see more human cases related to that.
918980
C.A.M(Xander)_de_Haan.bsky.social @xdh.bsky.social · 24/01/2025
www.nature.com/articles/d41...
nature.com
‘Never seen anything like this’: Trump’s team halts NIH meetings and travel
In an unprecedented move, research-grant reviews have been suspended indefinitely at the world’s largest public funder of biomedical research.
010
C.A.M(Xander)_de_Haan.bsky.social @xdh.bsky.social · 23/01/2025
www.biorxiv.org/content/10.1...
biorxiv.org
Mapping the complete influenza A virus infection cycle through single vRNP imaging
Cell-to-cell heterogeneity is a common feature of viral infection that can generate enormous complexity, complicating understanding of infection progression and interpretation of differences between v...
000
C.A.M(Xander)_de_Haan.bsky.social @xdh.bsky.social · 15/01/2025
www.linkedin.com/posts/maria-...
linkedin.com
Maria Montoya on LinkedIn: Enyjoyin EPICVIR meetin in London. It was a great meeting with very…
Enyjoyin EPICVIR meetin in London. It was a great meeting with very interesting results coming together for the protect. Thanks everyone!
000
Reposted by C.A.M(Xander)_de_Haan.bsky.social
Thelonevirologist @thelonevirologist.bsky.social · 14/01/2025
H5N1 confirmed in more cats as probe into raw pet food widens www.cidrap.umn.edu/avian-influe...
cidrap.umn.edu
H5N1 confirmed in more cats as probe into raw pet food widens
042
Reposted by C.A.M(Xander)_de_Haan.bsky.social
Thelonevirologist @thelonevirologist.bsky.social · 13/01/2025
SLC35A2 modulates paramyxovirus fusion events during infection journals.plos.org/plospathogen...
journals.plos.org
SLC35A2 modulates paramyxovirus fusion events during infection
Author summary Paramyxovirus entry, the first step in establishing an infection, involves two key processes: attachment and virus-cell fusion. Paramyxoviruses use their attachment protein to bind to s...
074
Reposted by C.A.M(Xander)_de_Haan.bsky.social
Debby van Riel @debbyvanriel.bsky.social · 13/01/2025
Early career scientist in the field of respiratory virus infections: Check out these awards 👇🏼 Submit your application and join us at the ESWI conference in October in Valencia. Feel free to share 😀
22614
Reposted by C.A.M(Xander)_de_Haan.bsky.social
Thelonevirologist @thelonevirologist.bsky.social · 10/01/2025
Infection-induced lysine lactylation enables herpesvirus immune evasion www.science.org/doi/10.1126/...
science.org
Infection-induced lysine lactylation enables herpesvirus immune evasion
Virus induction of a Warburg-like effect promotes lactylation of immune response proteins to prevent initiation of host immunity.
022
Reposted by C.A.M(Xander)_de_Haan.bsky.social
Helen Branswell 🇨🇦 @helenbranswell.bsky.social · 10/01/2025
#USDA confirmed 1 more California dairy herd infected with #H5N1 #birdflu, bringing the state's total to 707 and the national total to 924 herds in 16 states. 72% of California's dairy herds have been infected. www.aphis.usda.gov/livestock-po...
17221
C.A.M(Xander)_de_Haan.bsky.social @xdh.bsky.social · 24/12/2024
www.uu.nl/en/organisat...
uu.nl
Postdoctoral Researcher in Structural Virology
This project is focused on deciphering the role of virally encoded AAA+ ATPases in the replication cycles of Enteroviruses and Noroviruses.
002
C.A.M(Xander)_de_Haan.bsky.social @xdh.bsky.social · 13/12/2024
www.uu.nl/en/news/new-...
uu.nl
New vaccine against deadly herpes virus in elephants tested in practice
The Faculty of Veterinary Medicine, in collaboration Rotterdam Zoo have started testing a vaccine to protect young elephants from the deadly elephant endotheliotropic herpesvirus (EEHV).
010
Reposted by C.A.M(Xander)_de_Haan.bsky.social
Infectious Disease Tracker @hmpxvt.bsky.social · 02/12/2024
According to CDC's wastewater program, almost all wastewater sample sites in California, from San Diego in the south to Redding in the north, have tested positive for H5 bird flu.
11304143
Reposted by C.A.M(Xander)_de_Haan.bsky.social
Debby van Riel @debbyvanriel.bsky.social · 02/12/2024
1/ Our recent publication is online. We show that a clade 2.3.4.4b H5N1 virus attaches to, and replicates more efficiently in human respiratory epithelium than a clade 2.3.2.1 H5N1 virus that circulated in 2005. www.biorxiv.org/content/10.1...
biorxiv.org
A 2022 avian H5N1 influenza A virus from clade 2.3.4.4b attaches to and replicates better in human respiratory epithelium than a 2005 H5N1 virus from clade 2.3.2.1
Background Highly pathogenic avian influenza (HPAI) H5 viruses of the A/Goose/Guangdong/1/1996 (GsGd) lineage pose significant global risks to wildlife, domestic animals, and humans. Recent cross-spec...
22411
C.A.M(Xander)_de_Haan.bsky.social @xdh.bsky.social · 01/12/2024
Had a great time with several former Chinese colleagues and Berend Jan Bosch in Nanjing. Thanks Wentao for the invitation!
011